World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
99
Citations
33049
World Ranking
439
National Ranking
48

Medicine

D-Index
99
Citations
33411
World Ranking
8645
National Ranking
847

Overview

What is he best known for?

The fields of study he is best known for:

  • Immune system
  • Internal medicine
  • Gene

Graham A. W. Rook focuses on Immunology, Tuberculosis, Immune system, Mycobacterium tuberculosis and Disease. Immunity, Hygiene hypothesis, Arthritis, Rheumatoid arthritis and Interleukin 4 are subfields of Immunology in which his conducts study. His Tuberculosis research incorporates themes from Necrosis, Pulmonary fibrosis, Pathogenesis and Vaccination.

The study incorporates disciplines such as Context, Mycobacterium bovis, Raphe nuclei and Antigen in addition to Immune system. His Mycobacterium tuberculosis study incorporates themes from Tumor necrosis factor alpha, Virology, Interferon gamma, Microbiology and Immunopathology. His studies deal with areas such as Biodiversity and Anxiety as well as Disease.

His most cited work include:

  • Validation of housekeeping genes for normalizing RNA expression in real-time PCR (841 citations)
  • The implications of using an inappropriate reference gene for real-time reverse transcription PCR data normalization (525 citations)
  • Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. (496 citations)

What are the main themes of his work throughout his whole career to date?

Graham A. W. Rook mainly investigates Immunology, Tuberculosis, Immune system, Mycobacterium tuberculosis and Antigen. The study of Immunology is intertwined with the study of Disease in a number of ways. His Tuberculosis research includes elements of Tumor necrosis factor alpha, Virology, Immunopathology and Immunotherapy.

His Immune system research focuses on Internal medicine and how it connects with Gastroenterology. His research in Mycobacterium tuberculosis intersects with topics in T cell, Lymphokine, Interferon gamma, Molecular biology and Interleukin 4. His Antigen research is multidisciplinary, relying on both Leprosy and Microbiology.

He most often published in these fields:

  • Immunology (68.85%)
  • Tuberculosis (32.08%)
  • Immune system (20.61%)

What were the highlights of his more recent work (between 2004-2021)?

  • Immunology (68.85%)
  • Immune system (20.61%)
  • Tuberculosis (32.08%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Immunology, Immune system, Tuberculosis, Mycobacterium tuberculosis and Hygiene hypothesis. The Immunology study combines topics in areas such as Disease and Inflammatory bowel disease. His Immune system study combines topics from a wide range of disciplines, such as Psychosocial, Gut flora, Early childhood and Allergy.

His work carried out in the field of Tuberculosis brings together such families of science as Immunopathology and Vaccination. Graham A. W. Rook has included themes like Tumor necrosis factor alpha, Interferon gamma, Antigen and Virology in his Mycobacterium tuberculosis study. The various areas that Graham A. W. Rook examines in his Hygiene hypothesis study include Anxiety, Multiple sclerosis, Evolutionary medicine and Hygiene.

Between 2004 and 2021, his most popular works were:

  • The implications of using an inappropriate reference gene for real-time reverse transcription PCR data normalization (525 citations)
  • Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health (311 citations)
  • Tryptophan metabolism in the central nervous system: medical implications (304 citations)

In his most recent research, the most cited papers focused on:

  • Immune system
  • Internal medicine
  • Gene

Immunology, Hygiene hypothesis, Immune system, Tuberculosis and Inflammatory bowel disease are his primary areas of study. His research brings together the fields of Disease and Immunology. The concepts of his Hygiene hypothesis study are interwoven with issues in Proinflammatory cytokine, Multiple sclerosis and Depression.

His Immune system study combines topics in areas such as Raphe, Context, Neuroscience and Environmental exposure. Graham A. W. Rook has researched Tuberculosis in several fields, including Pulmonary fibrosis and Lung. Graham A. W. Rook combines subjects such as Inflammation, Autoimmunity, Prebiotic and Probiotic with his study of Inflammatory bowel disease.

