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Genetics

D-Index
81
Citations
48511
World Ranking
1492
National Ranking
698

Overview

Timothy H. Bestor is affiliated with Columbia University in the United States and conducts research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans multiple subfields including Genetics, Plant Science, and Molecular Biology.

The scientist's main topics of research include Chromosomal and Genetic Variations, RNA modifications and cancer, Genetics and Neurodevelopmental Disorders, Nutrition, Genetics, and Disease, and BRCA gene mutations in cancer.

Timothy H. Bestor has published in several venues, with notable appearances in the Proceedings of the National Academy of Sciences and UNC Libraries. Two recent papers highlight the scope of their research interests:

  • Methylation-directed glycosylation of chromatin factors represses retrotransposon promoters, 2020, Proceedings of the National Academy of Sciences
  • BRCA1 promoter methylation is associated with increased mortality among women with breast cancer, 2020, UNC Libraries

The scientist has collaborated frequently with other researchers including Mathieu Boulard, Sofia Rucli, John R. Edwards, Xinran Xu, and Marilie D. Gammon, contributing to interdisciplinary projects and expanding the depth of their research network.

Best Publications

  • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.

    En Li;Timothy H. Bestor;Rudolf Jaenisch

  • The DNA methyltransferases of mammals

    Timothy H. Bestor

  • Eukaryotic cytosine methyltransferases.

    Mary Grace Goll;Timothy H. Bestor

  • Cytosine methylation and the ecology of intragenomic parasites

    Jeffrey A. Yoder;Colum P. Walsh;Timothy H. Bestor

  • DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.

    Steen K.T. Ooi;Chen Qiu;Emily Bernstein;Keqin Li

  • Dnmt3L and the establishment of maternal genomic imprints.

    Déborah Bourc'his;Guo-Liang Xu;Chyuan-Sheng Lin;Brooke Bollman

  • Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene.

    Guo-Liang Xu;Timothy H. Bestor;Déborah Bourc'his;Chih-Lin Hsieh

  • Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L.

    Déborah Bourc'his;Timothy H. Bestor

  • Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2

    Mary Grace Goll;Finn Kirpekar;Keith A. Maggert;Jeffrey A. Yoder

  • Transcription of IAP endogenous retroviruses is constrained by cytosine methylation

    CP Walsh;JR Chaillet;TH Bestor

  • A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

    Heinrich Leonhardt;Andrea W. Page;Heinz-Ulrich Weier;Timothy H. Bestor

  • A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.

    Alexei A. Aravin;Alexei A. Aravin;Ravi Sachidanandam;Ravi Sachidanandam;Deborah Bourc'his;Christopher Schaefer;Christopher Schaefer

  • Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells: The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases☆

    Timothy Bestor;Andrew Laudano;Robert Mattaliano;Vernon Ingram

  • MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.

    Michelle A. Carmell;Angélique Girard;Angélique Girard;Henk J.G. van de Kant;Deborah Bourc'his

  • A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes

    Richard J. Roberts;Marlene Belfort;Timothy Bestor;Ashok S. Bhagwat

  • Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene

    Carina Y. Howell;Timothy H. Bestor;Feng Ding;Keith E. Latham

  • The Colorful History of Active DNA Demethylation

    Steen K.T. Ooi;Timothy H. Bestor

  • Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.

    T.H. Bestor

  • Methylation Dynamics of Imprinted Genes in Mouse Germ Cells

    Diana Lucifero;Carmen Mertineit;Carmen Mertineit;Carmen Mertineit;Hugh J. Clarke;Hugh J. Clarke;Hugh J. Clarke;Timothy H. Bestor;Timothy H. Bestor;Timothy H. Bestor

  • Cytosine methylation and mammalian development

    Colum P. Walsh;Timothy H. Bestor

Frequent Co-Authors

Déborah Bourc'his
Déborah Bourc'his Institute Curie
Jingyue Ju
Jingyue Ju Columbia University
Benjamin Tycko
Benjamin Tycko Hackensack University Medical Center
Xiaodong Cheng
Xiaodong Cheng The University of Texas MD Anderson Cancer Center
Gregory J. Hannon
Gregory J. Hannon University of Cambridge
Chih-Lin Hsieh
Chih-Lin Hsieh University of Southern California
Guoliang Xu
Guoliang Xu Fudan University
Heinrich Leonhardt
Heinrich Leonhardt Ludwig-Maximilians-Universität München
Dirk G. de Rooij
Dirk G. de Rooij Utrecht University

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