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Chemistry

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Overview

Nicholas H. Oberlies is affiliated with the University of North Carolina at Greensboro in the United States. Their research spans multiple domains within the sciences, with a particular focus on medicine and biochemistry, genetics, and molecular biology.

Their work has contributed extensively to the fields of pharmacology, molecular biology, plant science, cell biology, and organic chemistry. Oberlies's research topics cover various areas including microbial natural products and biosynthesis, plant pathogens and fungal diseases, fungal biology and applications, chemical synthesis and alkaloids, alkaloids synthesis and pharmacology, antifungal resistance and susceptibility, and traditional and medicinal uses of Annonaceae.

They have published numerous papers in notable scientific venues. Frequent publication platforms for Oberlies's work include:

  • Journal of Natural Products
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Phytochemistry
  • UNC Libraries
  • Natural Product Reports

Some recent research papers authored or coauthored by Oberlies include:

  • Biosynthetic gene clusters and the evolution of fungal chemodiversity, 2020, Natural Product Reports
  • Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions, 2020, Scientific Reports
  • The Chemistry of Kratom Mitragyna speciosa: Updated Characterization Data and Methods to Elucidate Indole and Oxindole Alkaloids, 2020, Journal of Natural Products
  • Fungal-fungal co-culture: a primer for generating chemical diversity, 2022, Natural Product Reports
  • Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of Virulence Across Aspergillus Species, 2020, Genetics

Oberlies has regularly collaborated with several coauthors over their career. Frequent collaborators include:

  • Huzefa A. Raja
  • Cedric J. Pearce
  • Joanna E. Burdette
  • Tyler N. Graf
  • Antonis Rokas

Best Publications

  • Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community

    Huzefa A. Raja;Andrew N. Miller;Cedric J. Pearce;Nicholas H. Oberlies

  • Camptothecin and Taxol: Historic Achievements in Natural Products Research⊥

    Nicholas H. Oberlies;David J. Kroll

  • Recent advances in annonaceous acetogenins

    Lu Zeng;Qing Ye;Nicholas H. Oberlies;Guoen Shi

  • Identification of hepatoprotective flavonolignans from silymarin

    Stephen J. Polyak;Chihiro Morishima;Volker Lohmann;Sampa Pal

  • Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma

    Karen M VanderMolen;William McCulloch;Cedric J Pearce;Nicholas H Oberlies

  • Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity In vitro

    Meredith T. Morgan;Yuka Nakanishi;David J. Kroll;Aaron P. Griset

  • Milk Thistle Nomenclature: Why It Matters in Cancer Research and Pharmacokinetic Studies

    David J. Kroll;Heather S. Shaw;Nicholas H. Oberlies

  • Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.

    Paula R. Davis-Searles;Yuka Nakanishi;Nam-Cheol Kim;Tyler N. Graf

  • Multiple effects of silymarin on the hepatitis C virus lifecycle.

    Jessica Wagoner;Amina Negash;Olivia J Kane;Laura E Martinez

  • The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion.

    Chunwan Lu;Amy V. Paschall;Huidong Shi;Natasha Savage

  • Structure−Activity Relationships of Diverse Annonaceous Acetogenins against Multidrug Resistant Human Mammary Adenocarcinoma (MCF-7/Adr) Cells

    Nicholas H. Oberlies;Ching-jer Chang;Jerry L. McLaughlin

  • Mode of action of bullatacin, a potent antitumor acetogenin: Inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes.

    D J Morré;R de Cabo;C Farley;N H Oberlies

  • Fungal Planet description sheets: 716-784.

    Pedro W. Crous;Michael J. Wingfield;T.I. Burgess;G.E.St.J. Hardy

  • Fungal Planet Description Sheets: 371-399

    P W Crous;M J Wingfield;J J Le Roux;D M Richardson

  • Fingolimod (FTY720): A Recently Approved Multiple Sclerosis Drug Based on a Fungal Secondary Metabolite

    Cherilyn R. Strader;Cedric J. Pearce;Nicholas H. Oberlies

  • The Annonaceous Acetogenin Bullatacin Is Cytotoxic against Multidrug Resistant Human Mammary Adenocarcinoma Cells

    Nicholas H. Oberlies;Vicki L. Croy;Marietta L. Harrison;Jerry L. McLaughlin

  • Novel Strategies for the Discovery of Plant-Derived Anticancer Agents

    A. Kinghorn;Norman Farnsworth;Djaja Soejarto;Geoffrey Cordell

  • Antioxidant activity and total phenolic content of aqueous and methanolic extracts of Jordanian plants: an ICBG project

    Feras Q. Alali;Khaled Tawaha;Tamam El-Elimat;Maha Syouf

  • High-Resolution MS, MS/MS, and UV Database of Fungal Secondary Metabolites as a Dereplication Protocol for Bioactive Natural Products

    Tamam El-Elimat;Mario Figueroa;Brandie M. Ehrmann;Nadja B. Cech

  • Mechanisms Underlying Food-Drug Interactions: Inhibition of Intestinal Metabolism and Transport

    Christina S. Won;Nicholas H. Oberlies;Mary F. Paine

  • Novel Strategies for the Discovery of Plant-Derived Anticancer Agents

    G. A. Cordell;N. R. Farnsworth;C. W. W. Beecher;D. D. Soejarto

Frequent Co-Authors

Mansukh C. Wani
Mansukh C. Wani Research Triangle Park Foundation
Joseph O. Falkinham
Joseph O. Falkinham Virginia Tech
Rajesh Agarwal
Rajesh Agarwal University of Colorado Anschutz Medical Campus
Stephen J. Polyak
Stephen J. Polyak University of Washington
A. Douglas Kinghorn
A. Douglas Kinghorn The Ohio State University
Antonis Rokas
Antonis Rokas Vanderbilt University
Gagan Deep
Gagan Deep Wake Forest University
Jerry L. McLaughlin
Jerry L. McLaughlin Purdue University West Lafayette
Kebin Liu
Kebin Liu Augusta University
Mark W. Grinstaff
Mark W. Grinstaff Boston University

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