D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 55 Citations 14,214 103 World Ranking 3086 National Ranking 1475

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Enzyme

Chih-Lin Hsieh mainly focuses on Molecular biology, DNA methylation, Genetics, DNA and Methyltransferase. Chih-Lin Hsieh has included themes like Superoxide dismutase, SOD1, Chromosome, In vivo and DNA replication in his Molecular biology study. Many of his studies on DNA methylation apply to Methylation as well.

His work in the fields of Exome, Allele frequency and Mutation overlaps with other areas such as Ensemble learning and Overall performance. Chih-Lin Hsieh interconnects Human genome, Breakpoint, Gene, Chromosomal translocation and CpG site in the investigation of issues within DNA. His work is dedicated to discovering how Methyltransferase, Genomic imprinting are connected with Epigenetics and other disciplines.

His most cited work include:

  • Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. (983 citations)
  • Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2 (757 citations)
  • Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts (582 citations)

What are the main themes of his work throughout his whole career to date?

Chih-Lin Hsieh focuses on Molecular biology, Genetics, DNA, DNA methylation and Gene. His Molecular biology research incorporates elements of Transgene, Biochemistry, Complementary DNA, DNA repair and Gene mapping. In his research, Embryonic stem cell and Cellular differentiation is intimately related to Cell biology, which falls under the overarching field of Genetics.

His study focuses on the intersection of DNA and fields such as Chromosomal translocation with connections in the field of Chromosomal fragile site. The DNA methylation study combines topics in areas such as Methylation and Methyltransferase. He studied Methyltransferase and Genomic imprinting that intersect with Epigenetics.

He most often published in these fields:

  • Molecular biology (55.56%)
  • Genetics (46.15%)
  • DNA (23.93%)

What were the highlights of his more recent work (between 2013-2021)?

  • Genetics (46.15%)
  • Molecular biology (55.56%)
  • DNA (23.93%)

In recent papers he was focusing on the following fields of study:

Chih-Lin Hsieh mostly deals with Genetics, Molecular biology, DNA, DNA methylation and Computational biology. His research ties Bioinformatics and Genetics together. In his work, he performs multidisciplinary research in Molecular biology and RNA silencing.

His DNA research is multidisciplinary, relying on both Chromosomal fragile site, Nuclear gene, Methylated DNA immunoprecipitation and DNA End-Joining Repair. His DNA methylation study incorporates themes from Chromosomal translocation, Footprinting, Chromatin, Methyltransferase and Chromosome Fragile Site. His research integrates issues of Association test, Locus and Cohort in his study of Computational biology.

Between 2013 and 2021, his most popular works were:

  • REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants (546 citations)
  • Complexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids (29 citations)
  • The strength of an Ig switch region is determined by its ability to drive R loop formation and its number of WGCW sites. (27 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Enzyme

His primary scientific interests are in Genetics, Molecular biology, Genome-wide association study, Bioinformatics and Familial prostate cancer. He performs integrative study on Genetics and Ensemble learning. His studies in Molecular biology integrate themes in fields like R-loop, Immunoglobulin class switching, Biophysics, Nucleotide and Absolute number.

He has researched Genome-wide association study in several fields, including Prostate cancer, Human genetics, Genetic association and Medical genetics. As part of his studies on Bioinformatics, Chih-Lin Hsieh often connects relevant areas like Family history.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene.

Guo-Liang Xu;Timothy H. Bestor;Déborah Bourc'his;Chih-Lin Hsieh.
Nature (1999)

1304 Citations

Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2

Mary Grace Goll;Finn Kirpekar;Keith A. Maggert;Jeffrey A. Yoder.
Science (2006)

1118 Citations

Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts

Ping Li;Chang Tong;Ruty Mehrian-Shai;Li Jia.
Cell (2008)

906 Citations

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

Kefei Yu;Frederic Chedin;Chih Lin Hsieh;Thomas E. Wilson.
Nature Immunology (2003)

673 Citations

Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis.

James J. Cali;Chih Lin Hsieh;Chih Lin Hsieh;Uta Francke;Uta Francke;David W. Russell.
Journal of Biological Chemistry (1991)

575 Citations

The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a

Frédéric Chédin;Michael R. Lieber;Chih-Lin Hsieh.
Proceedings of the National Academy of Sciences of the United States of America (2002)

528 Citations

Loss of Imprinting in Colorectal Cancer Linked to Hypomethylation of H19 and IGF2

Hengmi Cui;Patrick Onyango;Sheri Brandenburg;Yiqian Wu.
Cancer Research (2002)

460 Citations

Dependence of transcriptional repression on CpG methylation density.

Chih-Lin Hsieh.
Molecular and Cellular Biology (1994)

434 Citations

REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants

Nilah M M. Ioannidis;Joseph H H. Rothstein;Joseph H H. Rothstein;Vikas Pejaver;Sumit Middha.
American Journal of Human Genetics (2016)

421 Citations

A Biochemically Defined System for Mammalian Nonhomologous DNA End Joining

Yunmei Ma;Haihui Lu;Brigette Tippin;Myron F. Goodman.
Molecular Cell (2004)

413 Citations

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