Brian Schaffhausen

Overview

Best Publications

• SH2 domains recognize specific phosphopeptide sequences

  Songyang Zhou;Songyang Zhou;Steven E. Shoelson;Manas Chaudhuri;Gerald Gish

  3551
  Citations

• Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation.

  Malcolm Whitman;David R. Kaplan;Brian Schaffhausen;Lewis Cantley

  969
  Citations

• Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

  Margaret M. Chou;Weimin Hou;Joanne Johnson;Lauren K. Graham

  815
  Citations

• Purification and characterization of phosphoinositide 3-kinase from rat liver.

  C L Carpenter;B C Duckworth;K R Auger;B Cohen

  815
  Citations

• Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

  David R. Kaplan;Malcolm Whitman;Brian Schaffhausen;David C. Pallas

  783
  Citations

• IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

  Martin G. Myers;Jonathan M. Backer;Xiao Jian Sun;Steven Shoelson

  648
  Citations

• Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit.

  C. L. Carpenter;K. R. Auger;Manas Chanudhuri;M. Yoakim

  484
  Citations

• A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.

  C. L. Carpenter;K. R. Auger;B. C. Duckworth;Wei-Min Hou

  305
  Citations

• DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication.

  K S Campbell;K P Mullane;I A Aksoy;H Stubdal

  277
  Citations

• Phosphatidylinositol metabolism and polyoma-mediated transformation.

  David R. Kaplan;Malcolm Whitman;Brian Schaffhausen;Leda Raptis

  275
  Citations

• Conformational changes associated with f-1 histone-deoxyribonucleic acid complexes. Circular dichroism studies

  Gerald D. Fasman;B. Schaffhausen;L. Goldsmith;Alice J. Adler

  251
  Citations

• Phosphorylation of polyoma T antigens.

  B.S. Schaffhausen;T.L. Benjamin

  224
  Citations

• Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen

  Kathryn S. Campbell;Egon Ogris;Brenda Burke;Wen Su

  216
  Citations

• Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.

  Rosana Kapeller;Kanteti V S Prasad;Ottmar Janssen;Weimin Hou

  211
  Citations

• Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen

  Michele M. Fluck;Brian S. Schaffhausen

  208
  Citations

• Tumor antigen(s) in cells productively infected by wild-type polyoma virus and mutant NG-18

  Brian S. Schaffhausen;Jonathan E. Silver;Thomas L. Benjamin

  206
  Citations

• Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens

  Jingwei Cheng;James A. DeCaprio;Michele M. Fluck;Brian S. Schaffhausen

  205
  Citations

• Carboxy terminus of polyoma middle-sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation.

  Gordon G. Carmichael;Brian S. Schaffhausen;David I. Dorsky;Donald B. Oliver

  174
  Citations

• Tumor antigens induced by nontransforming mutants of polyoma virus.

  Jonathan Silver;Jonathan Silver;Brian Schaffhausen;Thomas Benjamin

  174
  Citations

• Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains

  Benchun Miao;Igor Skidan;Jinsheng Yang;Alexey Lugovskoy

  168
  Citations