D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 82 Citations 19,476 295 World Ranking 1831 National Ranking 143

Overview

What is she best known for?

The fields of study she is best known for:

  • Enzyme
  • Gene
  • Biochemistry

Her main research concerns Biochemistry, Stereochemistry, Carbonic anhydrase, Enzyme and In vitro. The various areas that Angela Casini examines in her Biochemistry study include Cell culture and Pharmacology. Her Stereochemistry research incorporates themes from Mechanism of action, Ruthenium, Ligand, DNA and Cytotoxicity.

Her Carbonic anhydrase study integrates concerns from other disciplines, such as Amino acid, Isozyme, Enzyme inhibitor and Active site. Her biological study spans a wide range of topics, including Extracellular, Transport protein, Hypoxia and Detoxification. Her work carried out in the field of In vitro brings together such families of science as Cell cycle checkpoint and Xanthine.

Her most cited work include:

  • Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. (554 citations)
  • Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs (391 citations)
  • Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition (356 citations)

What are the main themes of her work throughout her whole career to date?

Her primary areas of study are Stereochemistry, Biochemistry, Carbonic anhydrase, Combinatorial chemistry and In vitro. She interconnects Ruthenium, Ligand, Adduct, Reactivity and Thioredoxin reductase in the investigation of issues within Stereochemistry. Her work in Biochemistry addresses subjects such as Cisplatin, which are connected to disciplines such as Ex vivo, Platinum and DNA.

Her Carbonic anhydrase research focuses on subjects like Enzyme inhibitor, which are linked to Methazolamide and Biological activity. The Combinatorial chemistry study combines topics in areas such as Organic chemistry, Metal and Palladium. Her work investigates the relationship between In vitro and topics such as Pharmacology that intersect with problems in Toxicity.

She most often published in these fields:

  • Stereochemistry (50.87%)
  • Biochemistry (22.97%)
  • Carbonic anhydrase (13.95%)

What were the highlights of her more recent work (between 2015-2021)?

  • Stereochemistry (50.87%)
  • Combinatorial chemistry (15.99%)
  • In vitro (14.53%)

In recent papers she was focusing on the following fields of study:

Her primary areas of investigation include Stereochemistry, Combinatorial chemistry, In vitro, Gold Compounds and Cancer cell. Her Stereochemistry research integrates issues from Ligand, Metal, Carbene, Cytotoxicity and Thioredoxin reductase. Angela Casini has researched Combinatorial chemistry in several fields, including Group 2 organometallic chemistry, Palladium, Nuclear magnetic resonance spectroscopy, Mass spectrometry and Aqueous solution.

Her In vitro research is multidisciplinary, relying on both Cancer research, In vivo and Ligand. Her research integrates issues of Cell culture, Cisplatin, Bioconjugation, Biochemistry and Toxicity in her study of Cancer cell. When carried out as part of a general Biochemistry research project, her work on Permeation and Glycerol is frequently linked to work in Tartrate-resistant acid phosphatase, therefore connecting diverse disciplines of study.

Between 2015 and 2021, her most popular works were:

  • The Promise of Self-Assembled 3D Supramolecular Coordination Complexes for Biomedical Applications (72 citations)
  • Evaluation of new palladium cages as potential delivery systems for the anticancer drug cisplatin (64 citations)
  • Evaluation of new palladium cages as potential delivery systems for the anticancer drug cisplatin (64 citations)

In her most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Organic chemistry

Stereochemistry, Carbene, G-quadruplex, DNA and Combinatorial chemistry are her primary areas of study. In the field of Stereochemistry, her study on Moiety overlaps with subjects such as Gold Compounds. Her research in Moiety intersects with topics in Cell culture, Ex vivo, Cancer cell, Ligand and Cytotoxicity.

Her Carbene research is multidisciplinary, incorporating elements of Thioredoxin reductase and In vitro, Chorioallantoic membrane. Her G-quadruplex study combines topics in areas such as Selectivity and Electrospray ionization. Her study in Combinatorial chemistry is interdisciplinary in nature, drawing from both Coordination complex, Metal, Nuclear magnetic resonance spectroscopy and Group 2 organometallic chemistry.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

Eliška Švastová;Alžbeta Hulı́ková;Monika Rafajová;Miriam Zat'ovičová.
FEBS Letters (2004)

757 Citations

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

Alberto Bindoli;Maria Pia Rigobello;Guido Scutari;Chiara Gabbiani.
Coordination Chemistry Reviews (2009)

585 Citations

Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition

Alexander Weber;Angela Casini;Andreas Heine;Daniel Kuhn.
Journal of Medicinal Chemistry (2004)

517 Citations

Gold compounds as anticancer agents: Chemistry, cellular pharmacology, and preclinical studies

Stefania Nobili;Enrico Mini;Ida Landini;Chiara Gabbiani.
Medicinal Research Reviews (2010)

506 Citations

Protease inhibitors of the sulfonamide type: Anticancer, antiinflammatory, and antiviral agents

Claudiu T. Supuran;Angela Casini;Andrea Scozzafava.
Medicinal Research Reviews (2003)

493 Citations

A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds

Benoît Bertrand;Angela Casini.
Dalton Transactions (2014)

384 Citations

Organometallic ruthenium-based antitumor compounds with novel modes of action

Wee Han Ang;Angela Casini;Gianni Sava;Paul J. Dyson.
Journal of Organometallic Chemistry (2011)

384 Citations

Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX

Francesco Abbate;Angela Casini;Takashi Owa;Andrea Scozzafava.
Bioorganic & Medicinal Chemistry Letters (2004)

320 Citations

Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds

Angela Casini;Chiara Gabbiani;Francesca Sorrentino;Maria Pia Rigobello.
Journal of Medicinal Chemistry (2008)

317 Citations

Sulfonamides and sulfonylated derivatives as anticancer agents.

Angela casini;Andrea Scozzafava;Antonio Mastrolorenzo;Claudiu T. Supuran.
Current Cancer Drug Targets (2002)

308 Citations

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