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George E. O. Muscat

George E. O. Muscat

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
13839
World Ranking
8330
National Ranking
209

Overview

George E. O. Muscat is a researcher affiliated with the University of Queensland in Australia. Their work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broad areas, Muscat's research is concentrated on several subfields including Molecular Biology, Oncology, Genetics, Cancer Research, and Physiology.

Their research topics cover a range of biological and medical phenomena, particularly focusing on the lymphatic system and its diseases, angiogenesis and VEGF in cancer, cancer cells and metastasis, estrogen and related hormone effects, retinoids in leukemia and cellular processes, cancer, lipids and metabolism, and adipose tissue and metabolism.

Muscat has contributed to several publications, including:

  • A tumour suppressive relationship between mineralocorticoid and retinoic acid receptors activates a transcriptional program consistent with a reverse Warburg effect in breast cancer (2020, Breast Cancer Research)
  • Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice (2024, Journal of Sport and Health Science)
  • Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesity (2022, bioRxiv, Cold Spring Harbor Laboratory)

Frequent co-authors in their work include Marit Hjorth, Casey L. Egan, Guilherme Defante Telles, Martin Pál, and David Gallego-Ortega. These collaborations suggest a multidisciplinary approach and engagement with researchers specializing in related biomedical fields.

Muscat's research has been published in venues such as the Journal of Sport and Health Science, Breast Cancer Research, and bioRxiv at Cold Spring Harbor Laboratory. This range of journals reflects an intersection of cancer biology, molecular biology, and health sciences in their work.

Best Publications

  • A human beta-actin expression vector system directs high-level accumulation of antisense transcripts

    Peter Gunning;John Leavitt;George Muscat;Sun-Yu Ng

  • SOX9 Binds DNA, Activates Transcription, and Coexpresses with Type II Collagen during Chondrogenesis in the Mouse

    Ling-Jim Ng;Susan Wheatley;George E.O Muscat;John Conway-Campbell

  • Sox18 induces development of the lymphatic vasculature in mice

    Mathias Francois;Andrea Caprini;Brett Hosking;Fabrizio Orsenigo

  • The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells

    Uwe Dressel;Tamara L. Allen;Jyotsna B. Pippal;Paul R. Rohde

  • The NR4A subgroup: immediate early response genes with pleiotropic physiological roles.

    Megan A. Maxwell;George E.O. Muscat

  • Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease

    Michael A. Pearen;George E. O. Muscat

  • A dynamic role for HDAC7 in MEF2-mediated muscle differentiation.

    Uwe Dressel;Peter J. Bailey;Shu-Ching M. Wang;Michael Downes

  • International Union of Pharmacology. LXVI. Orphan Nuclear Receptors

    Gérard Benoit;Austin Cooney;Vincent Giguere;Holly Ingraham

  • Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis

    Pier Lorenzo Puri;Pier Lorenzo Puri;Simona Iezzi;Peter Stiegler;Tung Ti Chen

  • Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice.

    David J. Pennisi;Jennifer Gardner;Doreen Chambers;Brett Hosking

  • Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes

    Angélica Figueroa;Ana Cuadrado;Jinshui Fan;Ulus Atasoy

  • The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity.

    Patrick Lau;Rebecca L. Fitzsimmons;Suryaprakash Raichur;Shu-Ching M. Wang

  • Adenovirus E1A products suppress myogenic differentiation and inhibit transcription from muscle-specific promoters

    Keith A. Webster;George E. O. Muscat;Larry Kedes

  • Skeletal muscle and nuclear hormone receptors: implications for cardiovascular and metabolic disease.

    Aaron G. Smith;George E.O. Muscat

  • RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR.

    Patrick Lau;Susan J. Nixon;Robert G. Parton;George E.O. Muscat

  • Multiple 5'-flanking regions of the human alpha-skeletal actin gene synergistically modulate muscle-specific expression.

    G. E. O. Muscat;L. Kedes

  • The coactivator-associated arginine methyltransferase is necessary for muscle differentiation - CARM1 coactivates myocyte enhancer factor-2

    Shen Liang Chen;Kelly A. Loffler;Dagang Chen;Michael R. Stallcup

  • The AF-1 Domain of the Orphan Nuclear Receptor NOR-1 Mediates Trans-activation, Coactivator Recruitment, and Activation by the Purine Anti-metabolite 6-Mercaptopurine

    K. D. Senali Abayratna Wansa;Jonathan M. Harris;Grace Yan;Peter Ordentlich

  • The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation

    Shen Liang Chen;Dennis H. Dowhan;Brett M. Hosking;George E.O. Muscat

  • Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway.

    Megan A. Maxwell;Mark E. Cleasby;Angus Harding;Annika Stark

Frequent Co-Authors

Peter Koopman
Peter Koopman University of Queensland
Wayne D. Tilley
Wayne D. Tilley University of Adelaide
Larry Kedes
Larry Kedes University of Southern California
John W. Funder
John W. Funder Hudson Institute of Medical Research
Richard A. Sturm
Richard A. Sturm University of Queensland
Michael J. Waters
Michael J. Waters University of Queensland
Evan R. Simpson
Evan R. Simpson Hudson Institute of Medical Research
Evan R. Simpson
Evan R. Simpson Hudson Institute of Medical Research
Peter E. Lobie
Peter E. Lobie Tsinghua University
Sean M. Grimmond
Sean M. Grimmond University of Melbourne

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