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Robert H. Silverman

Robert H. Silverman

D-Index & Metrics

Microbiology

D-Index
92
Citations
39753
World Ranking
612
National Ranking
283

Molecular Biology

D-Index
92
Citations
39599
World Ranking
692
National Ranking
378

Research.com Recognitions

  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Robert H. Silverman is affiliated with Kent State University in the United States. Their research spans multiple interconnected fields including Medicine, Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology, with a focus on subfields such as Molecular Biology, Immunology, Infectious Diseases, Cancer Research, and Cardiology and Cardiovascular Medicine.

Their main scientific topics of work include interferon and immune responses, SARS-CoV-2 and COVID-19 research, RNA regulation and disease, viral gastroenteritis research and epidemiology, RNA research and splicing, viral infections and immunology research, and NF-κB signaling pathways.

Selected recent papers by Robert H. Silverman include:

  • SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes, 2021, Proceedings of the National Academy of Sciences
  • Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children, 2022, Science
  • COVID-19: Coronavirus replication, pathogenesis, and therapeutic strategies, 2020, Cleveland Clinic Journal of Medicine
  • SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • H3K9 methylation drives resistance to androgen receptor-antagonist therapy in prostate cancer, 2022, Proceedings of the National Academy of Sciences

Frequent coauthors throughout their career include Abhishek Asthana, Beihua Dong, Christina Gaughan, Susan R. Weiss, and Babal K. Jha.

Silverman's work has been published extensively in prominent journals. Their frequent publication venues include Proceedings of the National Academy of Sciences, bioRxiv (Cold Spring Harbor Laboratory), The EMBO Journal, SSRN Electronic Journal, and Science.

In recognition of their scientific contributions, Robert H. Silverman was awarded the title of Fellow of the American Association for the Advancement of Science (AAAS) in 2008.

Best Publications

  • How cells respond to interferons

    George R. Stark;Ian M. Kerr;Bryan R. G. Williams;Robert H. Silverman

  • Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays

    Sandy D. Der;Aimin Zhou;Bryan R. G. Williams;Robert H. Silverman

  • Activation of the interferon system by short-interfering RNAs

    Carol A Sledz;Carol A Sledz;Michelle Holko;Michelle Holko;Michael John de Veer;Robert H Silverman;Robert H Silverman

  • Interferons at age 50: past, current and future impact on biomedicine.

    Ernest C Borden;Ganes Sen;Gilles Uze;Robert H Silverman

  • Functional classification of interferon-stimulated genes identified using microarrays

    Michael John de Veer;Michelle Holko;Michelle Holko;Mathias A E Frevel;Eldon Walker

  • Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis.

    Mamta Chawla-Sarkar;Daniel J Lindner;Y-F Liu;Bryan Raymond George Williams

  • Viral Encounters with 2′,5′-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response

    Robert H. Silverman

  • Tat trans-activates the human immunodeficiency virus through a nascent RNA target

    Ben Berkhout;Robert H. Silverman;Kuan-Teh Jeang

  • Small self-RNA generated by RNase L amplifies antiviral innate immunity

    Krishnamurthy Malathi;Beihua Dong;Michael Gale;Robert H. Silverman

  • Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action

    Aimin Zhou;Bret A. Hassel;Bret A. Hassel;Robert H. Silverman;Robert H. Silverman

  • Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome.

    Vincent C. Lombardi;Francis W. Ruscetti;Jaydip Das Gupta;Max A. Pfost

  • Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant

    Anatoly Urisman;Ross J Molinaro;Ross J Molinaro;Nicole Fischer;Sarah J Plummer

  • Interferon action and apoptosis are defective in mice devoid of 2′,5′‐oligoadenylate‐dependent RNase L

    Aimin Zhou;Aimin Zhou;Jayashree Paranjape;Thomas L. Brown;Huiqin Nie

  • Germline mutations in the ribonuclease L gene in families showing linkage with HPC1.

    J. Carpten;N. Nupponen;S. Isaacs;R. Sood

  • Nucleoside modifications in RNA limit activation of 2′-5′-oligoadenylate synthetase and increase resistance to cleavage by RNase L

    Bart R. Anderson;Hiromi Muramatsu;Babal K. Jha;Robert H. Silverman

  • A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon.

    Bret A. Hassel;Aimin Zhou;Carole Sotomayor;Avudaiappan Maran

  • RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases.

    Graham Casey;Phillippa J. Neville;Sarah J. Plummer;Ying Xiang

  • New Insights into the Role of RNase L in Innate Immunity

    Arindam Chakrabarti;Babal Kant Jha;Robert H. Silverman

  • 2-5A-dependent RNase Molecules Dimerize during Activation by 2-5A

    Beihua Dong;Robert H. Silverman

  • Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways

    Wolfgang W. Leitner;Leroy N. Hwang;Michael J. deVeer;Aimin Zhou

Frequent Co-Authors

Susan R. Weiss
Susan R. Weiss University of Pennsylvania
Eric A. Klein
Eric A. Klein Cleveland Clinic
Michael Gale
Michael Gale University of Washington
Daniel J. J. Carr
Daniel J. J. Carr University of Oklahoma Health Sciences Center
Warren D.W. Heston
Warren D.W. Heston Case Western Reserve University
Ian M. Kerr
Ian M. Kerr The Honourable Society of Lincoln's Inn
Peter J. Sims
Peter J. Sims University of Rochester
Francois Villinger
Francois Villinger University of Louisiana at Lafayette
Frank Sicheri
Frank Sicheri Lunenfeld-Tanenbaum Research Institute
Don Ganem
Don Ganem Via Nova Therapeutics

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