Best Publications

  • Validation of housekeeping genes for normalizing RNA expression in real-time PCR

    Keertan Dheda;Jim F. Huggett;Stephen A. Bustin;Margaret A. Johnson

  • Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health

    Graham A. Rook

  • The implications of using an inappropriate reference gene for real-time reverse transcription PCR data normalization

    K. Dheda;J.F. Huggett;J.S. Chang;L.U. Kim

  • Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes

    Graham Rook;J Steele;L Fraher;S Barker

  • Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells.

    Claudia Zuany-Amorim;Elzbieta Sawicka;Elzbieta Sawicka;Corinne Manlius;Alain Le Moine

  • Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection.

    R. Hernández-Pando;M. Jeyanathan;G. Mengistu;D. Aguilar

  • Tryptophan metabolism in the central nervous system: medical implications

    Jon P. Ruddick;Andrew K. Evans;David J. Nutt;Stafford L. Lightman

  • GIVE US THIS DAY OUR DAILY GERMS

    Graham A.W. Rook;John L. Stanford

  • Hygiene Hypothesis and Autoimmune Diseases

    Graham A. W. Rook

  • Microbes, immunoregulation, and the gut

    G A W Rook;L R Brunet

  • Regulation of inflammation by interleukin-4: a review of "alternatives".

    Irina G. Luzina;Irina G. Luzina;Achsah D. Keegan;Nicola M. Heller;Graham A. W. Rook

  • A simple method for the solubilisation of reduced NBT, and its use as a colorimetric assay for activation of human macrophages by γ-interferon

    G.A.W. Rook;J. Steele;S. Umar;H.M. Dockrell

  • 99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Darwinian medicine and the ‘hygiene’ or ‘old friends’ hypothesis

    G. A. W. Rook

  • Review series on helminths, immune modulation and the hygiene hypothesis: the broader implications of the hygiene hypothesis.

    Graham A. W. Rook

  • The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems

    Lucette Flandroy;Theofilos Poutahidis;Gabriele Berg;Gerard Clarke

  • Mechanisms of disease: the hygiene hypothesis revisited.

    Francisco Guarner;Raphaëlle Bourdet-Sicard;Per Brandtzaeg;Harsharnjit S. Gill

  • Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance

    Graham A.W. Rook;Rogelio Hernandez-Pando;Stafford L. Lightman

  • Lung Remodeling in Pulmonary Tuberculosis

    Keertan Dheda;Helen Booth;Jim F. Huggett;Margaret A. Johnson

  • ACTIVATION OF MACROPHAGES TO INHIBIT PROLIFERATION OF MYCOBACTERIUM-TUBERCULOSIS - COMPARISON OF THE EFFECTS OF RECOMBINANT GAMMA-INTERFERON ON HUMAN-MONOCYTES AND MURINE PERITONEAL-MACROPHAGES

    G. A. W. Rook;J. Steele;M. Ainsworth;B. R. Champion

  • Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG.

    C. Abou-Zeid;T. L. Ratliff;H. G. Wiker;M. Harboe

Frequent Co-Authors

Alimuddin Zumla
Alimuddin Zumla University College London
Keertan Dheda
Keertan Dheda University of Cape Town
Rogelio Hernández-Pando
Rogelio Hernández-Pando Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Jim F. Huggett
Jim F. Huggett University College London
Stafford L. Lightman
Stafford L. Lightman University of Bristol
Margaret Johnson
Margaret Johnson The Royal Free Hospital
T. Mark Doherty
T. Mark Doherty Danish Institute for Study Abroad
Peter E. Andersen
Peter E. Andersen Technical University of Denmark
Abraham Aseffa
Abraham Aseffa Armauer Hansen Research Institute
Anthony Meager
Anthony Meager National Institute for Biological Standards and Control

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