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Biology and Biochemistry

D-Index
48
Citations
15364
World Ranking
18203
National Ranking
7438

Overview

Malcolm Whitman is affiliated with Harvard University in the United States, specializing in research at the intersection of medicine and biochemistry. Their work predominantly focuses on molecular biology, with additional involvement in hematology, immunology, genetics, and oncology.

Their research investigates several main topics including:

  • RNA and protein synthesis mechanisms
  • Platelet disorders and treatments
  • Blood properties and coagulation
  • Interferon and immune responses
  • Immune cell function and interaction
  • Pneumocystis jirovecii pneumonia detection and treatment
  • HIV/AIDS drug development and treatment

Among the recent publications authored or co-authored by Whitman, notable papers include:

  • "Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells," published in 2020 in the Proceedings of the National Academy of Sciences
  • "Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance," published in 2022 in Nature Communications
  • "The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation," published in 2021 in Blood
  • "Loss of Vlk in Prx1+ Cells Delays the Initial Steps of Endochondral Bone Formation and Fracture Repair in the Limb," published in 2020 in the Journal of Bone and Mineral Research
  • "GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling," published in 2025 in Science

Whitman frequently collaborates with several co-authors, including:

  • Leila Revollo
  • Andreia Ionescu
  • Tracy Keller
  • Glenn Merrill-Skoloff
  • Karen De Ceunynck

Their research is published in various scientific venues, with repeated contributions to:

  • Blood
  • Proceedings of the National Academy of Sciences
  • Nature Communications
  • Journal of Bone and Mineral Research
  • Science

Best Publications

  • Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.

    M Whitman;C P Downes;M Keeler;T Keller

  • Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation.

    Malcolm Whitman;David R. Kaplan;Brian Schaffhausen;Lewis Cantley

  • A transcriptional partner for MAD proteins in TGF-beta signalling.

    Xin Chen;Melissa J. Rubock;Malcolm Whitman

  • Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

    David R. Kaplan;Malcolm Whitman;Brian Schaffhausen;David C. Pallas

  • Smad4 and FAST-1 in the assembly of activin-responsive factor.

    Xin Chen;Ellen Weisberg;Valerie Fridmacher;Minoru Watanabe

  • Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures.

    G. Thomsen;T. Woolf;M. Whitman;S. Sokol

  • Smads and early developmental signaling by the TGFbeta superfamily.

    Malcolm Whitman

  • Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol

    Yoshikazu Sugimoto;Malcolm Whitman;Lewis C. Cantley;R. L. Erikson

  • Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response

    Mark S. Sundrud;Sergei B. Koralov;Markus Feuerer;Dinis Pedro Calado

  • Nodal Signals to Smads through Cripto-Dependent and Cripto-Independent Mechanisms

    Chang Yeol Yeo;Malcolm Whitman

  • Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

    Tracy L. Keller;Davide Zocco;Mark S. Sundrud;Margaret Hendrick

  • Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation.

    M Whitman;D Kaplan;T Roberts;L Cantley

  • Mesoderm induction by activin requires FGF-mediated intracellular signals

    C. Labonne;M. Whitman

  • Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning

    S. Paul Oh;Chang Yeol Yeo;Youngjae Lee;Heindrich Schrewe

  • Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development.

    S. Faure;M.A. Lee;T. Keller;P. ten Dijke

  • Nodal Signaling in Early Vertebrate Embryos: Themes and Variations

    Malcolm Whitman

  • Left–Right Asymmetric Expression of lefty2 and nodal Is Induced by a Signaling Pathway that Includes the Transcription Factor FAST2

    Yukio Saijoh;Hitoshi Adachi;Rui Sakuma;Chang Yeol Yeo

  • Phosphatidylinositol metabolism and polyoma-mediated transformation.

    David R. Kaplan;Malcolm Whitman;Brian Schaffhausen;Leda Raptis

  • Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2.

    Hidetaka Shiratori;Rui Sakuma;Minoru Watanabe;Hiromi Hashiguchi

  • Involvement of p21ras in Xenopus mesoderm induction.

    Malcolm Whitman;D. A. Melton

Frequent Co-Authors

Ralph Mazitschek
Ralph Mazitschek Harvard University
Lewis C. Cantley
Lewis C. Cantley Harvard University
Thomas M. Roberts
Thomas M. Roberts Harvard University
Brian Schaffhausen
Brian Schaffhausen Tufts University
Anjana Rao
Anjana Rao La Jolla Institute For Allergy & Immunology
Douglas A. Melton
Douglas A. Melton Harvard University
Vicki Rosen
Vicki Rosen Harvard University
Joseph E. Italiano
Joseph E. Italiano Boston Children's Hospital
Dyann F. Wirth
Dyann F. Wirth Harvard University
David L. Kaplan
David L. Kaplan Tufts University

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