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Genetics

D-Index
81
Citations
26926
World Ranking
1516
National Ranking
116

Overview

Frank Lyko is affiliated with the German Cancer Research Center in Germany and has contributed extensively to the field of Biochemistry, Genetics, and Molecular Biology. Their research primarily spans Molecular Biology, Ecology, Genetics, Oncology, and Cancer Research, with a focused interest in epigenetic mechanisms and cancer-related molecular pathways.

The scientist's main research topics include:

  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Crustacean biology and ecology
  • Cancer-related gene regulation
  • Cancer-related molecular mechanisms research
  • Aquaculture Nutrition and Growth
  • Skin Protection and Aging

Frequent coauthors collaborating with Frank Lyko are:

  • Günter Raddatz
  • Manuel Rodríguez-Paredes
  • Julian Gutekunst
  • Mark Helm
  • Florian Böhl

The scientist's recent peer-reviewed publications include:

  • Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming (2020), Communications Biology
  • The microbiota programs DNA methylation to control intestinal homeostasis and inflammation (2020), Nature Microbiology
  • Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome (2020), Genome Medicine
  • Rapid Epigenetic Adaptation in Animals and Its Role in Invasiveness (2020), Integrative and Comparative Biology
  • Queuosine-tRNA promotes sex-dependent learning and memory formation by maintaining codon-biased translation elongation speed (2023), The EMBO Journal

Frank Lyko has published frequently in several scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Communications Biology
  • Cancer Research
  • The EMBO Journal
  • Nature Communications

Best Publications

  • The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

    Frank Lyko

  • Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a

    Bernard H. Ramsahoye;Detlev Biniszkiewicz;Frank Lyko;Victoria Clark

  • Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

    Carlo Stresemann;Frank Lyko

  • Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation

    Guillermo Barreto;Andrea Schäfer;Joachim Marhold;Dirk Stach

  • The honey bee epigenomes: differential methylation of brain DNA in queens and workers.

    Frank Lyko;Sylvain Foret;Robert Kucharski;Stephan Wolf

  • RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

    Matthias Schaefer;Tim Pollex;Katharina Hanna;Francesca Tuorto

  • DNA methylation in Drosophila melanogaster

    Frank Lyko;Bernard H. Ramsahoye;Rudolf Jaenisch

  • The Human let-7a-3 Locus Contains an Epigenetically Regulated MicroRNA Gene with Oncogenic Function

    Bodo Brueckner;Carlo Stresemann;Ruprecht Kuner;Cora Mund

  • Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

    Bodo Brueckner;Regine Garcia Boy;Pawel Siedlecki;Pawel Siedlecki;Tanja Musch

  • RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.

    Francesca Tuorto;Reinhard Liebers;Tanja Musch;Matthias Schaefer

  • Methylation of human microRNA genes in normal and neoplastic cells

    Barbara Weber;Carlo Stresemann;Bodo Brueckner;Frank Lyko

  • Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.

    Yunfang Zhang;Yunfang Zhang;Xudong Zhang;Junchao Shi;Francesca Tuorto

  • Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond

    Achim Breiling;Frank Lyko

  • Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

    Llorenç Solé-Boldo;Günter Raddatz;Sabrina Schütz;Jan-Philipp Mallm

  • 5-methylcytosine in RNA: detection, enzymatic formation and biological functions.

    Yuri Motorin;Frank Lyko;Mark Helm

  • Aging and chronic sun exposure cause distinct epigenetic changes in human skin.

    Elke Grönniger;Barbara Weber;Oliver Heil;Nils Peters

  • LUMA (LUminometric Methylation Assay)--a high throughput method to the analysis of genomic DNA methylation.

    Mohsen Karimi;Sofia Johansson;Dirk Stach;Martin Corcoran

  • Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells

    Pedro de Souza Rocha Simonini;Pedro de Souza Rocha Simonini;Achim Breiling;Nibedita Gupta;Mahdi Malekpour

  • A Dnmt2-like protein mediates DNA methylation in Drosophila.

    Natascha Kunert;Joachim Marhold;Jonas Stanke;Dirk Stach

  • Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila

    Frank Lyko;Bernard H. Ramsahoye;Helena Kashevsky;Matthew Tudor

Frequent Co-Authors

Mark Helm
Mark Helm Johannes Gutenberg University of Mainz
Hanno Glimm
Hanno Glimm TU Dresden
Manfred Wiessler
Manfred Wiessler German Cancer Research Center
José L. Medina-Franco
José L. Medina-Franco National Autonomous University of Mexico
Ulrich Germing
Ulrich Germing Heinrich Heine University Düsseldorf
Yehudit Bergman
Yehudit Bergman Hebrew University of Jerusalem
Eric A. Miska
Eric A. Miska University of Cambridge
Ryszard Maleszka
Ryszard Maleszka Australian National University
Albert Jeltsch
Albert Jeltsch University of Stuttgart

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