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Microbiology

D-Index
75
Citations
24613
World Ranking
1481
National Ranking
648

Overview

Curt M. Horvath is affiliated with Northwestern University in the United States. Their research primarily spans the fields of medicine and immunology and microbiology. Within these broad areas, Horvath has contributed extensively to subfields including immunology, infectious diseases, oncology, epidemiology, and molecular biology.

The core topics addressed in Horvath's work focus on immune system function and responses. These include interferon and immune responses, COVID-19 clinical research studies, SARS-CoV-2 and COVID-19 research, cytokine signaling pathways and interactions, immune cell function and interaction, respiratory viral infections research, as well as Mycobacterium research and diagnosis.

Horvath's noteworthy recent publications include:

  • Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia, 2021, Nature
  • The JAK-STAT pathway at 30: Much learned, much more to do, 2022, Cell
  • Immune regulator LGP2 targets Ubc13/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-κB activation, 2021, Cell Reports
  • Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors, 2022, Molecular Cancer Research
  • Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia, 2024, Nature Immunology

These publications appear in several journals including bioRxiv (Cold Spring Harbor Laboratory), Nature, Cell, Cell Reports, and Molecular Cancer Research. Horvath has contributed multiple papers in these venues with the highest concentration in bioRxiv and notable works in Nature and Cell.

Frequent coauthors collaborating with Horvath include:

  • Estefany Rios-Guzman
  • Hiam Abdala-Valencia
  • Rogan A. Grant
  • Luisa Morales-Nebreda
  • Nikolay S. Markov

Best Publications

  • A Road Map for Those Who Don't Know JAK-STAT

    David S. Aaronson;Curt M. Horvath

  • Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

    Christian Vaisse;Jeffrey L Halaas;Curt M. Horvath;James E. Darnell

  • Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.

    Ke Shuai;Curt M. Horvath;Linda H.Tsai Huang;Sajjad A. Qureshi

  • Stat3 Activation Is Required for Cellular Transformation by v-src

    Jacqueline F. Bromberg;Curt M. Horvath;Daniel Besser;Wyndham W. Lathem

  • Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein

    Julie Talon;Curt M. Horvath;Rosalind Polley;Christopher F. Basler

  • The JAK-STAT pathway at 30: Much learned, much more to do

    Unknown

  • A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

    Curt M. Horvath;Zilong Wen;James E. Darnell

  • Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma

    Jacqueline F. Bromberg;Curt M. Horvath;Zilong Wen;Robert D. Schreiber

  • Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia.

    Rogan A Grant;Luisa Morales-Nebreda;Nikolay S Markov;Suchitra Swaminathan

  • STAT proteins and transcriptional responses to extracellular signals

    Curt M Horvath

  • Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

    Aseem Kumar;Mairead Commane;Thomas W. Flickinger;Curt M. Horvath;Curt M. Horvath

  • Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

    Jue J. Zhang;Uwe Vinkemeier;Wei Gu;Debabrata Chakravarti

  • TYK2 and JAK2 Are Substrates of Protein-tyrosine Phosphatase 1B

    Michael P. Myers;Jannik N. Andersen;Alan Cheng;Michel L. Tremblay

  • DNA binding specificity of different STAT proteins: Comparison of in vitro specificity with natural target sites

    Georg B. Ehret;Patrick Reichenbach;Ulrike Schindler;Curt M. Horvath

  • The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

    Constantin S Friedman;Marie Anne O'Donnell;Diana Legarda‐Addison;Aylwin Ng

  • RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2.

    Akihiko Komuro;Curt M. Horvath;Curt M. Horvath

  • STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.

    Heidi Palosaari;Jean Patrick Parisien;Jason J. Rodriguez;Christina M. Ulane

  • Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1

    Inna Nusinzon;Curt M. Horvath

  • Nipah Virus V Protein Evades Alpha and Gamma Interferons by Preventing STAT1 and STAT2 Activation and Nuclear Accumulation

    Jason J. Rodriguez;Jean Patrick Parisien;Curt M. Horvath

  • Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway

    Nancy Au-Yeung;Roli Mandhana;Curt M Horvath

  • Cooperation between STAT3 and c-Jun Suppresses Fas Transcription

    Vladimir N Ivanov;Anindita Bhoumik;Mikhail Krasilnikov;Regina Raz

  • Interacting Regions in Stat3 and c-Jun That Participate in Cooperative Transcriptional Activation

    Xiaokui Zhang;Melissa H. Wrzeszczynska;Curt M. Horvath;James E. Darnell

  • The state of the STATs: recent developments in the study of signal transduction to the nucleus

    Curt M Horvath;James E Darnell

Frequent Co-Authors

James E. Darnell
James E. Darnell Rockefeller University
Robert A. Lamb
Robert A. Lamb Northwestern University
Glen N. Barber
Glen N. Barber University of Miami
Zilong Wen
Zilong Wen Hong Kong University of Science and Technology
John F. Marko
John F. Marko Northwestern University
Sua Myong
Sua Myong Johns Hopkins University
Christopher F. Basler
Christopher F. Basler University of Georgia
Ian M. Kerr
Ian M. Kerr The Honourable Society of Lincoln's Inn
Adolfo García-Sastre
Adolfo García-Sastre Icahn School of Medicine at Mount Sinai
David E. Levy
David E. Levy New York University

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