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Chemistry
Italy
2025

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Chemistry

D-Index
77
Citations
20998
World Ranking
4018
National Ranking
76

Research.com Recognitions

  • 2025 - Research.com Chemistry in Italy Leader Award
  • 2022 - Research.com Chemistry in Italy Leader Award

Overview

Daniela Vullo is a researcher affiliated with the University of Florence in Italy. Their work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Chemistry, with notable contributions in subfields such as Molecular Biology, Organic Chemistry, Materials Chemistry, Pharmacology, and Physical and Theoretical Chemistry.

The core focus of their research revolves around enzyme function and inhibition, synthesis and catalytic reactions, as well as neurodegenerative diseases linked to cholinesterase activity. Additional topics include crystallization and solubility studies, X-ray diffraction in crystallography, and the synthesis and activities of phenothiazines and benzothiazines, alongside investigations into chemical reactions and mechanisms.

Recent publications by Daniela Vullo include:

  • "Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold" (2021) published in the European Journal of Medicinal Chemistry
  • "First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors" (2022) in the Journal of Enzyme Inhibition and Medicinal Chemistry
  • "One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes" (2021) in the Journal of Medicinal Chemistry
  • "New β-arylchalcogeno amines with procognitive properties targeting Carbonic Anhydrases and Monoamine Oxidases" (2022) published in the European Journal of Medicinal Chemistry
  • "Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors" (2023) in ACS Medicinal Chemistry Letters

Frequent publication venues for their work include:

  • The Cambridge Structural Database
  • Journal of Enzyme Inhibition and Medicinal Chemistry
  • European Journal of Medicinal Chemistry
  • Pharmaceuticals
  • Drug Development Research

Collaborations play a significant role in their research activities. Frequent co-authors include Claudiu T. Supuran, Dmitry Dar'in, Vasilisa Krivovicheva, Andrey Bubyrev, and Stanislav Kalinin.

Best Publications

  • Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

    Fabio Pacchiano;Fabrizio Carta;Paul C. McDonald;Yuanmei Lou

  • Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum—The η-carbonic anhydrases

    Sonia Del Prete;Daniela Vullo;Gillian Marie Fisher;Katherine Thea Andrews

  • CARBONIC ANHYDRASE IN THE SCLERACTINIAN CORAL STYLOPHORA PISTILLATA: CHARACTERIZATION, LOCALIZATION, AND ROLE IN BIOMINERALIZATION

    Aurélie Moya;Sylvie Tambutté;Anthony Bertucci;Eric Tambutté

  • Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?

    Daniela Vullo;Alessio Innocenti;Isao Nishimori;Jaromı́r Pastorek

  • Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.

    Daniela Vullo;Marco Franchi;Enzo Gallori;Jaromir Pastorek

  • Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.

    Brendan Luke Wilkinson;Laurent Bornaghi;Todd Ashley Houston;Alessio Innocenti

  • Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.

    Isao Nishimori;Tomoko Minakuchi;Kaori Morimoto;Shuichi Sano

  • Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.

    Kaspars Tars;Daniela Vullo;Andris Kazaks;Janis Leitans

  • Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).

    Alessio Innocenti;Daniela Vullo;Andrea Scozzafava;Claudiu T. Supuran

  • Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.

    Silvia Pastorekova;Angela Casini;Andrea Scozzafava;Daniela Vullo

  • Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase Can2 from the Pathogenic Fungus Cryptococcus neoformans

    Christine Schlicker;Rebecca A. Hall;Daniela Vullo;Sabine Middelhaufe

  • Carbonic Anhydrase Inhibitors. The Mitochondrial Isozyme VB as a New Target for Sulfonamide and Sulfamate Inhibitors

    Isao Nishimori;Daniela Vullo;Alessio Innocenti;Andrea Scozzafava

  • A spectroscopic study of the reaction of NAMI, a novel ruthenium(III)anti-neoplastic complex, with bovine serum albumin.

    Luigi Messori;Pierluigi Orioli;Daniela Vullo;Enzo Alessio

  • Designing of Novel Carbonic Anhydrase Inhibitors and Activators.

    Claudiu T Supuran;Daniela Vullo;Gheorghe Manole;Angela Casini

  • Carbonic anhydrase inhibitors: The β-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors

    Isao Nishimori;Tomoko Minakuchi;Takuhiro Kohsaki;Saburo Onishi

  • Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

    Vladimir Garaj;Luca Puccetti;Giuseppe Fasolis;Jean-Yves Winum;Jean-Yves Winum

  • Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.

    ‡ Jean-Yves Winum;Claudia Temperini;Khaled El Cheikh;Alessio Innocenti

  • Carbonic Anhydrase Inhibitors. Design of Selective, Membrane-Impermeant Inhibitors Targeting the Human Tumor-Associated Isozyme IX

    Joseph. R. Casey;Patricio E. Morgan;Daniela Vullo;Andrea Scozzafava

  • Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff’s bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes

    Luca Puccetti;Giuseppe Fasolis;Daniela Vullo;Zahid H. Chohan

  • Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.

    Marc A Ilies;Daniela Vullo;Jaromir Pastorek;Andrea Scozzafava

Frequent Co-Authors

Claudiu T. Supuran
Claudiu T. Supuran University of Florence
Andrea Scozzafava
Andrea Scozzafava University of Florence
Clemente Capasso
Clemente Capasso National Academies of Sciences, Engineering, and Medicine
Alessio Innocenti
Alessio Innocenti University of Florence
Fabrizio Carta
Fabrizio Carta University of Florence
Jean-Yves Winum
Jean-Yves Winum University of Montpellier
Zeid A. ALOthman
Zeid A. ALOthman King Saud University
Sally-Ann Poulsen
Sally-Ann Poulsen Griffith University
Seppo Parkkila
Seppo Parkkila Tampere University
Silvia Pastorekova
Silvia Pastorekova Slovak Academy of Sciences

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