His primary areas of investigation include Virology, Interferon, Virus, Hepatitis C virus and RIG-I. His studies deal with areas such as RNA and Immunology, Innate immune system, Immune system as well as Virology. His Interferon research is multidisciplinary, relying on both Transcription factor, Interferon regulatory factors, Protein kinase R, Signal transduction and Regulation of gene expression.
His study focuses on the intersection of Virus and fields such as TLR3 with connections in the field of Herpes simplex virus, TRIF and Vesicular stomatitis virus. His RIG-I research includes elements of Pathogen and MDA5. His research integrates issues of RNA virus and Cell biology in his study of RIG-I-like receptor.
Michael Gale spends much of his time researching Virology, Innate immune system, Virus, Immunology and Interferon. His Virology course of study focuses on RIG-I and MDA5. His Innate immune system research is multidisciplinary, incorporating perspectives in Acquired immune system, RNA virus and Signal transduction, Cell biology.
His Cell biology study combines topics in areas such as RNA and Inflammasome. His Virus research integrates issues from Regulation of gene expression and Transcription factor. In his research, EIF-2 kinase is intimately related to Protein kinase R, which falls under the overarching field of Interferon.
His main research concerns Virology, Innate immune system, Virus, Cell biology and Immunology. His work carried out in the field of Virology brings together such families of science as Antibody and Immune system, Immunity. Michael Gale has researched Innate immune system in several fields, including Interferon and Viral replication.
His study in Virus is interdisciplinary in nature, drawing from both ALVAC Vaccine and Coronavirus disease 2019. His Cell biology research is multidisciplinary, incorporating elements of Cell, RNA, DNA, Messenger RNA and Programmed cell death. His biological study spans a wide range of topics, including Microbiome and Disease.
Michael Gale focuses on Innate immune system, Cell biology, Virology, Antibody and Virus. Michael Gale interconnects Interferon, MDA5, Viral replication and Immunity in the investigation of issues within Innate immune system. His studies examine the connections between Interferon and genetics, as well as such issues in Inflammation, with regards to Disease.
His Cell biology research includes themes of RNA, Cell, IRF1 and Programmed cell death. His studies in Virology integrate themes in fields like T cell, Replicon and Immunogenicity. The concepts of his Virus study are interwoven with issues in DNA, DNA damage, Protein kinase A, Phosphorylation and Adenoviridae.
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Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity
Mitsutoshi Yoneyama;Mika Kikuchi;Kanae Matsumoto;Tadaatsu Imaizumi.
Journal of Immunology (2005)
Immune Signaling by RIG-I-like Receptors
Yueh Ming Loo;Michael Gale.
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
Kui Li;Eileen Foy;Josephine C. Ferreon;Mitsuyasu Nakamura.
Proceedings of the National Academy of Sciences of the United States of America (2005)
Viruses and interferon: a fight for supremacy
Michael G. Katze;Yupeng He;Michael Gale.
Nature Reviews Immunology (2002)
Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity
Yueh Ming Loo;Jamie Fornek;Nanette Crochet;Gagan Bajwa.
Journal of Virology (2008)
Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease
Eileen Foy;Kui Li;Chunfu Wang;Rhea Sumpter.
Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
Michael J. Gale;Marcus J. Korth;Norina M. Tang;Seng Lai Tan.
Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I
Rhea Sumpter;Yueh Ming Loo;Eileen Foy;Kui Li.
Journal of Virology (2005)
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.
Takeshi Saito;Reiko Hirai;Yueh Ming Loo;David Owen.
Proceedings of the National Academy of Sciences of the United States of America (2007)
Evasion of intracellular host defence by hepatitis C virus
Michael Gale;Eileen M. Foy.
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