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Immunology

D-Index
52
Citations
18606
World Ranking
4020
National Ranking
1834

Overview

Stephen C. De Rosa is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research primarily focuses on immunology, microbiology, and medicine, with a particular emphasis on HIV research and treatment.

Their work spans several subfields including virology, immunology, infectious diseases, radiology, nuclear medicine and imaging, and molecular biology. Central themes in their research involve monoclonal and polyclonal antibodies, immunotherapy and immune responses, HIV/AIDS drug development and treatment, vaccines and immunoinformatics approaches, immune cell function and interaction, and T-cell and B-cell immunology.

De Rosa has published in various scientific venues, with repeated publications in EBioMedicine. Other notable journals include Science Translational Medicine, Vaccine, and the Proceedings of the National Academy of Sciences.

  • Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial (2025, Science Translational Medicine)
  • Safety and immunogenicity of a recombinant oligomeric gp145 subtype C Env protein (gp145 C.6980) HIV vaccine candidate in healthy, HIV-1-uninfected adult participants in the US (2023, Vaccine)
  • Regulation of CD45 isoforms during human effector and memory CD8 T cell differentiation: Implications for T cell nomenclature (2025, Proceedings of the National Academy of Sciences)
  • Corrigendum to 'Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study'. EBioMedicine 2024;108: 105320 (2025, EBioMedicine)
  • Unbiased cell clustering analysis of vaccine-induced T cell responses in the Imbokodo HIV-1 vaccine trial (2025, EBioMedicine)

Frequent collaborators include Jack Heptinstall, Kelly E. Seaton, Georgia D. Tomaras, M. Juliana McElrath, and Shannon Grant. Each has co-authored multiple publications alongside De Rosa.

The scientist's main areas of contribution intersect with immunological mechanisms and vaccine development against HIV, addressing both cellular immune responses and broader immunoinformatic approaches. Their research contributes to understanding T-cell and B-cell immunology in the context of infectious disease and vaccine efficacy.

Best Publications

  • HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells

    Michael R. Betts;Martha C. Nason;Sadie M. West;Stephen C. De Rosa

  • Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

    Barton F. Haynes;Peter B. Gilbert;M. Juliana McElrath;Susan Zolla-Pazner

  • Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

    Michael R. Betts;Jason M. Brenchley;David A. Price;Stephen C. De Rosa

  • Interim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine.

    Jerald Sadoff;Mathieu Le Gars;Georgi Shukarev;Dirk Heerwegh

  • HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis

    M Juliana McElrath;M Juliana McElrath;Stephen C De Rosa;Stephen C De Rosa;Zoe Moodie;Sheri Dubey

  • 11-color, 13-parameter flow cytometry: Identification of human naive T cells by phenotype, function, and T-cell receptor diversity

    Stephen C. De Rosa;Leonard A. Herzenberg;Leonore A. Herzenberg;Mario Roederer

  • mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection.

    Leonidas Stamatatos;Leonidas Stamatatos;Julie Czartoski;Yu Hsin Wan;Leah J. Homad

  • Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells.

    Kristen W. Cohen;Susanne L. Linderman;Zoe Moodie;Julie Czartoski

  • Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry

    Pratip K Chattopadhyay;David A Price;Theresa F Harper;Michael R Betts;Michael R Betts

  • Safety and Immunogenicity of Novel Adenovirus Type 26– and Modified Vaccinia Ankara–Vectored Ebola Vaccines: A Randomized Clinical Trial

    Iain D. Milligan;Malick M. Gibani;Richard Sewell;Elizabeth A. Clutterbuck

  • The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression.

    Pratip K. Chattopadhyay;Michael R. Betts;David A. Price;Emma Gostick

  • COMPASS identifies T-cell subsets correlated with clinical outcomes

    Lin Lin;Greg Finak;Kevin Ushey;Chetan Seshadri

  • Beyond six colors: a new era in flow cytometry.

    Stephen C. De Rosa;Jason M. Brenchley;Mario Roederer

  • Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T cells induced by vaccination.

    Helen Horton;Evan P. Thomas;Jason A. Stucky;Ian Frank

  • Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery

    Spyros A. Kalams;Scott D. Parker;Marnie Elizaga;Barbara Metch

  • Ontogeny of γδ T Cells in Humans

    Stephen C. De Rosa;James P. Andrus;Stephen P. Perfetto;John J. Mantovani

  • Vaccination in Humans Generates Broad T Cell Cytokine Responses

    Stephen C. De Rosa;Fabien X. Lu;Joanne Yu;Stephen P. Perfetto

  • OpenCyto: An Open Source Infrastructure for Scalable, Robust, Reproducible, and Automated, End-to-End Flow Cytometry Data Analysis

    Greg Finak;Jacob Frelinger;Wenxin Jiang;Evan W. Newell

  • Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells.

    Yvonne M Mueller;Stephen C De Rosa;Justin A Hutton;James Witek

  • Chronic elevation of plasma thioredoxin: inhibition of chemotaxis and curtailment of life expectancy in AIDS.

    Hajime Nakamura;Stephen C. De Rosa;Junji Yodoi;Arne Holmgren

Frequent Co-Authors

M. Juliana McElrath
M. Juliana McElrath University of Washington
Lawrence Corey
Lawrence Corey Fred Hutchinson Cancer Research Center
Georgia D. Tomaras
Georgia D. Tomaras Duke University
Mario Roederer
Mario Roederer National Institute of Allergy and Infectious Diseases
Nicole Frahm
Nicole Frahm Fred Hutchinson Cancer Research Center
Raphael Gottardo
Raphael Gottardo Fred Hutchinson Cancer Research Center
Peter B. Gilbert
Peter B. Gilbert Fred Hutchinson Cancer Research Center
Leonard A. Herzenberg
Leonard A. Herzenberg Stanford University
David C. Montefiori
David C. Montefiori Duke University
Leonore A. Herzenberg
Leonore A. Herzenberg Stanford University

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