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Michael A. Jakupec

Michael A. Jakupec

D-Index & Metrics

Chemistry

D-Index
77
Citations
19482
World Ranking
4068
National Ranking
17

Overview

Michael A. Jakupec is affiliated with the University of Vienna in Austria. Their research primarily spans the field of Materials Science, with a focus on Materials Chemistry. Additional areas of study include Oncology, Organic Chemistry, Molecular Biology, and Biomaterials.

The scientist's recent publications include the following works:

  • Microplastics role in cell migration and distribution during cancer cell division, 2024, Chemosphere
  • Plecstatin-1 induces an immunogenic cell death signature in colorectal tumour spheroids, 2020, Metallomics
  • Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)SbIII}4(A-α-XW9O34)2]n (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity, 2020, Inorganic Chemistry
  • Thermodynamic Genome-Scale Metabolic Modeling of Metallodrug Resistance in Colorectal Cancer, 2021, Cancers
  • Morpho-metabotyping the oxidative stress response, 2021, Scientific Reports

Frequent coauthors in their work include:

  • Bernhard K. Keppler
  • Michaela Hejl
  • Wolfgang Kandioller
  • Natalie Gajic
  • Sophia Harringer

Michael A. Jakupec has published extensively in several key venues, notably:

  • The Cambridge Structural Database (69 publications)
  • Dalton Transactions (6 publications)
  • Pharmaceutics (5 publications)
  • Inorganic Chemistry (3 publications)
  • JBIC Journal of Biological Inorganic Chemistry (2 publications)

Their research covers a variety of main topics including:

  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Metal complexes synthesis and properties
  • Ferrocene Chemistry and Applications
  • Lanthanide and Transition Metal Complexes
  • Synthesis and biological activity
  • Nanoparticle-Based Drug Delivery

Best Publications

  • From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)

    Christian G. Hartinger;Stefanie Zorbas-Seifried;Michael A. Jakupec;Bernd Kynast

  • KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients.

    Christian G. Hartinger;Christian G. Hartinger;Michael A. Jakupec;Stefanie Zorbas‐Seifried;Michael Groessl

  • Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches.

    Markus Galanski;Michael A. Jakupec;Bernhard K. Keppler

  • NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

    Robert Trondl;Petra Heffeter;Christian R. Kowol;Michael A. Jakupec

  • Antitumour metal compounds: more than theme and variations.

    Michael A. Jakupec;Markus Galanski;Vladimir B. Arion;Christian G. Hartinger

  • Recent Developments in the Field of Tumor-Inhibiting Metal Complexes

    M. Galanski;V. B. Arion;M. A. Jakupec;B. K. Keppler

  • Tumour-inhibiting platinum complexes--state of the art and future perspectives.

    M. A. Jakupec;M. Galanski;B. K. Keppler

  • Resistance against novel anticancer metal compounds: differences and similarities

    Petra Heffeter;Ute Jungwirth;Michael Jakupec;Christian Hartinger

  • Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells

    S. Kapitza;M. Pongratz;M. A. Jakupec;P. Heffeter

  • Transferrin binding and transferrin-mediated cellular uptake of the ruthenium coordination compound KP1019, studied by means of AAS, ESI-MS and CD spectroscopy

    Martina Pongratz;Petra Schluga;Michael A. Jakupec;Vladimir B. Arion

  • Pharmacological properties of cerium compunds

    M. A. Jakupec;P. Unfried;B. K. Keppler

  • Redox behavior of tumor-inhibiting ruthenium(III) complexes and effects of physiological reductants on their binding to GMP

    Petra Schluga;Christian G. Hartinger;Alexander Egger;Erwin Reisner

  • Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation

    Christian R. Kowol;Robert Trondl;Petra Heffeter;Vladimir B. Arion

  • Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): aquation, redox properties, protein binding, and antiproliferative activity.

    Michael Groessl;Erwin Reisner;Christian G. Hartinger;Rene Eichinger

  • Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity.

    Maria G. Mendoza-Ferri;Christian G. Hartinger;Marco A. Mendoza;Michael Groessl

  • Influence of the Spacer Length on the in Vitro Anticancer Activity of Dinuclear Ruthenium−Arene Compounds

    Maria-Grazia Mendoza-Ferri;Christian G. Hartinger;Rene E. Eichinger;Natalya Stolyarova

  • Redox-Active Antineoplastic Ruthenium Complexes with Indazole: Correlation of in Vitro Potency and Reduction Potential

    Michael A. Jakupec;Erwin Reisner;Anna Eichinger;Martina Pongratz

  • Gallium(III) and Iron(III) Complexes of α-N-Heterocyclic Thiosemicarbazones: Synthesis, Characterization, Cytotoxicity, and Interaction with Ribonucleotide Reductase

    Christian R. Kowol;Roland Berger;Rene Eichinger;Alexander Roller

  • Highly Antiproliferative Ruthenium(II) and Osmium(II) Arene Complexes with Paullone-Derived Ligands

    Wolfgang F. Schmid;Roland O. John;Vladimir B. Arion;Michael A. Jakupec

  • Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24).

    Petra Heffeter;Michael A. Jakupec;Wilfried Körner;Stefan Wild

Frequent Co-Authors

Bernhard K. Keppler
Bernhard K. Keppler University of Vienna
Christian G. Hartinger
Christian G. Hartinger University of Auckland
Vladimir B. Arion
Vladimir B. Arion University of Vienna
Walter Berger
Walter Berger Medical University of Vienna
Paul J. Dyson
Paul J. Dyson École Polytechnique Fédérale de Lausanne
Gunda Koellensperger
Gunda Koellensperger University of Vienna
Vadim Yu. Kukushkin
Vadim Yu. Kukushkin Saint Petersburg State University
Erwin Reisner
Erwin Reisner University of Cambridge
Michael Wagner
Michael Wagner University of Vienna
Gerhard Wiche
Gerhard Wiche Max F. Perutz Laboratories

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