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Neuroscience

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124
Citations
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World Ranking
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National Ranking
201

Medicine

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Citations
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National Ranking
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Overview

Vahram Haroutunian is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research spans multiple areas in biochemistry, genetics, molecular biology, and medicine with a primary focus on neurodegenerative disorders, particularly Alzheimer's disease.

Their scientific work extensively covers topics including:

  • Alzheimer's disease research and treatments
  • Bioinformatics and genomic networks
  • Neuroinflammation and neurodegeneration mechanisms
  • Epigenetics and DNA methylation
  • Genomics and chromatin dynamics
  • Dementia and cognitive impairment research
  • Single-cell and spatial transcriptomics

Their publications appear predominantly in high-impact journals and frequent venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer's & Dementia
  • Nature Communications
  • Nature Neuroscience
  • Nature Genetics

Notable recent papers include:

  • Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation (2020, Nature Medicine)
  • Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression (2020, Neuron)
  • Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level (2022, Nature Neuroscience)
  • Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions (2020, Scientific Data)
  • FSH blockade improves cognition in mice with Alzheimer's disease (2022, Nature)

Frequent coauthors of the scientist include:

  • Panos Roussos
  • John F. Fullard
  • Jaroslav Bendl
  • Gabriel E. Hoffman
  • Kiran Girdhar

In addition to their broad expertise in biochemistry, genetics, and molecular biology, the scientist also contributes to subfields such as molecular biology, physiology, genetics, neurology, and psychiatry and mental health.

With a substantial number of publications in the intersection of molecular mechanisms and neurodegenerative diseases, the scientist's work focuses on understanding the biological underpinnings of Alzheimer's disease, exploring proteomic and genomic approaches to elucidate disease progression and cognitive impairment.

Best Publications

  • Biological insights from 108 schizophrenia-associated genetic loci

    Stephan Ripke;Stephan Ripke;Benjamin M. Neale;Benjamin M. Neale;Aiden Corvin;James T. R. Walters

  • Mapping genomic loci implicates genes and synaptic biology in schizophrenia

    Unknown

  • Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

    Peter T Nelson;Irina Alafuzoff;Eileen H Bigio;Constantin Bouras

  • Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

    Jan Näslund;Vahram Haroutunian;Richard Mohs;Kenneth L. Davis

  • Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

    Bjarni J. Vilhjálmsson;Jian Yang;Hilary K. Finucane;Alexander Gusev

  • Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia.

    Yaron Hakak;John R. Walker;Cheng Li;Wing Hung Wong

  • Intraneuronal Aβ42 Accumulation in Human Brain

    Gunnar K. Gouras;Gunnar K. Gouras;Julia Tsai;Jan Naslund;Bruno Vincent

  • Gene expression elucidates functional impact of polygenic risk for schizophrenia

    Menachem Fromer;Panos Roussos;Solveig K. Sieberts;Jessica S. Johnson

  • Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

    Sang Won Min;Seo Hyun Cho;Yungui Zhou;Sebastian Schroeder

  • Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

    Christian R Marshall;Daniel P Howrigan;Daniel P Howrigan;Daniele Merico;Bhooma Thiruvahindrapuram

  • White matter changes in schizophrenia: evidence for myelin-related dysfunction.

    Kenneth L. Davis;Daniel G. Stewart;Joseph I. Friedman;Monte Buchsbaum

  • Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

    Erik C.B. Johnson;Eric B. Dammer;Duc M. Duong;Lingyan Ping

  • Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits.

    Linda M. Bierer;Vahram Haroutunian;Steve Gabriel;Peter J. Knott

  • Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

    Douglas M. Ruderfer;Stephan Ripke;Stephan Ripke;Stephan Ripke;Andrew McQuillin;James Boocock

  • Mitochondrial abnormalities in Alzheimer brain: mechanistic implications.

    Parvesh Bubber;Vahram Haroutunian;Gene Fisch;John P. Blass

  • Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level

    Unknown

  • Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.

    Benjamin Readhead;Jean Vianney Haure-Mirande;Cory C. Funk;Matthew A. Richards

  • Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

    Alexander Gusev;S. Hong Lee;Gosia Trynka;Hilary Finucane

  • Cholinergic markers in elderly patients with early signs of Alzheimer disease.

    Kenneth L. Davis;Richard C. Mohs;Deborah Marin;Dushyant P. Purohit

  • Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

    Katie Lunnon;Rebecca Smith;Eilis Hannon;Philip L De Jager

  • Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia.

    Patrick R Hof;Vahram Haroutunian;Vahram Haroutunian;Victor L Friedrich;William Byne;William Byne

  • Erratum to Acetylation of tau inhibits its degradation and contributes to tauopathy

    Sang Won Min;Seo Hyun Cho;Yungui Zhou;Sebastian Schroeder

Frequent Co-Authors

Kenneth L. Davis
Kenneth L. Davis Icahn School of Medicine at Mount Sinai
James H. Meador-Woodruff
James H. Meador-Woodruff University of Alabama at Birmingham
Joseph D. Buxbaum
Joseph D. Buxbaum Icahn School of Medicine at Mount Sinai
Panos Roussos
Panos Roussos Icahn School of Medicine at Mount Sinai
Daniel P. Perl
Daniel P. Perl Uniformed Services University of the Health Sciences
Jeremy M. Silverman
Jeremy M. Silverman Icahn School of Medicine at Mount Sinai
James Schmeidler
James Schmeidler Icahn School of Medicine at Mount Sinai
Robert E. McCullumsmith
Robert E. McCullumsmith University of Cincinnati
Tune H. Pers
Tune H. Pers University of Copenhagen
Patrick F. Sullivan
Patrick F. Sullivan University of North Carolina at Chapel Hill

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