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Biology and Biochemistry

D-Index
83
Citations
27322
World Ranking
3469
National Ranking
211

Overview

Hiroshi Hamada is affiliated with the RIKEN Center for Biosystems Dynamics Research in Japan. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions also in Medicine. They engage deeply in subfields including Molecular Biology, Genetics, Surgery, Cell Biology, and Public Health, Environmental and Occupational Health.

Their work covers a range of main topics such as Congenital heart defects research, Genetic and Kidney Cyst Diseases, Microtubule and mitosis dynamics, Protist diversity and phylogeny, Developmental Biology and Gene Regulation, Renal and related cancers, and Reproductive Biology and Fertility.

Hamada has published extensively, with some of the most recent papers including:

  • "Immotile cilia mechanically sense the direction of fluid flow for left-right determination" (2023) in Science
  • "CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module" (2020) in Nature Communications
  • "Molecular and cellular basis of left-right asymmetry in vertebrates" (2020) in Proceedings of the Japan Academy Series B
  • "Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex" (2021) in Nature Communications
  • "Diversity of left-right symmetry breaking strategy in animals" (2020) in F1000Research

The frequent coauthors collaborating with Hamada include:

  • Yayoi Ikawa
  • Katsura Minegishi
  • Takanobu A. Katoh
  • Hiromi Nishimura
  • Eriko Kajikawa

Hamada often publishes in venues such as Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, PLoS Genetics, and Developmental Biology.

Best Publications

  • Retinoid Signaling Determines Germ Cell Fate in Mice

    Josephine Bowles;Deon Knight;Christopher Smith;Dagmar Wilhelm

  • A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells

    Koji Okamoto;Hitoshi Okazawa;Akihiko Okuda;Masaharu Sakai

  • Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.

    Sadayo Nakajima-Iijima;Hiroshi Hamada;Premkumar Reddy;Takeo Kakunaga

  • A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes

    Hiroshi Hamada;Marianne G. Petrino;Takeo Kakunaga

  • Determination of left–right patterning of the mouse embryo by artificial nodal flow

    Shigenori Nonaka;Hidetaka Shiratori;Yukio Saijoh;Hiroshi Hamada

  • lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal

    Chikara Meno;Akihiko Shimono;Yukio Saijoh;Kenta Yashiro

  • Establishment of vertebrate left-right asymmetry

    Hiroshi Hamada;Chikara Meno;Daisuke Watanabe;Yukio Saijoh

  • An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation

    Owen W.J. Prall;Mary K. Menon;Mark J. Solloway;Yusuke Watanabe

  • Left–right asymmetric expression of the TGFβ-family member lefty in mouse embryos

    Chikara Meno;Yukio Saijoh;Yukio Saijoh;Hideta Fujii;Hideta Fujii;Masako Ikeda

  • Nodal Antagonists in the Anterior Visceral Endoderm Prevent the Formation of Multiple Primitive Streaks

    Aitana Perea-Gomez;Francis D.J. Vella;William Shawlot;Mustapha Oulad-Abdelghani

  • Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry

    Hidefumi Yoshioka;Chikara Meno;Kazuko Koshiba;Minoru Sugihara

  • The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo

    Yasuo Sakai;Chikara Meno;Hideta Fujii;Jinsuke Nishino

  • Abnormal Nodal Flow Precedes Situs Inversus in iv and inv mice

    Yasushi Okada;Shigenori Nonaka;Yosuke Tanaka;Yukio Saijoh

  • Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.

    Chikara Meno;Kira Gritsman;Sachiko Ohishi;Yasuhisa Ohfuji

  • Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos

    Hideta Fujii;Takashi Sato;Sinya Kaneko;Osamu Gotoh

  • Potential Z-DNA forming sequences are highly dispersed in the human genome

    Hiroshi Hamada;Takeo Kakunaga

  • Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells.

    Shinya Tanaka;Yusuke Kamachi;Aki Tanouchi;Hiroshi Hamada

  • Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

    Masamichi Yamamoto;Yukio Saijoh;Aitana Perea-Gomez;Aitana Perea-Gomez;William Shawlot;William Shawlot

  • The left-right axis in the mouse: from origin to morphology.

    Hidetaka Shiratori;Hiroshi Hamada

  • Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb.

    Kenta Yashiro;Xianling Zhao;Masayuki Uehara;Kimiyo Yamashita

Frequent Co-Authors

Yukio Saijoh
Yukio Saijoh University of Utah
Takuji Ishikawa
Takuji Ishikawa Tohoku University
Anthony Wynshaw-Boris
Anthony Wynshaw-Boris Case Western Reserve University
Michael M. Shen
Michael M. Shen Columbia University
Masami Muramatsu
Masami Muramatsu Saitama Medical University
Richard P. Harvey
Richard P. Harvey Victor Chang Cardiac Research Institute
Yumiko Saga
Yumiko Saga National Institute of Genetics
Janet Rossant
Janet Rossant University of Toronto
Sally L. Dunwoodie
Sally L. Dunwoodie Victor Chang Cardiac Research Institute
Nicholas Katsanis
Nicholas Katsanis Galatea Bio Inc

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