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Molecular Biology
USA
2026
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Genetics and Molecular Biology
USA
2024

D-Index & Metrics

Molecular Biology

D-Index
154
Citations
106258
World Ranking
74
National Ranking
47

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2002 - US President's National Medal of Science "For his seminal scientific discoveries related to gene expression in animal cells, including pathways of RNA processing and signal transduction from the cell surface to genes in the nucleus, and for his contributions as a scientific educator", Presented by President George W. Bush in a White House East Room ceremony on November 6, 2003.
  • 1998 - E.B. Wilson Medal, American Society for Cell Biology
  • 1996 - Fellow of the Royal Society, United Kingdom
  • 1991 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1986 - Canada Gairdner International Award
  • 1973 - Fellow of the American Academy of Arts and Sciences
  • 1963 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

James E. Darnell is affiliated with Rockefeller University in the United States. Their research spans multiple fields, including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. The main subfields of study in their work include Immunology, Molecular Biology, Oncology, and Epidemiology.

The scientific topics covered by Darnell's research focus on Cytokine Signaling Pathways and Interactions, interferon and immune responses, Mycobacterium research and diagnosis, RNA Interference and Gene Delivery, Immunotherapy and Immune Responses, and Genomics and Chromatin Dynamics.

Darnell has published in notable venues including Cell and Molecular Therapy Oncology. Their recent publications include:

  • "The JAK-STAT pathway at 30: Much learned, much more to do" (2022, Cell)
  • "Allele-specific depletion of GNAQQ209L via siRNA or an rAAV2-shRNA vector induces selective toxicity in GNAQQ209L uveal melanoma cells" (2025, Molecular Therapy Oncology)

Frequent coauthors contributing to these works are:

  • Rachael L. Philips
  • Yuxin Wang
  • HyeonJoo Cheon
  • Yuka Kanno
  • Massimo Gadina

Darnell's research career has been recognized with several awards and honors, including the US President's National Medal of Science awarded in 2002 for seminal discoveries related to gene expression and signal transduction pathways. Additional distinctions include the E.B. Wilson Medal from the American Society for Cell Biology (1998), Fellowship in the Royal Society, United Kingdom (1996), Fellowship of the American Association for the Advancement of Science (AAAS) in 1991 and again in 1963, the Canada Gairdner International Award (1986), and Fellowship of the American Academy of Arts and Sciences (1973).

Best Publications

  • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

    James E. Darnell;Ian M. Kerr;George Stark Stark

  • STATs and Gene Regulation

    Jr. James E. Darnell

  • STATs: transcriptional control and biological impact

    David E. Levy;J. E. Darnell

  • Stat3 as an Oncogene

    Jacqueline F Bromberg;Melissa H Wrzeszczynska;Geeta Devgan;Yanxiang Zhao

  • Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

    Zhong Zhong;Zilong Wen;James E. Darnell

  • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.

    Zilong Wen;Zhong Zhong;James E Darnell

  • The JAK-STAT pathway at twenty.

    George R. Stark;James E. Darnell

  • Transcription factors as targets for cancer therapy

    James E. Darnell

  • The role of STATs in transcriptional control and their impact on cellular function.

    Jacqueline Bromberg;James E Darnell

  • Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

    Christian Vaisse;Jeffrey L Halaas;Curt M. Horvath;James E. Darnell

  • Sedimentation characteristics of rapidly labelled RNA from HeLa cells

    Klaus Scherrer;J.E. Darnell

  • Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

    Neil Stahl;Thomas J. Farruggella;Teri G. Boulton;Zhong Zhong

  • Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

    F M Sladek;W M Zhong;E Lai;J E Darnell

  • Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.

    Chris Schindler;Ke Shuai;Vincent R. Prezioso;James E. Darnell

  • A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma

    Ke Shuai;George R. Stark;Ian M. Kerr;James E. Darnell

  • Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein

    Ke Shuai;Chris Schindler;Vincent R. Prezioso;James E. Darnell

  • Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.

    Ke Shuai;Curt M. Horvath;Linda H.Tsai Huang;Sajjad A. Qureshi

  • A common nuclear signal transduction pathway activated by growth factor and cytokine receptors.

    Henry B. Sadowski;Ke Shuai;James E. Darnell;Michael Z. Gilman

  • Signal transduction and the control of gene expression.

    Ali H. Brivanlou;James E. Darnell

  • ErratumStat3 as an Oncogene

    Jacqueline F Bromberg;Melissa H Wrzeszczynska;Geeta Devgan;Yanxiang Zhao

Frequent Co-Authors

Zilong Wen
Zilong Wen Hong Kong University of Science and Technology
David E. Levy
David E. Levy New York University
Curt M. Horvath
Curt M. Horvath Northwestern University
John Kuriyan
John Kuriyan Vanderbilt University
Xin Yuan Fu
Xin Yuan Fu National University of Singapore
Ke Shuai
Ke Shuai University of California, Los Angeles
Frances M. Sladek
Frances M. Sladek University of California, Riverside
Thomas Decker
Thomas Decker University of Vienna
Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
Nigel W. Fraser
Nigel W. Fraser University of Pennsylvania

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