Her main research concerns Biochemistry, Stereochemistry, Carbonic anhydrase, Enzyme and In vitro. The various areas that Angela Casini examines in her Biochemistry study include Cell culture and Pharmacology. Her Stereochemistry research incorporates themes from Mechanism of action, Ruthenium, Ligand, DNA and Cytotoxicity.
Her Carbonic anhydrase study integrates concerns from other disciplines, such as Amino acid, Isozyme, Enzyme inhibitor and Active site. Her biological study spans a wide range of topics, including Extracellular, Transport protein, Hypoxia and Detoxification. Her work carried out in the field of In vitro brings together such families of science as Cell cycle checkpoint and Xanthine.
Her primary areas of study are Stereochemistry, Biochemistry, Carbonic anhydrase, Combinatorial chemistry and In vitro. She interconnects Ruthenium, Ligand, Adduct, Reactivity and Thioredoxin reductase in the investigation of issues within Stereochemistry. Her work in Biochemistry addresses subjects such as Cisplatin, which are connected to disciplines such as Ex vivo, Platinum and DNA.
Her Carbonic anhydrase research focuses on subjects like Enzyme inhibitor, which are linked to Methazolamide and Biological activity. The Combinatorial chemistry study combines topics in areas such as Organic chemistry, Metal and Palladium. Her work investigates the relationship between In vitro and topics such as Pharmacology that intersect with problems in Toxicity.
Her primary areas of investigation include Stereochemistry, Combinatorial chemistry, In vitro, Gold Compounds and Cancer cell. Her Stereochemistry research integrates issues from Ligand, Metal, Carbene, Cytotoxicity and Thioredoxin reductase. Angela Casini has researched Combinatorial chemistry in several fields, including Group 2 organometallic chemistry, Palladium, Nuclear magnetic resonance spectroscopy, Mass spectrometry and Aqueous solution.
Her In vitro research is multidisciplinary, relying on both Cancer research, In vivo and Ligand. Her research integrates issues of Cell culture, Cisplatin, Bioconjugation, Biochemistry and Toxicity in her study of Cancer cell. When carried out as part of a general Biochemistry research project, her work on Permeation and Glycerol is frequently linked to work in Tartrate-resistant acid phosphatase, therefore connecting diverse disciplines of study.
Stereochemistry, Carbene, G-quadruplex, DNA and Combinatorial chemistry are her primary areas of study. In the field of Stereochemistry, her study on Moiety overlaps with subjects such as Gold Compounds. Her research in Moiety intersects with topics in Cell culture, Ex vivo, Cancer cell, Ligand and Cytotoxicity.
Her Carbene research is multidisciplinary, incorporating elements of Thioredoxin reductase and In vitro, Chorioallantoic membrane. Her G-quadruplex study combines topics in areas such as Selectivity and Electrospray ionization. Her study in Combinatorial chemistry is interdisciplinary in nature, drawing from both Coordination complex, Metal, Nuclear magnetic resonance spectroscopy and Group 2 organometallic chemistry.
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Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.
Eliška Švastová;Alžbeta Hulı́ková;Monika Rafajová;Miriam Zat'ovičová.
FEBS Letters (2004)
Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs
Alberto Bindoli;Maria Pia Rigobello;Guido Scutari;Chiara Gabbiani.
Coordination Chemistry Reviews (2009)
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition
Alexander Weber;Angela Casini;Andreas Heine;Daniel Kuhn.
Journal of Medicinal Chemistry (2004)
Gold compounds as anticancer agents: Chemistry, cellular pharmacology, and preclinical studies
Stefania Nobili;Enrico Mini;Ida Landini;Chiara Gabbiani.
Medicinal Research Reviews (2010)
Protease inhibitors of the sulfonamide type: Anticancer, antiinflammatory, and antiviral agents
Claudiu T. Supuran;Angela Casini;Andrea Scozzafava.
Medicinal Research Reviews (2003)
A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds
Benoît Bertrand;Angela Casini.
Dalton Transactions (2014)
Organometallic ruthenium-based antitumor compounds with novel modes of action
Wee Han Ang;Angela Casini;Gianni Sava;Paul J. Dyson.
Journal of Organometallic Chemistry (2011)
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX
Francesco Abbate;Angela Casini;Takashi Owa;Andrea Scozzafava.
Bioorganic & Medicinal Chemistry Letters (2004)
Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds
Angela Casini;Chiara Gabbiani;Francesca Sorrentino;Maria Pia Rigobello.
Journal of Medicinal Chemistry (2008)
Sulfonamides and sulfonylated derivatives as anticancer agents.
Angela casini;Andrea Scozzafava;Antonio Mastrolorenzo;Claudiu T. Supuran.
Current Cancer Drug Targets (2002)
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