World's Best Scientists 2026 revealed!
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Microbiology
Japan
2026

D-Index & Metrics

Microbiology

D-Index
96
Citations
39116
World Ranking
496
National Ranking
14

Medicine

D-Index
97
Citations
39421
World Ranking
9189
National Ranking
243

Research.com Recognitions

  • 2026 - Research.com Microbiology in Japan Leader Award

Overview

Kunitada Shimotohno is affiliated with the National Center For Global Health and Medicine in Japan. Their research spans several fields within medicine and molecular biology, with a focus on epidemiology, hepatology, infectious diseases, immunology, and molecular biology.

The primary topics in Shimotohno's work include:

  • Hepatitis B Virus Studies
  • Hepatitis C virus research
  • Liver Disease Diagnosis and Treatment
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Immunotherapy and Immune Responses
  • MicroRNA in disease regulation

Shimotohno has contributed to numerous publications, many of which appear in specific scientific venues. Frequent publication venues include:

  • International Journal of Molecular Sciences
  • Journal of Virology
  • Gene
  • Nature Communications
  • Hepatology

Notable recent publications by Shimotohno include:

  • SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype (2020, Gene)
  • Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins (2022, Nature Communications)
  • Ubiquitination of SARS-CoV-2 NSP6 and ORF7a Facilitates NF-κB Activation (2022, mBio)
  • Role of microRNA-210-3p in hepatitis B virus-related hepatocellular carcinoma (2020, American Journal of Physiology-Gastrointestinal and Liver Physiology)
  • Angiotensin-Converting Enzyme (ACE) 1 Gene Polymorphism and Phenotypic Expression of COVID-19 Symptoms (2021, Genes)

Shimotohno collaborates with several frequent co-authors, indicating an active role in multidisciplinary scientific networks. These collaborators include:

  • Hironori Nishitsuji
  • Masashi Mizokami
  • Takaji Wakita
  • Masaya Sugiyama
  • Takanobu Kato

The main fields of study associated with Shimotohno's research are:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Subfields are focused particularly on:

  • Epidemiology
  • Hepatology
  • Infectious Diseases
  • Immunology
  • Molecular Biology

Best Publications

  • Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis

    Nobuyuki Kato;Makoto Hijikata;Yuko Ootsuyama;Masanori Nakagawa

  • Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues

    Y Murakami;T Yasuda;K Saigo;T Urashima

  • The lipid droplet is an important organelle for hepatitis C virus production.

    Yusuke Miyanari;Kimie Atsuzawa;Nobuteru Usuda;Koichi Watashi

  • A proposed system for the nomenclature of hepatitis C viral genotypes

    P Simmonds;A Alberti;H J Alter;F Bonino

  • Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.

    Makoto Hijikata;Nobuyuki Kato;Yuko Ootsuyama;Masanori Nakagawa

  • Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus.

    M Hijikata;H Mizushima;T Akagi;S Mori

  • Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b.

    Akiko Tsumura;Tomohiro Hayakawa;Yuichi Kumaki;Shin-ichiro Takebayashi

  • Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes.

    Koichi Watashi;Makoto Hijikata;Masahiro Hosaka;Masashi Yamaji

  • Cyclophilin B Is a Functional Regulator of Hepatitis C Virus RNA Polymerase

    Koichi Watashi;Naoto Ishii;Makoto Hijikata;Daisuke Inoue

  • Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125

    Kei-ichiro Arimoto;Hitoshi Takahashi;Takayuki Hishiki;Hideyuki Konishi

  • Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus.

    N Kato;H Sekiya;Y Ootsuyama;T Nakazawa

  • Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

    Akio Matsuda;Akio Matsuda;Yutaka Suzuki;Goichi Honda;Shuji Muramatsu

  • Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus

    Makoto Hijikata;Hiroto Mizushima;Yasunori Tanji;Yasumasa Komoda

  • Hypervariable regions in the putative glycoprotein of hepatitis C virus.

    Makoto Hijikata;Nobuyuki Kato;Yuko Ootsuyama;Masanori Nakagawa

  • Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-kappaB activation.

    Hiroyuki Marusawa;Makoto Hijikata;Tsutomu Chiba;Kunitada Shimotohno

  • Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene

    Kunitada Shimotohno;Yuri Takahashi;Nobuaki Shimizu;Takashi Gojobori

  • Structure of the 3' terminus of the hepatitis C virus genome.

    Torahiko Tanaka;Nobuyuki Kato;Myung J.E. Cho;Kazuo Sugiyama

  • A Novel Sequence Found at the 3′-Terminus of Hepatitis C Virus Genome

    T. Tanaka;Nobuyuki Kato;M. J. Cho;K. Shimotohno

  • Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A.

    Yasunori Tanji;Takashi Kaneko;Shinya Satoh;Kunitada Shimotohno

  • Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction

    Tomohiro Kinoshita;Masanori Shimoyama;Kensei Tobinai;Mizuko Ito

  • Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing.

    Yasunori Tanji;Makoto Hijikata;Shinya Satoh;Takasi Kaneko

  • Latent hepatitis B virus infection in healthy individuals with antibodies to hepatitis B core antigen.

    Hiroyuki Marusawa;Shinji Uemoto;Makoto Hijikata;Yoshihide Ueda

  • The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families

    Yoshiki Murakami;Hidenori Toyoda;Masami Tanaka;Masahiko Kuroda

  • Sequence of retrovirus provirus resembles that of bacterial transposable elements

    Kunitada Shimotohno;Satoshi Mizutani;Howard M. Temin

Frequent Co-Authors

Nobuyuki Kato
Nobuyuki Kato Okayama University
Koichi Watashi
Koichi Watashi National Institute of Infectious Diseases
Takashi Sugimura
Takashi Sugimura National Cancer Centre
Tetsuya Mizutani
Tetsuya Mizutani Tokyo University of Agriculture and Technology
Yasunori Tanji
Yasunori Tanji Tokyo Institute of Technology
Takaji Wakita
Takaji Wakita National Institute of Infectious Diseases
Masao Hattori
Masao Hattori University of Toyama
Masanao Miwa
Masanao Miwa Nagahama Institute of Bio-Science and Technology
Hiroyuki Marusawa
Hiroyuki Marusawa Kyoto University
Tsutomu Chiba
Tsutomu Chiba Kyoto University

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