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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Genetics

D-Index
116
Citations
56180
World Ranking
443
National Ranking
16

Biology and Biochemistry

D-Index
117
Citations
56860
World Ranking
715
National Ranking
17

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2013 - Fellow of the Royal Society of Canada Academy of Science

Overview

Moshe Szyf is a researcher affiliated with McGill University in Canada, specializing primarily in biochemistry, genetics, and molecular biology, with significant contributions also in the field of medicine. Their academic work spans key subfields such as molecular biology, pediatrics, perinatology and child health, physiology, genetics, and cancer research.

Their research topics focus predominantly on epigenetics and DNA methylation, including DNA demethylation mechanisms and related gene regulation. Additional areas of investigation include birth, development, and health, CRISPR and genetic engineering, cancer-related gene regulation, RNA modifications in cancer, diet and metabolism studies, and genetics associated with neurodevelopmental disorders.

Szyf has published extensively with multiple papers appearing in respected journals. Selected recent publications include:

  • "Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial" (2021) in Aging
  • "Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9" (2021) in Nature Communications
  • "Building knowledge, optimising physical and mental health and setting up healthier life trajectories in South African women (Bukhali): a preconception randomised control trial part of the Healthy Life Trajectories Initiative (HeLTI)" (2022) in BMJ Open
  • "DNA methylation signatures of Prostate Cancer in peripheral T-cells" (2020) in BMC Cancer
  • "[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease" (2022) in Nature Communications

The primary venues for their work include:

  • Aging
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Scientific Reports
  • Oncologia i radiologia Kazakhstana

Frequent collaborators in their research comprise David Cheishvili, Shafaat A. Rabbani, Daniel M. Sapozhnikov, Ani Arakelian, and Niaz Mahmood.

In recognition of their contributions to science, they were elected Fellow of the Royal Society of Canada in 2013 for the Academy of Science.

Best Publications

  • Epigenetic programming by maternal behavior.

    Ian C G Weaver;Nadia Cervoni;Frances A Champagne;Ana C D'Alessio

  • Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

    Patrick O McGowan;Aya Sasaki;Aya Sasaki;Ana C D'Alessio;Sergiy Dymov

  • Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.

    Michael J. Meaney;Moshe Szyf

  • Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life

    Ian C. G. Weaver;Frances A. Champagne;Shelley E. Brown;Sergiy Dymov

  • Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood

    Ian C. G. Weaver;Michael J. Meaney;Moshe Szyf

  • Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.

    Philip Lawrence De Jager;Gyan Srivastava;Katie Lunnon;Jeremy Burgess

  • A mammalian protein with specific demethylase activity for mCpG DNA

    Sanjoy K. Bhattacharya;Shyam Ramchandani;Nadia Cervoni;Moshe Szyf

  • Maternal Care Associated with Methylation of the Estrogen Receptor-α1b Promoter and Estrogen Receptor-α Expression in the Medial Preoptic Area of Female Offspring

    Frances A. Champagne;Ian C. G. Weaver;Josie Diorio;Sergiy Dymov

  • Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health.

    Michael J. Meaney;Moshe Szyf;Jonathan R. Seckl

  • Maternal care as a model for experience-dependent chromatin plasticity?

    Michael J. Meaney;Moshe Szyf

  • Child health, developmental plasticity, and epigenetic programming.

    Z. Hochberg;Robert Feil;M. Constancia;M. Fraga

  • The social environment and the epigenome

    Moshe Szyf;Patrick McGowan;Michael J. Meaney

  • The Transcription Factor Nerve Growth Factor-Inducible Protein a Mediates Epigenetic Programming: Altering Epigenetic Marks by Immediate-Early Genes

    Ian C. G. Weaver;Ana C. D'Alessio;Shelley E. Brown;Ian C. Hellstrom

  • Associations with early-life socio-economic position in adult DNA methylation

    Nada Borghol;Matthew Suderman;Wendy L McArdle;Ariane Racine

  • Genome-wide Epigenetic Regulation by Early-Life Trauma

    Benoit Labonté;Matt Suderman;Gilles Maussion;Luis Navaro

  • Epigenetic Programming of Stress Responses through Variations in Maternal Care

    Eric W. Fish;Dara Shahrokh;Rose Bagot;Christian Caldji

  • Valproate induces replication-independent active DNA demethylation.

    Nancy Detich;Veronica Bovenzi;Moshe Szyf

  • Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites.

    Ian C.G. Weaver;Josie Diorio;Jonathan R. Seckl;Moshe Szyf

  • Epigenetics, DNA Methylation, and Chromatin Modifying Drugs

    Moshe Szyf

  • Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

    Gyan Srivastava;Katie Lunnon;Jeremy Burgess;Lei Yu

Frequent Co-Authors

Matthew Suderman
Matthew Suderman University of Bristol
Linda Booij
Linda Booij Concordia University
Richard E. Tremblay
Richard E. Tremblay University of Montreal
Michael J. Meaney
Michael J. Meaney McGill University
Stephen G. Matthews
Stephen G. Matthews University of Toronto
Gustavo Turecki
Gustavo Turecki Douglas Mental Health University Institute
A. Claudio Cuello
A. Claudio Cuello McGill University
Frank Vitaro
Frank Vitaro University of Montreal
Suzanne King
Suzanne King McGill University
Asher Ornoy
Asher Ornoy Hebrew University of Jerusalem

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