World's Best Scientists 2026 revealed!

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Immunology

D-Index
124
Citations
50133
World Ranking
301
National Ranking
190

Medicine

D-Index
124
Citations
50217
World Ranking
3246
National Ranking
1789

Overview

Wayne W. Hancock is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology. Within these broader areas, they have contributed extensively to subfields such as immunology, molecular biology, oncology, surgery, and genetics.

The scientist has focused research on topics including:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Histone Deacetylase Inhibitors Research
  • CAR-T Cell Therapy Research
  • Immune Response and Inflammation
  • Immune Cells in Cancer
  • Acute Lymphoblastic Leukemia Research

Wayne W. Hancock has published recent papers addressing various aspects of immune cell function and regulation. Notable publications include:

  • "Lactate Limits T Cell Proliferation via the NAD(H) Redox State," 2020, Cell Reports
  • "HDAC10 Deletion Promotes Foxp3+ T-regulatory Cell Function," 2020, Scientific Reports
  • "Inhibiting the Coregulator CoREST Impairs Foxp3+ Treg Function and Promotes Antitumor Immunity," 2020, Journal of Clinical Investigation
  • "Kynurenine Induces T Cell Fat Catabolism and Has Limited Suppressive Effects In Vivo," 2021, EBioMedicine
  • "Obesity-related IL-18 Impairs T-Regulatory Cell Function and Promotes Lung Ischemia-Reperfusion Injury," 2021, American Journal of Respiratory and Critical Care Medicine

Frequent coauthors in their work include Liqing Wang, Tatiana Akimova, Lanette M. Christensen, Matthew H. Levine, and Ulf H. Beier. Collaborative publications with these researchers indicate a networked approach to advancing immunological and clinical science.

The scientist has published in several venues multiple times, notable ones being:

  • Cancer Research
  • American Journal of Transplantation
  • Frontiers in Immunology
  • Scientific Reports
  • Journal of Clinical Investigation

Best Publications

  • Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4

    Stephen T. Smiley;Jennifer A. King;Wayne W. Hancock;Wayne W. Hancock

  • Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

    Alessia Angelin;Luis Gil-de-Gómez;Satinder Dahiya;Jing Jiao

  • CCR5+ and CXCR3+ T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions

    Konstantin E. Balashov;James B. Rottman;Howard L. Weiner;Wayne W. Hancock

  • Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

    S J Khoury;W W Hancock;H L Weiner

  • Deacetylase inhibition promotes the generation and function of regulatory T cells

    Ran Tao;Edwin F de Zoeten;Engin Özkaynak;Chunxia Chen

  • Requirement of the Chemokine Receptor CXCR3 for Acute Allograft Rejection

    Wayne W. Hancock;Bao Lu;Wei Gao;Vilmos Csizmadia

  • Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.

    Andrew D. Wells;Xian Chang Li;Yongsheng Li;Matthew C. Walsh

  • Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer.

    Evgeniy B. Eruslanov;Pratik S. Bhojnagarwala;Jon G. Quatromoni;Tom Li Stephen

  • CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

    Mohamed H. Sayegh;Enver Akalin;Wayne W. Hancock;Mary E. Russell

  • Messenger RNA for FOXP3 in the Urine of Renal-Allograft Recipients

    Thangamani Muthukumar;Darshana Dadhania;Ruchuang Ding;Catherine Snopkowski

  • Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes.

    Wayne W. Hancock;Roland Buelow;Mohamed H. Sayegh;Laurence A. Turka

  • Accommodation of vascularized xenografts: Expression of “protective genes” by donor endothelial cells in a host Th2 cytokine environment

    Bach Fh;Ferran C;Hechenleitner P;Mark W

  • Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

    Wayne W. Hancock;Mohamed H. Sayegh;Xiang Guang Zheng;Robert Peach

  • Effects of explosive brain death on cytokine activation of peripheral organs in the rat.

    Moriatsu Takada;Kari C. Nadeau;Wayne W. Hancock;Harald S. Mackenzie

  • Helios Expression Is a Marker of T Cell Activation and Proliferation

    Tatiana Akimova;Ulf H. Beier;Liqing Wang;Matthew H. Levine

  • FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

    Bin Li;Arabinda Samanta;Xiaomin Song;Kathryn T. Iacono

  • Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

    Sunil Singhal;Sunil Singhal;Pratik S. Bhojnagarwala;Shaun O'Brien;Edmund K. Moon

  • Homeostatic proliferation is a barrier to transplantation tolerance

    Zihao Wu;Steven J Bensinger;Jidong Zhang;Chuangqi Chen

  • Delayed xenograft rejection

    Fritz H. Bach;Hans Winkler;Christiane Ferran;Wayne W. Hancock

  • Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor

    Iris Lee;Liqing Wang;Andrew D. Wells;Martin E. Dorf

  • Nasal administration of amyloid‐β peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease

    Howard L. Weiner;Cynthia A. Lemere;Ruth Maron;Edward T. Spooner

  • Donor-Derived Ip-10 Initiates Development of Acute Allograft Rejection

    Wayne W. Hancock;Wei Gao;Vilmos Csizmadia;Kerrie L. Faia

Frequent Co-Authors

Nicholas L. Tilney
Nicholas L. Tilney Brigham and Women's Hospital
Mohamed H. Sayegh
Mohamed H. Sayegh American University of Beirut
Jerzy W. Kupiec-Weglinski
Jerzy W. Kupiec-Weglinski University of California, Los Angeles
Fritz H. Bach
Fritz H. Bach Harvard Medical School
Laurence A. Turka
Laurence A. Turka Harvard University
Howard L. Weiner
Howard L. Weiner Harvard University
Simon C. Robson
Simon C. Robson Beth Israel Deaconess Medical Center
Andrew D. Wells
Andrew D. Wells Children's Hospital of Philadelphia
Steven M. Albelda
Steven M. Albelda University of Pennsylvania
Charles B. Carpenter
Charles B. Carpenter Brigham and Women's Hospital

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