World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
77
Citations
24925
World Ranking
1101
National Ranking
37

Research.com Recognitions

  • 2011 - Fellow of the Royal Society of Canada Academy of Science

Overview

Frank Sicheri is affiliated with the Lunenfeld-Tanenbaum Research Institute in Canada. Their research activity spans several key areas within biochemistry, genetics, molecular biology, and medicine, producing a substantial volume of publications primarily focused on molecular biology and oncology.

The scientist has contributed extensively to the following main fields of study:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these areas, their work delves into various subfields, including:

  • Molecular Biology
  • Oncology
  • Cell Biology
  • Infectious Diseases
  • Materials Chemistry

The primary topics Frank Sicheri's research encompasses are:

  • Ubiquitin and proteasome pathways
  • Peptidase Inhibition and Analysis
  • Protein Degradation and Inhibitors
  • Microtubule and mitosis dynamics
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • DNA Repair Mechanisms

Frequent collaborators include:

  • Stephen Orlicky (14 publications)
  • Igor Kurinov (12 publications)
  • Derek F. Ceccarelli (10 publications)
  • Daniel Y.L. Mao (9 publications)
  • Pierre Maisonneuve (8 publications)

Frank Sicheri often publishes in the following scientific venues:

  • bioRxiv (Cold Spring Harbor Laboratory) - 8 publications
  • Nature Communications - 6 publications
  • Journal of Medicinal Chemistry - 5 publications
  • Structure - 3 publications
  • ACS Chemical Biology - 2 publications

Selected recent publications are as follows:

  • Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients, 2020, Science Immunology
  • Functional characterization of a PROTAC directed against BRAF mutant V600E, 2020, Nature Chemical Biology
  • Mucosal versus systemic antibody responses to SARS-CoV-2 antigens in COVID-19 patients, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306, 2022, Journal of Medicinal Chemistry
  • Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ, 2022, Journal of Medicinal Chemistry

Among their recognitions, Frank Sicheri was named a Fellow of the Royal Society of Canada in 2011 by the Academy of Science.

Best Publications

  • Crystal structure of the Src family tyrosine kinase Hck

    Frank Sicheri;Ismail Moarefi;Ismail Moarefi;John Kuriyan;John Kuriyan

  • Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

    Piers Nash;Xiaojing Tang;Stephen Orlicky;Qinghua Chen

  • Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients.

    Baweleta Isho;Kento T. Abe;Kento T. Abe;Michelle Zuo;Alainna J. Jamal;Alainna J. Jamal

  • Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

    I Moarefi;M LaFevre-Bernt;F Sicheri;M Huse

  • 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

    Amélie Fradet-Turcotte;Marella D. Canny;Cristina Escribano-Díaz;Alexandre Orthwein

  • Bone recognition mechanism of porcine osteocalcin from crystal structure.

    Quyen Q. Hoang;Frank Sicheri;Frank Sicheri;Andrew J. Howard;Daniel S. C. Yang

  • Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase

    Stephen Orlicky;Xiaojing Tang;Andrew Willems;Mike Tyers;Mike Tyers

  • Crystal Structure of Hck in Complex with a Src Family–Selective Tyrosine Kinase Inhibitor

    Thomas Schindler;Frank Sicheri;Alexander Pico;Aviv Gazit

  • A dimerization-dependent mechanism drives RAF catalytic activation

    Thanashan Rajakulendran;Malha Sahmi;Martin Lefrançois;Frank Sicheri

  • Ice-binding structure and mechanism of an antifreeze protein from winter flounder

    F. Sicheri;D. S. C. Yang;D. S. C. Yang

  • Structures of Src-family tyrosine kinases.

    Frank Sicheri;John Kuriyan

  • A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein

    Marilyn Goudreault;Lisa M. D'Ambrosio;Lisa M. D'Ambrosio;Michelle J. Kean;Michelle J. Kean;Michael J. Mullin

  • Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions

    Amber L. Couzens;James D. R. Knight;Michelle J. Kean;Michelle J. Kean;Guoci Teo

  • Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

    Arvin C. Dar;Thomas E. Dever;Frank Sicheri;Frank Sicheri

  • Structural Basis for Autoinhibition of the EphB2 Receptor Tyrosine Kinase by the Unphosphorylated Juxtamembrane Region

    Leanne E. Wybenga-Groot;Leanne E. Wybenga-Groot;Berivan Baskin;Siew Hwa Ong;Jiefei Tong

  • Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

    Madhusudan Dey;Chune Cao;Arvin C. Dar;Arvin C. Dar;Tomohiko Tamura

  • Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

    Kenneth P.K. Lee;Madhusudan Dey;Dante Neculai;Chune Cao

  • Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

    Shinichiro Nakada;Ikue Tai;Stephanie Panier;Stephanie Panier;Abdallah Al-Hakim

  • Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor.

    Tanja Mittag;Stephen Orlicky;Wing-Yiu Choy;Xiaojing Tang

  • Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT Domain

    Abiodun A. Ogunjimi;Douglas J. Briant;Nadia Pece-Barbara;Christine Le Roy

Frequent Co-Authors

Mike Tyers
Mike Tyers University of Montreal
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
Daniel Durocher
Daniel Durocher Lunenfeld-Tanenbaum Research Institute
Sachdev S. Sidhu
Sachdev S. Sidhu University of Waterloo
Tony Pawson
Tony Pawson University of Toronto
Jeffrey L. Wrana
Jeffrey L. Wrana Lunenfeld-Tanenbaum Research Institute
Julie D. Forman-Kay
Julie D. Forman-Kay University of Toronto
John Kuriyan
John Kuriyan Vanderbilt University
Thomas E. Dever
Thomas E. Dever National Institutes of Health
Alain Fischer
Alain Fischer Collège de France

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