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Alaa A.-M. Abdel-Aziz

Alaa A.-M. Abdel-Aziz

D-Index & Metrics

Chemistry

D-Index
43
Citations
5584
World Ranking
17342
National Ranking
84

Overview

Alaa A.-M. Abdel-Aziz is affiliated with King Saud University in Saudi Arabia and has contributed extensively to research in chemistry, medicine, and biochemistry, genetics, and molecular biology. Their work emphasizes organic chemistry and spans molecular biology, oncology, hematology, and materials chemistry.

The main research topics of their work include:

  • Synthesis and biological activity
  • Quinazolinone synthesis and applications
  • Cancer therapeutics and mechanisms
  • Synthesis and Biological Evaluation
  • Enzyme function and inhibition
  • Synthesis and Characterization of Heterocyclic Compounds
  • Synthesis and Catalytic Reactions

Recent notable papers authored with contribution from Alaa A.-M. Abdel-Aziz include:

  • Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects, 2020, Bioorganic Chemistry
  • Synergistic Anti Leukemia Effect of a Novel Hsp90 and a Pan Cyclin Dependent Kinase Inhibitors, 2020, Molecules
  • Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis, 2020, Bioorganic Chemistry
  • Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies, 2022, Bioorganic Chemistry
  • S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors, 2020, Journal of Enzyme Inhibition and Medicinal Chemistry

The researcher frequently collaborates with several coauthors, including:

  • Adel S. El-Azab
  • Mohamed Hefnawy
  • Hamad M. Alkahtani
  • Ahmed H. Bakheit
  • Nawaf A. Alsaif

Publications by Alaa A.-M. Abdel-Aziz often appear in these venues:

  • Journal of Enzyme Inhibition and Medicinal Chemistry
  • Bioorganic Chemistry
  • Molecules
  • Saudi Pharmaceutical Journal
  • RSC Advances

The research spans multiple disciplines and subfields, with a strong focus on organic chemistry for the design and synthesis of biologically active compounds. The work also covers cancer mechanisms, enzyme inhibition, and molecular evaluations of novel chemical scaffolds with potential therapeutic applications.

Best Publications

  • Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study

    Adel S. El-Azab;Mohamed A. Al-Omar;Alaa A.-M. Abdel-Aziz;Naglaa I. Abdel-Aziz

  • Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs.

    Sarah T. Al-Rashood;Ihsan A. Aboldahab;Mahmoud N. Nagi;Laila A. Abouzeid

  • Substituted quinazolines, part 3. Synthesis, in vitro antitumor activity and molecular modeling study of certain 2-thieno-4(3H)-quinazolinone analogs.

    Abdulrahman M. Al-Obaid;Sami G. Abdel-Hamide;Hassan A. El-Kashef;Alaa A.-M. Abdel-Aziz

  • Novel and versatile methodology for synthesis of cyclic imides and evaluation of their cytotoxic, DNA binding, apoptotic inducing activities and molecular modeling study

    Alaa A.-M. Abdel-Aziz

  • Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.

    Magda A.-A. El-Sayed;Naglaa I. Abdel-Aziz;Alaa A.-M. Abdel-Aziz;Alaa A.-M. Abdel-Aziz;Adel S. El-Azab;Adel S. El-Azab

  • Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.

    Magda A.-A. El-Sayed;Naglaa I. Abdel-Aziz;Alaa A.-M. Abdel-Aziz;Alaa A.-M. Abdel-Aziz;Adel S. El-Azab;Adel S. El-Azab

  • Non-classical antifolates. Part 2: Synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones

    Fatmah A.M. Al-Omary;Laila A. Abou-zeid;Mahmoud N. Nagi;El-Sayed E. Habib

  • Synthesis, antimicrobial activity and conformational analysis of novel substituted pyridines: BF3-promoted reaction of hydrazine with 2-alkoxy pyridines

    Fatma E. Goda;Alaa A.-M. Abdel-Aziz;Omer A. Attef

  • Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.

