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Biology and Biochemistry

D-Index
62
Citations
14889
World Ranking
10720
National Ranking
4655

Overview

Ralph Mazitschek is affiliated with Harvard University in the United States. Their research primarily falls within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these areas, their work is particularly concentrated on subfields such as Molecular Biology, Materials Chemistry, Organic Chemistry, Infectious Diseases, and Hematology.

The scientist has contributed to studies covering several major topics, including:

  • Protein Degradation and Inhibitors
  • Histone Deacetylase Inhibitors Research
  • Ubiquitin and proteasome pathways
  • Multiple Myeloma Research and Treatments
  • Genomics, phytochemicals, and oxidative stress
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer

Ralph Mazitschek's research has been published extensively, with frequent contributions to various journals and venues. The most common publication outlets include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell chemical biology
  • Blood
  • Analysis & Sensing
  • The Cambridge Structural Database

Selected recent papers by the scientist include:

  • "Bright and stable luminescent probes for target engagement profiling in live cells," 2021, Nature Chemical Biology
  • "Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation," 2021, iScience
  • "Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells," 2020, Proceedings of the National Academy of Sciences
  • "A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader," 2022, Cell chemical biology
  • "UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors," 2025, Nature

Collaborations are a notable aspect of Mazitschek's work. Frequent co-authors include:

  • N. Connor Payne
  • Mark A. Tye
  • Christina M. Woo
  • Madeline R. Luth
  • Taleb H. Al-Tel

Best Publications

  • HDAC2 negatively regulates memory formation and synaptic plasticity

    Ji Song Guan;Stephen J. Haggarty;Emanuela Giacometti;Jan Hermen Dannenberg;Jan Hermen Dannenberg

  • Chemical phylogenetics of histone deacetylases

    James E Bradner;Nathan West;Nathan West;Melissa L Grachan;Edward F Greenberg;Edward F Greenberg

  • Treatment of Obesity with Celastrol

    Junli Liu;Jaemin Lee;Mario Andres Salazar Hernandez;Ralph Mazitschek;Ralph Mazitschek

  • Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

    Loredana Santo;Teru Hideshima;Andrew L. Kung;Jen-Chieh Tseng

  • Bioorthogonal Turn‐On Probes for Imaging Small Molecules inside Living Cells

    Neal K. Devaraj;Scott Hilderbrand;Rabi Upadhyay;Ralph Mazitschek

  • Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response

    Mark S. Sundrud;Sergei B. Koralov;Markus Feuerer;Dinis Pedro Calado

  • Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

    Tracy L. Keller;Davide Zocco;Mark S. Sundrud;Margaret Hendrick

  • Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

    Dohoon Kim;Christopher L. Frank;Christopher L. Frank;Matthew M. Dobbin;Rachel K. Tsunemoto

  • HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions.

    Andy Dong Anh Tran;Timothy P. Marmo;Ambar A. Salam;Sally Che

  • Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

    Anja Schuetz;Jinrong Min;Jinrong Min;Abdellah Allali-Hassani;Matthieu Schapira;Matthieu Schapira

  • Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells.

    Edwin F. de Zoeten;Liqing Wang;Kyle Butler;Ulf H. Beier

  • Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6

    Yuliya Zilberman;Christoph Ballestrem;Letizia Carramusa;Letizia Carramusa;Ralph Mazitschek

  • High Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model

    Terence I. Moy;Annie L. Conery;Jonah Larkins-Ford;Gang Wu

  • Small Molecules as Inhibitors of Cyclin‐Dependent Kinases

    Axel Huwe;Ralph Mazitschek;Athanassios Giannis

  • Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

    James Elliott Bradner;Raymond Heungwing Mak;Shyam Kumar Tanguturi;Ralph Mazitschek

  • Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability.

    Jeanine Jochems;Janette Boulden;Bridgin G Lee;Julie A Blendy

  • Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation

    Anthony B. Mak;Allison M.L. Nixon;Saranya Kittanakom;Jocelyn M. Stewart;Jocelyn M. Stewart

  • Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor.

    Martina Bazzaro;Zhenhua Lin;Antonio Santillan;Michael K. Lee

  • Synthesis of [18F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging

    J. Adam Hendricks;Edmund J. Keliher;Dongpeng Wan;Scott A. Hilderbrand

  • Histone deacetylase 3 as a novel therapeutic target in multiple myeloma.

    Jiro Minami;Rikio Suzuki;Ralph Mazitschek;Gullu Gorgun

Frequent Co-Authors

James E. Bradner
James E. Bradner Amgen (United States)
Athanassios Giannis
Athanassios Giannis Leipzig University
Dyann F. Wirth
Dyann F. Wirth Harvard University
Stephen J. Haggarty
Stephen J. Haggarty Harvard University
Jon Clardy
Jon Clardy Harvard University
Teru Hideshima
Teru Hideshima Harvard University
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Malcolm Whitman
Malcolm Whitman Harvard University
Herbert Waldmann
Herbert Waldmann Max Planck Society

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