World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
56
Citations
11924
World Ranking
3693
National Ranking
1451

Research.com Recognitions

  • 1950 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Stephen J. Polyak is affiliated with the University of Washington in the United States. Their research primarily focuses on the field of Medicine, with notable contributions across several subfields including Infectious Diseases, Epidemiology, Molecular Biology, Emergency Medicine, and Pharmacology.

The main topics covered in their work include:

  • SARS-CoV-2 and COVID-19 Research
  • HIV-related health complications and treatments
  • Viral gastroenteritis research and epidemiology
  • HIV Research and Treatment
  • COVID-19 Clinical Research Studies
  • Viral Infections and Immunology Research
  • Protein Degradation and Inhibitors

Recent publications by Stephen J. Polyak include:

  • "Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants," 2021, Journal of Ethnopharmacology
  • "Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma," 2020, Gut
  • "CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice," 2020, Molecular Therapy - Methods & Clinical Development
  • "Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses," 2021, mBio
  • "Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2," 2022, Microbiology Spectrum

Frequent co-authors who have collaborated on multiple publications with Stephen J. Polyak include:

  • Jessica Wagoner
  • Judith M. White
  • Joshua T. Schiffer
  • Aleksandr Ianevski
  • Stephanie T. Page

The scientist's work has been published in several venues repeatedly, most notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Antimicrobial Agents and Chemotherapy
  • AIDS
  • Journal of Ethnopharmacology
  • Gut

Stephen J. Polyak was awarded the distinction of Fellow of the John Simon Guggenheim Memorial Foundation in 1950. This award recognizes significant contributions to research fields. The scientist remains active in research endeavors related to viral infections and molecular biology, contributing to scientific knowledge and understanding of infectious disease mechanisms and therapeutic strategies.

Best Publications

  • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

    Michael J. Gale;Marcus J. Korth;Norina M. Tang;Seng Lai Tan

  • Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation

    Michael Gale;Collin M. Blakely;Bart Kwieciszewski;Seng Lai Tan

  • Arbidol as a broad-spectrum antiviral: an update.

    Julie Blaising;Stephen J. Polyak;Eve Isabelle Pécheur

  • Arbidol: a broad-spectrum antiviral compound that blocks viral fusion.

    Y. S. Boriskin;I. A. Leneva;E.-I. Pecheur;S. J. Polyak

  • Hepatitis C Virus Nonstructural 5A Protein Induces Interleukin-8, Leading to Partial Inhibition of the Interferon-Induced Antiviral Response

    Stephen J. Polyak;Khalid S. A. Khabar;Denise M. Paschal;Heather J. Ezelle

  • Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins

    Stephanie T. Shi;Stephen J. Polyak;Hong Tu;Deborah R. Taylor

  • Identification of hepatoprotective flavonolignans from silymarin

    Stephen J. Polyak;Chihiro Morishima;Volker Lohmann;Sampa Pal

  • Inhibition of T-Cell Inflammatory Cytokines, Hepatocyte NF-κB Signaling, and HCV Infection by Standardized Silymarin

    Stephen J. Polyak;Chihiro Morishima;Margaret C. Shuhart;Chia C. Wang

  • Elevated Levels of Interleukin-8 in Serum Are Associated with Hepatitis C Virus Infection and Resistance to Interferon Therapy

    Stephen J. Polyak;Khalid S. A. Khabar;Mohammed Rezeiq;David R. Gretch

  • Multiple effects of silymarin on the hepatitis C virus lifecycle.

    Jessica Wagoner;Amina Negash;Olivia J Kane;Laura E Martinez

  • Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry

    Jennifer E. Kyle;Xing Zhang;Karl K. Weitz;Matthew E. Monroe

  • Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species†

    Robert S. Tacke;Hai Chon Lee;Celeste Goh;Jeremy Courtney

  • Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase

    Yupeng He;Haruhisa Nakao;Seng Lai Tan;Stephen J. Polyak

  • A Crucial Role for Kupffer Cell-Derived Galectin-9 in Regulation of T Cell Immunity in Hepatitis C Infection

    John A. Mengshol;Lucy Golden-Mason;Tomohiro Arikawa;Maxwell Smith

  • Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication.

    Stephen J. Polyak;Denise M. Paschal;Susan McArdle;Michael J. Gale

  • Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection.

    Stephen J. Polyak;Susan McArdle;Shan Lu Liu;Daniel G. Sullivan

  • Tracking hepatitis C virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients.

    David R. Gretch;Stephen J. Polyak;Jeffrey J. Wilson;Robert L. Carithers

  • The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses

    Eve Isabelle Pécheur;Viktoriya Borisevich;Peter Halfmann;John D. Morrey

  • Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection.

    Chihiro Morishima;Margaret C. Shuhart;Chia C. Wang;Denise M. Paschal

  • Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1

    Sampa Pal;Stephen J Polyak;Nazneen Bano;Wan Chong Qiu

Frequent Co-Authors

David R. Gretch
David R. Gretch University of Washington
Nicholas H. Oberlies
Nicholas H. Oberlies University of North Carolina at Greensboro
Chihiro Morishima
Chihiro Morishima University of Washington
Hugo R. Rosen
Hugo R. Rosen University of Southern California
Michael Gale
Michael Gale University of Washington
Barbra A. Richardson
Barbra A. Richardson University of Washington
Stephen C. De Rosa
Stephen C. De Rosa Fred Hutchinson Cancer Research Center
Tero Aittokallio
Tero Aittokallio University of Helsinki
Lawrence Corey
Lawrence Corey Fred Hutchinson Cancer Research Center

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