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Seppo Parkkila

Seppo Parkkila

D-Index & Metrics

Biology and Biochemistry

D-Index
87
Citations
24025
World Ranking
2871
National Ranking
19

Medicine

D-Index
87
Citations
24476
World Ranking
13761
National Ranking
157

Overview

Seppo Parkkila is affiliated with Tampere University in Finland and has a research focus primarily in the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their work spans multiple subfields including Molecular Biology, Organic Chemistry, Infectious Diseases, Pharmacology, and Public Health, Environmental and Occupational Health.

The researcher has contributed extensively to topics such as enzyme function and inhibition, synthesis and catalytic reactions, cholinesterase and neurodegenerative diseases, phenothiazines and benzothiazines synthesis and activities, computational drug discovery methods, research on leishmaniasis studies, and COVID-19 clinical research studies.

Parkkila has published in a variety of scientific venues, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Enzyme Inhibition and Medicinal Chemistry
  • Frontiers in Pharmacology
  • The "Enzymes"
  • International Reviews of Immunology

Recent notable papers include:

  • "Brucellosis: epidemiology, pathogenesis, diagnosis and treatment-a comprehensive review," 2023, Annals of Medicine
  • "Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology," 2022, Physiological Reviews
  • "SARS-CoV-2 variants and COVID-19 vaccines: Current challenges and future strategies," 2022, International Reviews of Immunology
  • "Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial," 2022, Nature Communications
  • "Tuberculosis vaccine BCG: the magical effect of the old vaccine in the fight against the COVID-19 pandemic," 2021, International Reviews of Immunology

Collaboration is a significant aspect of Parkkila's research, with frequent co-authors including Ashok Aspatwar, Claudiu T. Supuran, Harlan Barker, Ratul Bhowmik, and Andrea Angeli. These collaborators have contributed to many joint publications, reflecting active research networks.

Best Publications

  • Carbonic anhydrases: current state of the art, therapeutic applications and future prospects.

    Silvia Pastorekova;Seppo Parkkila;Jaromir Pastorek;Claudiu T Supuran

  • The Hemochromatosis Founder Mutation in HLA-H Disrupts β2-Microglobulin Interaction and Cell Surface Expression

    John N. Feder;Zenta Tsuchihashi;Alivelu Irrinki;Vincent K. Lee

  • HFE gene knockout produces mouse model of hereditary hemochromatosis

    Xiao Yan Zhou;Shunji Tomatsu;Robert E. Fleming;Seppo Parkkila

  • Experimental liver cirrhosis induced by alcohol and iron.

    Hidekazu Tsukamoto;Walter Horne;Seiichiro Kamimura;Onni Niemelä

  • Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

    Vincenzo Alterio;Mika Hilvo;Anna Di Fiore;Claudiu T. Supuran

  • Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with β2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells

    Abdul Waheed;Seppo Parkkila;Xiao Yan Zhou;Shunji Tomatsu

  • Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

    Seppo Parkkila;Abdul Waheed;Robert S. Britton;Bruce R. Bacon

  • Carbonic anhydrase IX, MN/CA IX : Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts

    S Pastorekova;S Parkkila;AK Parkkila;R Opavsky

  • Carbonic anhydrase IX in oligodendroglial brain tumors

    Sally Järvelä;Seppo Parkkila;Helena Bragge;Marketta Kähkönen

  • Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.

    Mika Hilvo;Lina Baranauskiene;Anna Maria Salzano;Andrea Scaloni

  • Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro.

    Seppo Parkkila;Hannu Rajaniemi;Anna-Kaisa Parkkila;Jyrki Kivelä

  • Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation

    Juha Saarnio;Seppo Parkkila;Anna-Kaisa Parkkila;Kari Haukipuro

  • Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract.

    Seppo Parkkila;Abdul Waheed;Robert S. Britton;John N. Feder

  • Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

    Abdul Waheed;Seppo Parkkila;Juha Saarnio;Robert E. Fleming

  • Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family

    Jonna Lehtonen;Bairong Shen;Mauno Vihinen;Angela Casini

  • Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig.

    Charles H. Halsted;Jesus A. Villanueva;Angela M. Devlin;Onni Niemelä

  • Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease

    Onni Nlemelä;Seppo Parkkila;Seppo Ylä‐herttuala;Jesus Villanueva

  • Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases.

    Onni Niemelä;Seppo Parkkila;Risto O Juvonen;Katja Viitala

  • Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase.

    Mika Hilvo;Martti Tolvanen;Amy Clark;Bairong Shen

  • Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with b2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells (degradationyGolgi processingyintracellular transportyironymajor histocompatibility complex class I protein)

    Abdul Waheed;Seppo Parkkila;Xiao Yan Zhou;Shunji Tomatsu

Frequent Co-Authors

Claudiu T. Supuran
Claudiu T. Supuran University of Florence
Anna-Kaisa Parkkila
Anna-Kaisa Parkkila University of Oulu
William S. Sly
William S. Sly Saint Louis University
Abdul Waheed
Abdul Waheed Saint Louis University
Hannu Rajaniemi
Hannu Rajaniemi University of Oulu
Silvia Pastorekova
Silvia Pastorekova Slovak Academy of Sciences
Jaromir Pastorek
Jaromir Pastorek Slovak Academy of Sciences
Andrea Scozzafava
Andrea Scozzafava University of Florence
Tuomo J. Karttunen
Tuomo J. Karttunen Oulu University Hospital
Bruce R. Bacon
Bruce R. Bacon Saint Louis University

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