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Stephen J. Haggarty

Stephen J. Haggarty

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
36748
World Ranking
4928
National Ranking
2367

Overview

Stephen J. Haggarty is affiliated with Harvard University in the United States and primarily conducts research within the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work extensively covers subfields including Molecular Biology, Neurology, Physiology, Cancer Research, and Cell Biology.

The scientific topics of Stephen J. Haggarty's research include:

  • Alzheimer's disease research and treatments
  • Pluripotent Stem Cells Research
  • MicroRNA in disease regulation
  • Amyotrophic Lateral Sclerosis Research
  • Histone Deacetylase Inhibitors Research
  • RNA Research and Splicing
  • Protein Degradation and Inhibitors

Recent significant publications by Stephen J. Haggarty include the following:

  • HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease, 2020, Nature Communications
  • A psychiatric disease-related circular RNA controls synaptic gene expression and cognition, 2020, Molecular Psychiatry
  • ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids, 2021, Cell
  • Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons, 2020, Nature Communications
  • Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies, 2020, International Journal of Molecular Sciences

Frequent co-authors collaborating with Stephen J. Haggarty are:

  • M. Catarina Silva
  • Debasis Patnaik
  • Li-Huei Tsai
  • Jasmin Lalonde
  • Roy H. Perlis

Stephen J. Haggarty's work appears regularly in several scientific journals. The most frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Molecular Psychiatry
  • iScience
  • Proceedings of the National Academy of Sciences

Best Publications

  • The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

    Justin Lamb;Emily D. Crawford;David Peck;Joshua W. Modell

  • A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

    Aravind Subramanian;Rajiv Narayan;Steven M. Corsello;Steven M. Corsello;David D. Peck

  • Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

    Thomas U. Mayer;Tarun M. Kapoor;Stephen J. Haggarty;Stephen J. Haggarty;Randall W. King

  • HDAC2 negatively regulates memory formation and synaptic plasticity

    Ji Song Guan;Stephen J. Haggarty;Emanuela Giacometti;Jan Hermen Dannenberg;Jan Hermen Dannenberg

  • A polygenic burden of rare disruptive mutations in schizophrenia

    Shaun M Purcell;Jennifer L Moran;Menachem Fromer;Douglas Ruderfer

  • Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

    Stephen J. Haggarty;Kathryn M. Koeller;Jason C. Wong;Christina M. Grozinger

  • An epigenetic blockade of cognitive functions in the neurodegenerating brain

    Johannes Gräff;Damien Rei;Damien Rei;Ji-Song Guan;Ji-Song Guan;Wen-Yuan Wang;Wen-Yuan Wang

  • Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

    Yingwei Mao;Xuecai Ge;Xuecai Ge;Xuecai Ge;Christopher L. Frank;Christopher L. Frank;Jon M. Madison

  • Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease.

    Mark Kilgore;Courtney A Miller;Daniel M Fass;Daniel M Fass;Krista M Hennig;Krista M Hennig

  • Chemical phylogenetics of histone deacetylases

    James E Bradner;Nathan West;Nathan West;Melissa L Grachan;Edward F Greenberg;Edward F Greenberg

  • Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

    Jason Rihel;David A. Prober;Anthony Arvanites;Kelvin Lam

  • Essential Role of the Histone Methyltransferase G9a in Cocaine-induced Plasticity

    Ian Maze;Herbert E. Iii. Covington;David M. Dietz;Quincey LaPlant;Quincey LaPlant

  • Antidepressant actions of histone deacetylase inhibitors.

    Herbert E. Covington;Ian Maze;Quincey C. LaPlant;Vincent F. Vialou

  • Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli

    William Renthal;Ian Maze;Vaishnav Krishnan;Herbert E. Covington

  • Rapid behavior-based identification of neuroactive small molecules in the zebrafish

    David Kokel;Jennifer Bryan;Christian Laggner;Rick White

  • Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis.

    Stephen J Haggarty;Stephen J Haggarty;Thomas U Mayer;David T Miyamoto;Reza Fathi

  • Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

    Johannes Gräff;Nadine F. Joseph;Nadine F. Joseph;Meryl E. Horn;Alireza Samiei

  • Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

    Dohoon Kim;Christopher L. Frank;Christopher L. Frank;Matthew M. Dobbin;Rachel K. Tsunemoto

  • Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome

    Steven D. Sheridan;Kraig M. Theriault;Surya A. Reis;Surya A. Reis;Fen Zhou;Fen Zhou

  • An epigenetic blockade of cognitive functions in the neurodegenerating brain

    Damien Rei;Ji-Song Guan;Wen-Yuan Wang;Jinsoo Seo

Frequent Co-Authors

Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Roy H. Perlis
Roy H. Perlis Harvard University
Ralph Mazitschek
Ralph Mazitschek Harvard University
Edward M. Scolnick
Edward M. Scolnick Broad Institute
James F. Gusella
James F. Gusella Harvard University
Michael E. Talkowski
Michael E. Talkowski Harvard University
Shaun Purcell
Shaun Purcell Harvard Medical School
Timothy J. Mitchison
Timothy J. Mitchison Harvard University

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