Ralph Mazitschek mainly investigates Biochemistry, Cellular differentiation, Cell biology, HDAC6 and In vivo. His work on Histone and Histone deacetylase as part of general Biochemistry study is frequently connected to Functional group, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. The concepts of his Cellular differentiation study are interwoven with issues in Amino acid, Signal transduction and Halofuginone.
Ralph Mazitschek has included themes like Experimental autoimmune encephalomyelitis, Autoimmunity and Starvation response in his Signal transduction study. Within one scientific family, Ralph Mazitschek focuses on topics pertaining to Cell cycle under Cell biology, and may sometimes address concerns connected to Proliferating cell nuclear antigen. As a part of the same scientific study, he usually deals with the In vivo, concentrating on Pharmacology and frequently concerns with Systemic administration and Mode of action.
Biochemistry, Cancer research, Cell biology, Histone deacetylase and HDAC6 are his primary areas of study. His Biochemistry research integrates issues from Plasmodium falciparum and In vivo. His studies deal with areas such as Amino acid and Small molecule as well as Cell biology.
His Histone deacetylase research includes elements of Molecular biology, Epigenetics and Acetylation. His HDAC6 research is multidisciplinary, incorporating perspectives in Deacetylase activity and Immunology. The Halofuginone study combines topics in areas such as Cellular differentiation and Drug resistance.
Ralph Mazitschek focuses on Biochemistry, Pharmacology, Cancer research, Histone deacetylase and In vivo. He performs integrative study on Biochemistry and Prolyl tRNA synthetase. His Pharmacology study incorporates themes from Cell, Obesity, Celastrol and HDAC6.
His Cancer research study combines topics from a wide range of disciplines, such as Cell growth, Downregulation and upregulation, TFEB, Neurodegeneration and Epigenetics. His work focuses on many connections between Histone deacetylase and other disciplines, such as Acetylation, that overlap with his field of interest in Neuropharmacology, Lupus nephritis and Endocrinology. His In vivo study which covers Ubiquitin that intersects with Cancer cell.
The scientist’s investigation covers issues in Cancer research, Pharmacology, Histone deacetylase, Cell growth and Kinase. In his study, which falls under the umbrella issue of Cancer research, Growth inhibition, Signal transduction, Gene knockdown and Carcinogenesis is strongly linked to Downregulation and upregulation. His Pharmacology study integrates concerns from other disciplines, such as Acetylation, CREB, Hydroxamic acid, HDAC6 and Histone.
The concepts of his Histone deacetylase study are interwoven with issues in Spindle apparatus, Deacetylase activity, Paclitaxel and Neuropharmacology. Ralph Mazitschek has researched Kinase in several fields, including Protein kinase B, Phosphorylation and PI3K/AKT/mTOR pathway. The subject of his PI3K/AKT/mTOR pathway research is within the realm of Biochemistry.
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HDAC2 negatively regulates memory formation and synaptic plasticity
Ji Song Guan;Stephen J. Haggarty;Emanuela Giacometti;Jan Hermen Dannenberg;Jan Hermen Dannenberg.
Chemical phylogenetics of histone deacetylases
James E Bradner;Nathan West;Nathan West;Melissa L Grachan;Edward F Greenberg;Edward F Greenberg.
Nature Chemical Biology (2010)
Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma
Loredana Santo;Teru Hideshima;Andrew L. Kung;Jen-Chieh Tseng.
Bioorthogonal Turn‐On Probes for Imaging Small Molecules inside Living Cells
Neal K. Devaraj;Scott Hilderbrand;Rabi Upadhyay;Ralph Mazitschek.
Angewandte Chemie (2010)
Treatment of Obesity with Celastrol
Junli Liu;Jaemin Lee;Mario Andres Salazar Hernandez;Ralph Mazitschek;Ralph Mazitschek.
Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response
Mark S. Sundrud;Sergei B. Koralov;Markus Feuerer;Dinis Pedro Calado.
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
Tracy L. Keller;Davide Zocco;Mark S. Sundrud;Margaret Hendrick.
Nature Chemical Biology (2012)
Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity
Dohoon Kim;Christopher L. Frank;Christopher L. Frank;Matthew M. Dobbin;Rachel K. Tsunemoto.
Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity
Anja Schuetz;Jinrong Min;Jinrong Min;Abdellah Allali-Hassani;Matthieu Schapira;Matthieu Schapira.
Journal of Biological Chemistry (2008)
Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells.
Edwin F. de Zoeten;Liqing Wang;Kyle Butler;Ulf H. Beier.
Molecular and Cellular Biology (2011)
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