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D-Index
88
Citations
27688
World Ranking
1209
National Ranking
105

Overview

Holger Lerche is affiliated with the University of Tübingen in Germany and has a focused research profile primarily within the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Their body of work includes numerous publications related to the genetic and molecular underpinnings of neurological disorders, particularly epilepsies.

The scientist's research spans several interconnected subfields such as Genetics, Molecular Biology, Psychiatry and Mental Health, Cellular and Molecular Neuroscience, and Cognitive Neuroscience. These areas reflect the multidisciplinary nature of their investigations into brain function and genetic influences on neurological conditions.

Holger Lerche's main topical contributions can be categorized into:

  • Epilepsy research and treatment
  • Ion channel regulation and function
  • Genomics and Rare Diseases
  • Genetics and Neurodevelopmental Disorders
  • Neuroscience and Neuropharmacology Research
  • Cardiac electrophysiology and arrhythmias
  • Neurological disorders and treatments

The scientist has authored or contributed to several papers of note, including:

  • Predicting functional effects of missense variants in voltage-gated sodium and calcium channels, 2020, Science Translational Medicine
  • Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress, 2022, Epilepsia
  • GAA-FGF14 ataxia (SCA27B): phenotypic profile, natural history progression and 4-aminopyridine treatment response, 2023, Brain
  • Biological concepts in human sodium channel epilepsies and their relevance in clinical practice, 2020, Epilepsia
  • Current practice in diagnostic genetic testing of the epilepsies, 2022, Epileptic Disorders

Holger Lerche regularly collaborates with several researchers in the field. Frequent co-authors include Ulrike B. S. Hedrich, Ingo Helbig, Roland Krause, Patrick May, and Sarah Weckhuysen.

The scientist's work appears consistently in peer-reviewed journals with a concentration in specialized venues such as bioRxiv (Cold Spring Harbor Laboratory), Brain, Epilepsia, Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, and EBioMedicine.

Best Publications

  • Analysis of shared heritability in common disorders of the brain

    Verneri Anttila;Verneri Anttila;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Hilary K. Finucane;Raymond K. Walters;Raymond K. Walters

  • Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): A retrospective study

    Philippe Ryvlin;Lina Nashef;Samden D Lhatoo;Lisa M Bateman

  • Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery.

    Blumcke I;Spreafico R;Haaker G;Coras R

  • 15q13.3 microdeletions increase risk of idiopathic generalized epilepsy

    Ingo Helbig;Heather C. Mefford;Andrew J. Sharp;Michel Guipponi

  • Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells.

    Andreas Hermann;Regina Gastl;Stefan Liebau;M. Oana Popa

  • Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders.

    Markus Wolff;Katrine M Johannesen;Ulrike B S Hedrich;Silvia Masnada

  • Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies

    Carolien G F De Kovel;Holger Trucks;Ingo Helbig;Heather C. Mefford

  • Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes

    Johannes R Lemke;Dennis Lal;Eva M Reinthaler;Isabelle Steiner

  • Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

    Bassel Abou-Khalil;Pauls Auce;Andreja Avbersek;Melanie Bahlo

  • Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

    Karsten Haug;Maike Warnstedt;Alexi K Alekov;Thomas Sander

  • Targeted next generation sequencing as a diagnostic tool in epileptic disorders

    Johannes R. Lemke;Erik Riesch;Tim Scheurenbrand;Max Schubach

  • GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak

    Yvonne G. Weber;Alexander Storch;Thomas V. Wuttke;Knut Brockmann

  • Paroxysmal exercise-induced dyskinesia and epilepsy is due to mutations in SLC2A1, encoding the glucose transporter GLUT1.

    Arvid Suls;Peter Dedeken;Karolien Goffin;Hilde Van Esch

  • A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy

    Mikko Muona;Samuel F. Berkovic;Leanne M. Dibbens;Karen L. Oliver

  • De novo loss-or gain-of-function mutations in KCNA2 cause epileptic encephalopathy

    Steffen Syrbe;Ulrike B.S. Hedrich;Erik Riesch;Tania Djémié

  • The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate.

    Thomas V. Wuttke;Guiscard Seebohm;Sigrid Bail;Snezana Maljevic

  • Early-onset absence epilepsy caused by mutations in the glucose transporter GLUT1.

    Arvid Suls;Saul A. Mullen;Yvonne G. Weber;Kristien Verhaert

  • Dominant‐negative effects of KCNQ2 mutations are associated with epileptic encephalopathy

    Gökce Orhan;Merle Bock;Dorien Schepers;Elena I. Ilina

  • Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies

    Richard Anney;A. Avbersek;D. Balding;L. Baum

  • Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

    Unknown

  • Erratum: De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies (American Journal of Human Genetics (2014) 95(4) (360–370)(S0002929714003838)(10.1016/j.ajhg.2014.08.013))

    Silke Appenzeller;Rudi Balling;Nina Barisic;Stéphanie Baulac

  • Paroxysmal exercise-induced dyskinesia and epilepsy due to mutations in SLC2A1, encoding the glucose transporter, Gluti

    David Cassiman;A Suls;P Dedeken;Karolien Goffin

Frequent Co-Authors

Yvonne G. Weber
Yvonne G. Weber University of Tübingen
Ingo Helbig
Ingo Helbig Children's Hospital of Philadelphia
Snezana Maljevic
Snezana Maljevic Florey Institute of Neuroscience and Mental Health
Rikke S. Møller
Rikke S. Møller University of Southern Denmark
Thomas Sander
Thomas Sander University of Cologne
Federico Zara
Federico Zara University of Genoa
Peter Nürnberg
Peter Nürnberg University of Cologne
Pasquale Striano
Pasquale Striano University of Genoa
Felix Rosenow
Felix Rosenow Goethe University Frankfurt
Ingrid E. Scheffer
Ingrid E. Scheffer University of Melbourne

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