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Molecular Biology

D-Index
60
Citations
19160
World Ranking
1932
National Ranking
959

Overview

Chih-Lin Hsieh is affiliated with the University of Southern California in the United States. Their research predominantly covers the fields of Biochemistry, Genetics, and Molecular Biology, with additional work in Medicine.

The scientist has made contributions to several subfields including Molecular Biology, Genetics, Public Health, Environmental and Occupational Health, Immunology, and Oncology.

Their main research topics encompass:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Acute Lymphoblastic Leukemia research
  • Cancer therapeutics and mechanisms
  • Genetics and Neurodevelopmental Disorders
  • T-cell and B-cell Immunology
  • Pluripotent Stem Cells Research

Chih-Lin Hsieh has published in various scientific venues, notably:

  • UNC Libraries
  • Molecular Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • American Journal of Physiology-Lung Cellular and Molecular Physiology
  • Cell Reports

Recent papers authored or co-authored by Chih-Lin Hsieh include:

  • Derivation of induced pluripotent stem cells from ferret somatic cells, 2020, American Journal of Physiology-Lung Cellular and Molecular Physiology
  • DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination, 2020, Molecular Immunology
  • Mechanistic basis for chromosomal translocations at the E2A gene and its broader relevance to human B cell malignancies, 2021, Cell Reports
  • The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination, 2021, DNA repair
  • Artemis inhibition as a therapeutic strategy for acute lymphoblastic leukemia, 2023, Frontiers in Cell and Developmental Biology

Frequent collaborators include researchers such as Michael R. Lieber, Cindy Yen Okitsu, D Liu, Zarko Manojlovic, and Jordan Wlodarczyk.

Best Publications

  • REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants

    Nilah M M. Ioannidis;Joseph H H. Rothstein;Joseph H H. Rothstein;Vikas Pejaver;Sumit Middha

  • Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene.

    Guo-Liang Xu;Timothy H. Bestor;Déborah Bourc'his;Chih-Lin Hsieh

  • Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2

    Mary Grace Goll;Finn Kirpekar;Keith A. Maggert;Jeffrey A. Yoder

  • Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts

    Ping Li;Chang Tong;Ruty Mehrian-Shai;Li Jia

  • R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

    Kefei Yu;Frederic Chedin;Chih Lin Hsieh;Thomas E. Wilson

  • Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis.

    James J. Cali;Chih Lin Hsieh;Chih Lin Hsieh;Uta Francke;Uta Francke;David W. Russell

  • The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a

    Frédéric Chédin;Michael R. Lieber;Chih-Lin Hsieh

  • Loss of Imprinting in Colorectal Cancer Linked to Hypomethylation of H19 and IGF2

    Hengmi Cui;Patrick Onyango;Sheri Brandenburg;Yiqian Wu

  • A Biochemically Defined System for Mammalian Nonhomologous DNA End Joining

    Yunmei Ma;Haihui Lu;Brigette Tippin;Myron F. Goodman

  • Dependence of transcriptional repression on CpG methylation density.

    Chih-Lin Hsieh

  • In Vivo Activity of Murine De Novo Methyltransferases, Dnmt3a and Dnmt3b

    Chih-Lin Hsieh

  • Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA.

    Xiantuo Wu;Jun Li;Xiangyang Li;Chih-Lin Hsieh

  • A regular pattern of two types of 100-residue motif in the sequence of titin.

    S. Labeit;D. P. Barlow;M. Gautel;T. Gibson

  • A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex.

    Sathees C. Raghavan;Patrick C. Swanson;Xlantuo Wu;Chih Lin Hsieh

  • Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family

    Zhao Xia Chen;Jeffrey R. Mann;Chih Lin Hsieh;Arthur D. Riggs

  • Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for their Lineage and Stage Specificity

    Albert G. Tsai;Haihui Lu;Sathees C. Raghavan;Markus Muschen

  • Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants

    Zarir E Karanjawala;Niamh Murphy;David R Hinton;Chih Lin Hsieh

  • HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG)

    Jianfeng Xu;Ethan M. Lange;Ethan M. Lange;Lingyi Lu;Siqun L. Zheng

  • CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication.

    Chih-Lin Hsieh;M. R. Lieber

  • DNA Methylation Dictates Histone H3K4 Methylation

    Cindy Yen Okitsu;Chih-Lin Hsieh

Frequent Co-Authors

Michael R. Lieber
Michael R. Lieber University of Southern California
Uta Francke
Uta Francke Stanford University
Graham G. Giles
Graham G. Giles University of Melbourne
Elaine A. Ostrander
Elaine A. Ostrander National Institutes of Health
Ethan M. Lange
Ethan M. Lange University of Colorado Anschutz Medical Campus
Alice S. Whittemore
Alice S. Whittemore Stanford University
Fredrik Wiklund
Fredrik Wiklund Karolinska Institute
Johanna Schleutker
Johanna Schleutker Turku University Hospital
Joan E. Bailey-Wilson
Joan E. Bailey-Wilson National Institutes of Health
Lisa A. Cannon-Albright
Lisa A. Cannon-Albright University of Utah

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