World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
15519
World Ranking
15402
National Ranking
444

Overview

Zilong Wen is affiliated with the Hong Kong University of Science and Technology in China. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with a focus also on medicine. The scientist's work extensively covers subfields such as cell biology, molecular biology, immunology, genetics, and neurology.

Wen's research interests prominently include zebrafish biomedical research applications, immune cells in cancer, neuroinflammation and neurodegeneration mechanisms, genetic and phenotypic traits in livestock, genetic mapping and diversity in plants and animals, single-cell and spatial transcriptomics, and animal nutrition and physiology.

Their publication record features multiple frequent venues reflecting diverse research topics, including:

  • eLife
  • Development
  • Cell Reports
  • Science Advances
  • Cell Death and Disease

Frequent coauthors in their works include Jin Xu, Shizheng Zhao, Tao Yu, Zhibin Huang, and Shachuan Feng, indicating collaborative efforts across multiple research projects.

Several recent papers illustrate the scope of Wen's research contributions:

  • "Two phenotypically and functionally distinct microglial populations in adult zebrafish" (2020, Science Advances)
  • "Cross-organ single-cell transcriptome profiling reveals macrophage and dendritic cell heterogeneity in zebrafish" (2023, Cell Reports)
  • "Tumor-associated macrophages promote cholangiocarcinoma progression via exosomal Circ_0020256" (2022, Cell Death and Disease)
  • "De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation" (2021, Circulation Research)
  • "In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy" (2020, eLife)

Best Publications

  • Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

    Zhong Zhong;Zilong Wen;James E. Darnell

  • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.

    Zilong Wen;Zhong Zhong;James E Darnell

  • A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

    Curt M. Horvath;Zilong Wen;James E. Darnell

  • Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma

    Jacqueline F. Bromberg;Curt M. Horvath;Zilong Wen;Robert D. Schreiber

  • Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo.

    Ying Li;Xu-fei Du;Chang-sheng Liu;Zi-long Wen

  • Stat3 and Stat4: members of the family of signal transducers and activators of transcription

    Zhong Zhong;Zilong Wen;James E. Darnell

  • Mapping of Stat3 Serine Phosphorylation to a Single Residue (727) and Evidence That Serine Phosphorylation Has No Influence on DNA Binding of Stat1 and Stat3

    Zilong Wen;James E. Darnell

  • Live imaging reveals differing roles of macrophages and neutrophils during Zebrafish tail fin regeneration

    Li Li;Li Li;Bo Yan;Yu-Qian Shi;Wen-Qing Zhang

  • Distribution of the mammalian Stat gene family in mouse chromosomes

    Neal G. Copeland;Debra J. Gilbert;Chris Schindler;Chris Schindler;Zhong Zhong

  • Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice

    Shen Yon Toh;Shen Yon Toh;Shen Yon Toh;Jingyi Gong;Guoli Du;John Zhong Li;John Zhong Li

  • 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis.

    Jane Lo;Sorcheng Lee;Min Xu;Feng Liu

  • STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase

    Teri G. Boulton;Zhong Zhong;Zilong Wen;James E. Darnell

  • Loss of function of def selectively up-regulates Δ113p53 expression to arrest expansion growth of digestive organs in zebrafish

    Jun Chen;Hua Ruan;Sok Meng Ng;Chuan Gao

  • Cideb Regulates Diet-Induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation

    John Zhong Li;Jing Ye;Bofu Xue;Jingzhong Qi

  • Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase

    X. Zhu;Z. Wen;Liang Zhong Xu;J. E. Darnell

  • Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver.

    Susan Ruff-Jamison;Zhong Zhong;Zilong Wen;Katherine Chen

  • Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes.

    Mei Huang;Feng Qian;Yuanyu Hu;Chengeng Ang

  • Migratory path of definitive hematopoietic stem/progenitor cells during zebrafish development

    Hao Jin;Jin Xu;Zilong Wen

  • Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish.

    Jin Xu;Lu Zhu;Sicong He;Yi Wu

  • Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis.

    Li Li;Hao Jin;Jin Xu;Yuqian Shi

Frequent Co-Authors

James E. Darnell
James E. Darnell Rockefeller University
Jinrong Peng
Jinrong Peng Zhejiang University
Mingjie Zhang
Mingjie Zhang Hong Kong University of Science and Technology
Motomi Osato
Motomi Osato National University of Singapore
Xin Yuan Fu
Xin Yuan Fu National University of Singapore
Curt M. Horvath
Curt M. Horvath Northwestern University
Yoshiaki Ito
Yoshiaki Ito National University of Singapore
John R. Murphy
John R. Murphy Johns Hopkins University
Robert Geisler
Robert Geisler Max Planck Society
Ben Zhong Tang
Ben Zhong Tang Chinese University of Hong Kong, Shenzhen

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