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D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
16732
World Ranking
7041
National Ranking
3239

Overview

Dennis R. Grayson is affiliated with the University of Illinois at Chicago in the United States. Their research primarily focuses on the intersection of molecular biology, genetics, neuroscience, and medicine, with a strong emphasis on epigenetics and neurobiological mechanisms underlying neurodevelopmental and neuropsychiatric disorders.

Their work spans several specialized subfields, including molecular biology, genetics, neurology, biological psychiatry, and cellular and molecular neuroscience. Main topics researched include epigenetics and DNA methylation, genetics related to neurodevelopmental disorders, neuroinflammation and neurodegeneration mechanisms, tryptophan metabolism and brain disorders, neuroscience and neuropharmacology, autism spectrum disorder, and stress responses involving cortisol.

Recent significant papers authored or co-authored by Grayson include:

  • Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure, 2021, published in Translational Psychiatry
  • Methylation and expression of glucocorticoid receptor exon-1 variants and FKBP5 in teenage suicide-completers, 2023, published in Translational Psychiatry
  • Epigenetic Regulation of GABAergic Neurotransmission and Neurosteroid Biosynthesis in Alcohol Use Disorder, 2020, published in The International Journal of Neuropsychopharmacology
  • Unraveling the epigenomic and transcriptomic interplay during alcohol-induced anxiolysis, 2022, published in Molecular Psychiatry
  • Concordance of Immune-Related Markers in Lymphocytes and Prefrontal Cortex in Schizophrenia, 2021, published in Schizophrenia Bulletin Open

Grayson collaborates frequently with other researchers in their field. Notable co-authors with whom they have multiple publications include:

  • Alessandro Guidotti
  • Jacob Peedicayil
  • Subhash C. Pandey
  • Eleonora Gatta
  • Jenny Drnevich

Their research is frequently published in journals such as Translational Psychiatry, Alcohol, Clinical Lymphoma Myeloma & Leukemia, The International Journal of Neuropsychopharmacology, and Molecular Psychiatry, reflecting a range of interests from molecular neuroscience to clinical implications of psychiatric disorders.

Best Publications

  • Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: A postmortem brain study

    Alessandro Guidotti;James Auta;John M. Davis;Valeria DiGiorgi Gerevini

  • Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.

    R. H. Costa;Dennis R. Grayson;J. E. Darnell

  • Reelin promoter hypermethylation in schizophrenia.

    Dennis R. Grayson;Xiaomei Jia;Ying Chen;Rajiv P. Sharma

  • Altering the course of schizophrenia: progress and perspectives

    Mark J. Millan;Annie Andrieux;George Bartzokis;Kristin Cadenhead

  • An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability

    L. Tremolizzo;G. Carboni;W. B. Ruzicka;C. P. Mitchell

  • DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains.

    M. Veldic;H. J. Caruncho;W. S. Liu;J. Davis

  • Developmental and mature expression of full-length and truncated TrkB receptors in the rat forebrain.

    Robert H. Fryer;David R. Kaplan;Stuart C. Feinstein;Monte J. Radeke

  • GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon

    Alessandro Guidotti;James Auta;John M. Davis;Erbo Dong

  • Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation

    E. Dong;M. Nelson;D. R. Grayson;E. Costa

  • On the epigenetic regulation of the human reelin promoter

    Ying Chen;Rajiv P. Sharma;Robert H. Costa;Erminio Costa

  • The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

    Dennis R Grayson;Alessandro Guidotti

  • Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice.

    Lucio Tremolizzo;Mohemed Salim Doueiri;Erbo Dong;Dennis R. Grayson

  • Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice.

    Francesco Matrisciano;Patricia Tueting;Ishani Dalal;Bashkim Kadriu

  • Chronic ethanol consumption differentially alters the expression of gamma-aminobutyric acidA receptor subunit mRNAs in rat cerebral cortex: competitive, quantitative reverse transcriptase-polymerase chain reaction analysis.

    L L Devaud;F D Smith;D R Grayson;A L Morrow

  • Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection.

    W B Ruzicka;A Zhubi;M Veldic;D R Grayson

  • Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters

    E. Dong;A. Guidotti;D. R. Grayson;E. Costa

  • Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia

    E. Dong;R. C. Agis-Balboa;M. V. Simonini;D. R. Grayson

  • A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes

    Robert H. Costa;Dennis R. Grayson;Kleanthis G. Xanthopoulos;James E. Darnell

  • Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability.

    Erminio Costa;John Davis;Dennis R. Grayson;Alessandro Guidotti

  • Reelin gene alleles and susceptibility to autism spectrum disorders

    H Zhang;X Liu;C Zhang;E Mundo;E Mundo

Frequent Co-Authors

Alessandro Guidotti
Alessandro Guidotti University of Illinois at Chicago
John M. Davis
John M. Davis University of Illinois at Chicago
Robert H. Costa
Robert H. Costa University of Illinois at Chicago
James E. Darnell
James E. Darnell Rockefeller University
Graziano Pinna
Graziano Pinna University of Illinois at Chicago
Stefano Vicini
Stefano Vicini Georgetown University Medical Center
David M. Armstrong
David M. Armstrong National Institutes of Health
Henry Sershen
Henry Sershen New York University
Milos D. Ikonomovic
Milos D. Ikonomovic University of Pittsburgh
Edwin H. Cook
Edwin H. Cook University of Illinois at Chicago

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