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Neuroscience

D-Index
92
Citations
28670
World Ranking
1032
National Ranking
545

Overview

Schahram Akbarian is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, contributing extensively to the understanding of molecular biology, genetics, and neurology.

The scientist has published a significant number of works across various subfields, including molecular biology, genetics, neurology, cancer research, and cellular and molecular neuroscience. Their research topics cover a range of areas such as epigenetics and DNA methylation, genomics and chromatin dynamics, neuroinflammation and neurodegeneration mechanisms, genomic variations and chromosomal abnormalities, single-cell and spatial transcriptomics, RNA modifications and cancer, as well as RNA research and splicing.

Notable recent papers authored or co-authored by Akbarian include:

  • Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions (2020, Scientific Data)
  • A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles (2020, Nature Neuroscience)
  • A prefrontal-paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice (2020, Nature Neuroscience)
  • Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior (2020, Nature Communications)
  • The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing (2021, Nature Neuroscience)

Schahram Akbarian frequently collaborates with other researchers in the field. Key frequent co-authors include Kristen Brennand, Daniel H. Geschwind, Raquel E. Gur, Joel Gelernter, and Anissa Abi-Dargham.

Their research has been published often in several prominent venues, including:

  • Biological Psychiatry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Psychiatry
  • Nature Communications
  • Science

Best Publications

  • Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

    Richard Z. Chen;Schahram Akbarian;Schahram Akbarian;Matthew Tudor;Rudolf Jaenisch

  • Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.

    Schahram Akbarian;James J. Kim;Steven G. Potkin;Jennifer O. Hagman

  • Comprehensive functional genomic resource and integrative model for the human brain

    Daifeng Wang;Daifeng Wang;Shuang Liu;Jonathan Warrell;Hyejung Won

  • Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development

    Schahram Akbarian;William E. Bunney;Steven G. Potkin;Sharon B. Wigal

  • Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development.

    Schahram Akbarian;Angel Viñuela;James J. Kim;Steven G. Potkin

  • Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse

    Frederick Albert Schroeder;Cong L. Lin;Wim E. Crusio;Schahram Akbarian

  • Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics

    S Akbarian;NJ Sucher;D Bradley;A Tafazzoli

  • Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain

    NJ Sucher;S Akbarian;CL Chi;CL Leclerc

  • Maldistribution of Interstitial Neurons in Prefrontal White Matter of the Brains of Schizophrenic Patients

    Akbarian S;Kim Jj;Potkin Sg;Hetrick Wp

  • DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons

    Kimberly D. Siegmund;Caroline M. Connor;Mihaela Campan;Tiffany I. Long

  • Epigenetic mechanisms in neurological disease

    Mira Jakovcevski;Schahram Akbarian

  • Prefrontal Cortex and Social Cognition in Mouse and Man.

    Lucy K. Bicks;Hiroyuki Koike;Schahram Akbarian;Hirofumi Morishita

  • The PsychENCODE project

    Schahram Akbarian;Chunyu Liu;James A Knowles;Flora M Vaccarino

  • Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders

    Schahram Akbarian;Hsien-Sung Huang

  • Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain

    Matthew Tudor;Schahram Akbarian;Richard Z. Chen;Rudolf Jaenisch

  • Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters.

    Hsien-Sung Huang;Anouch Matevossian;Catheryne Whittle;Se Young Kim

  • Epigenetic Basis of Mental Illness

    Eric J. Nestler;Catherine J. Peña;Marija Kundakovic;Amanda Mitchell

  • A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex

    Nikolaos Mellios;Hsien-Sung Huang;Anastasia P. Grigorenko;Evgeny I. Rogaev

  • Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions.

    S K Sieberts;T M Perumal;M M Carrasquillo;M Allen

  • Critical Role of Histone Turnover in Neuronal Transcription and Plasticity.

    Ian Maze;Ian Maze;Wendy Wenderski;Kyung Min Noh;Rosemary C. Bagot

  • Molecular Determinants of Dysregulated GABAergic Gene Expression in the Prefrontal Cortex of Subjects with Schizophrenia

    Nikolaos Mellios;Hsien-Sung Huang;Stephen P. Baker;Marzena Galdzicka

Frequent Co-Authors

Zhiping Weng
Zhiping Weng University of Massachusetts Chan Medical School
Eric J. Nestler
Eric J. Nestler Icahn School of Medicine at Mount Sinai
Pamela Sklar
Pamela Sklar Icahn School of Medicine at Mount Sinai
Edward G. Jones
Edward G. Jones University of California, Davis
Vahram Haroutunian
Vahram Haroutunian Icahn School of Medicine at Mount Sinai
Evgeny I. Rogaev
Evgeny I. Rogaev University of Massachusetts Chan Medical School
Jiang-Fan Chen
Jiang-Fan Chen Boston University
Philipp Khaitovich
Philipp Khaitovich Skolkovo Institute of Science and Technology
Barbara K. Lipska
Barbara K. Lipska National Institutes of Health
Joseph G. Gleeson
Joseph G. Gleeson University of California, San Diego

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