    Amer M. Alanazi;Adel S. El-Azab;Adel S. El-Azab;Ibrahim A. Al-Suwaidan;Kamal Eldin H. ElTahir

  • Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.

    Alaa A.-M. Abdel-Aziz;Kamal E.H. ElTahir;Yousif A. Asiri

  • Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones.

    Alaa A.-M. Abdel-Aziz;Alaa A.-M. Abdel-Aziz;Laila A. Abou-Zeid;Kamal Eldin H. ElTahir;Rezk R. Ayyad

  • Synthesis and antitumor evaluation of trimethoxyanilides based on 4(3H)-quinazolinone scaffolds.

    Menshawy A. Mohamed;Rezk R. Ayyad;Taghreed Z. Shawer;Alaa A.-M. Abdel-Aziz

  • Synthesis, antimicrobial activity and molecular modeling of cobalt and nickel complexes containing the bulky ligand: bis(N-(2,6-diisopropylphenyl)imino) acenaphthene

    Usama El-Ayaan;Alaa A.-M. Abdel-Aziz

  • Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies.

    Alaa A.-M. Abdel-Aziz;Alaa A.-M. Abdel-Aziz;Laila A. Abou-Zeid;Kamal Eldin H. ElTahir;Menshawy A. Mohamed;Menshawy A. Mohamed

  • Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: Dual cyclooxygenase/carbonic anhydrase inhibitory actions.

    Alaa A.-M. Abdel-Aziz;Alaa A.-M. Abdel-Aziz;Andrea Angeli;Adel S. El-Azab;Mohammed E.A. Hammouda

  • Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibition activities and molecular docking study of pyrazoline derivatives.

    Maged A. Abdel-Sayed;Said M. Bayomi;Magda A. El-Sherbeny;Naglaa I. Abdel-Aziz

  • Lewis acid-promoted transformation of 2-alkoxypyridines into 2-aminopyridines and their antibacterial activity. Part 2: Remarkably facile C-N bond formation.

    Alaa A.-M. Abdel-Aziz;Hussein I. El-Subbagh;Takehisa Kunieda

  • Design, synthesis and biological evaluation of some novel substituted quinazolines as antitumor agents.

    Amer M. Alanazi;Alaa A.-M. Abdel-Aziz;Ibrahim A. Al-Suwaidan;Sami G. Abdel-Hamide

  • Design, synthesis and antibacterial activity of fluoroquinolones containing bulky arenesulfonyl fragment: 2D-QSAR and docking study.

    Alaa A.-M. Abdel-Aziz;Yousif A. Asiri;Mohamed H.M. Al-Agamy

  • Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies.

    Alaa A.-M. Abdel-Aziz;Alaa A.-M. Abdel-Aziz;Adel S. El-Azab;Laila A. Abou-Zeid;Kamal Eldin H. ElTahir

  • Synthesis, Antiinflammatory Activity and COX-1/COX-2 Inhibition of Novel Substituted Cyclic Imides. Part 1. Molecular Docking Study.

    Alaa A.‐M. Abdel‐Aziz;Kamal E. H. ElTahir;Yousif A. Asiri

Frequent Co-Authors

Seik Weng Ng
Seik Weng Ng University of Malaya
Edward R. T. Tiekink
Edward R. T. Tiekink Sunway University
Claudiu T. Supuran
Claudiu T. Supuran University of Florence
Joel T. Mague
Joel T. Mague Tulane University
Y. Sheena Mary
Y. Sheena Mary Fatima Mata National College
Hoong-Kun Fun
Hoong-Kun Fun Universiti Sains Malaysia
C. Van Alsenoy
C. Van Alsenoy University of Antwerp
Nunziatina De Tommasi
Nunziatina De Tommasi University of Salerno
Deniz Ekinci
Deniz Ekinci Ondokuz Mayıs University
C. Yohannan Panicker
C. Yohannan Panicker TKM College of Engineering

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