World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
15984
World Ranking
11797
National Ranking
5074

Research.com Recognitions

  • 1963 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

H. Joseph Yost is affiliated with the University of Utah in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research encompasses molecular biology, epidemiology, genetics, cardiology and cardiovascular medicine, as well as pulmonary and respiratory medicine. The scientist's work primarily addresses congenital heart disease studies, congenital heart defects research, CRISPR and genetic engineering, genomics and rare diseases, pluripotent stem cells research, machine learning in healthcare, and artificial intelligence in healthcare.

Yost's publication record includes recent papers such as:

  • MIC-Drop: A platform for large-scale in vivo CRISPR screens (2021, Science)
  • Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency (2021, Circulation Research)
  • An explainable artificial intelligence approach for predicting cardiovascular outcomes using electronic health records (2022, PLOS Digital Health)
  • Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects (2020, JACC Basic to Translational Science)
  • Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes (2025, Proceedings of the National Academy of Sciences)

Frequent co-authors in Yost's collaborative network include:

  • Martin Tristani-Firouzi (9 collaborative works)
  • Bruce D. Gelb (8 collaborative works)
  • Christine E. Seidman (8 collaborative works)
  • Wendy K. Chung (7 collaborative works)
  • Mark Yandell (6 collaborative works)

The scientist's work is often published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory) (6 publications)
  • Proceedings of the National Academy of Sciences (2 publications)
  • Developmental Dynamics (2 publications)
  • Science (1 publication)
  • PLOS Digital Health (1 publication)

Yost's research integrates advanced genetic and molecular biological methods, including CRISPR technology, to investigate congenital heart diseases and their genetic underpinnings. Their work also incorporates data-driven techniques such as explainable artificial intelligence applied to healthcare data, aiming to predict cardiovascular outcomes.

The scientist has been acknowledged as a Fellow of the American Association for the Advancement of Science (AAAS) since 1963.

Best Publications

  • The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs.

    Kristen M. Kwan;Esther Fujimoto;Clemens Grabher;Benjamin D. Mangum

  • Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands

    Sheng Chih Jin;Jason Homsy;Samir Zaidi;Qiongshi Lu

  • Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut.

    Jeffrey J. Essner;Jeffrey D. Amack;Molly K. Nyholm;Erin B. Harris

  • RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis

    H.Joseph Yost;Susan Lindquist

  • Siah-1 Mediates a Novel β-Catenin Degradation Pathway Linking p53 to the Adenomatous Polyposis Coli Protein

    Jun Liu;Jeffery Stevens;Cynthia A Rote;H.Joseph Yost

  • Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement

    Masaaki Yoshigi;Masaaki Yoshigi;Laura M. Hoffman;Laura M. Hoffman;Christopher C. Jensen;H. Joseph Yost;H. Joseph Yost

  • Conserved function for embryonic nodal cilia.

    Jeffrey J. Essner;Kyle J. Vogan;Molly K. Wagner;Clifford J. Tabin

  • The roles of cilia in developmental disorders and disease

    Brent W. Bisgrove;H. Joseph Yost

  • MMAPPR: Mutation Mapping Analysis Pipeline for Pooled RNA-seq

    Jonathon T. Hill;Bradley L. Demarest;Brent W. Bisgrove;Bushra Gorsi

  • Structure and function of the developing zebrafish heart.

    Norman Hu;David Sedmera;H. Joseph Yost;H. Joseph Yost;Edward B. Clark;Edward B. Clark

  • FGF signalling during embryo development regulates cilia length in diverse epithelia

    Judith M. Neugebauer;Jeffrey D. Amack;Jeffrey D. Amack;Annita G. Peterson;Brent W. Bisgrove

  • Cardiac morphology and blood pressure in the adult zebrafish.

    Norman Hu;H. Joseph Yost;H. Joseph Yost;Edward B. Clark;Edward B. Clark

  • Poly peak parser: Method and software for identification of unknown indels using sanger sequencing of polymerase chain reaction products

    Jonathon T. Hill;Bradley L. Demarest;Brent W. Bisgrove;Yi Chu Su

  • Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left–right axis

    Brent W. Bisgrove;Brian S. Snarr;Anoush Emrazian;H. Joseph Yost

  • Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.

    Xinghai Li;H.Joseph Yost;David M. Virshup;David M. Virshup;Joni M. Seeling

  • The T box transcription factor no tail in ciliated cells controls zebrafish left-right asymmetry.

    Jeffrey D Amack;H.Joseph Yost

  • RNA metabolism: strategies for regulation in the heat shock response

    H.Joseph Yost;Robert B. Petersen;Susan Linquist

  • The Left-Right Coordinator: The Role of Vg1 in Organizing Left-Right Axis Formation

    Brian A Hyatt;H.Joseph Yost

  • Lefty-dependent inhibition of Nodal- and Wnt-responsive organizer gene expression is essential for normal gastrulation.

    William W. Branford;H.Joseph Yost

  • Heparan sulfate core proteins in cell-cell signaling.

    Kenneth L. Kramer;H. Joseph Yost

Frequent Co-Authors

David M. Virshup
David M. Virshup Duke NUS Graduate Medical School
Christine E. Seidman
Christine E. Seidman Harvard University
Mark Yandell
Mark Yandell University of Utah
Richard P. Lifton
Richard P. Lifton Rockefeller University
Michael J. Bamshad
Michael J. Bamshad University of Washington
David A. Jones
David A. Jones Australian National University
Mark Leppert
Mark Leppert University of Utah
Bruce D. Gelb
Bruce D. Gelb Icahn School of Medicine at Mount Sinai
Jane W. Newburger
Jane W. Newburger Boston Children's Hospital
Jonathan G. Seidman
Jonathan G. Seidman Harvard University

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