What is he best known for?
The fields of study he is best known for:
His primary areas of investigation include Biochemistry, Cell biology, Phosphorylation, Ubiquitin ligase and Ubiquitin.
Kinase, SH2 domain, Receptor tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src and SH3 domain are subfields of Biochemistry in which his conducts study.
His biological study spans a wide range of topics, including RNA and Protein biosynthesis.
His Cell biology research incorporates themes from Protein structure and Protein kinase domain.
His Ubiquitin ligase research is multidisciplinary, incorporating elements of DNA ligase and Sic1.
His study focuses on the intersection of Ubiquitin and fields such as Enzyme with connections in the field of Mutagenesis, Receptor complex and Ubiquitin ligase activity.
His most cited work include:
- Crystal structure of the Src family tyrosine kinase Hck (1043 citations)
- Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication (669 citations)
- Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication (669 citations)
What are the main themes of his work throughout his whole career to date?
Frank Sicheri mainly focuses on Cell biology, Biochemistry, Ubiquitin, Kinase and Ubiquitin ligase.
His work in Cell biology covers topics such as Protein kinase domain which are related to areas like Kinase activity and Receptor tyrosine kinase.
His research on Biochemistry often connects related areas such as Biophysics.
He has included themes like DNA ligase and Enzyme in his Ubiquitin study.
Frank Sicheri interconnects Cyclin-dependent kinase and Allosteric regulation in the investigation of issues within Ubiquitin ligase.
His Cell division control protein 4 research includes themes of Sic1 and F-box protein.
He most often published in these fields:
- Cell biology (83.91%)
- Biochemistry (76.25%)
- Ubiquitin (41.00%)
What were the highlights of his more recent work (between 2018-2021)?
- Cell biology (83.91%)
- Ubiquitin (41.00%)
- Kinase (40.23%)
In recent papers he was focusing on the following fields of study:
Frank Sicheri spends much of his time researching Cell biology, Ubiquitin, Kinase, Deubiquitinating enzyme and Plasma protein binding.
His work focuses on many connections between Cell biology and other disciplines, such as Binding site, that overlap with his field of interest in Enzyme kinetics.
His work deals with themes such as Active site, Enzyme, Phage display and Function, which intersect with Ubiquitin.
His Phage display study introduces a deeper knowledge of Biochemistry.
His Kinase research is multidisciplinary, incorporating perspectives in Cancer research, Signal transduction, Protein kinase domain and Effector.
The various areas that he examines in his Plasma protein binding study include Catalytic cycle, Gene, Archaea and Transfer RNA, TRNA modification.
Between 2018 and 2021, his most popular works were:
- Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. (158 citations)
- Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. (158 citations)
- Mucosal versus systemic antibody responses to SARS-CoV-2 antigens in COVID-19 patients (29 citations)
In his most recent research, the most cited papers focused on:
His primary scientific interests are in Kinase, Cell biology, Antibody response, Immunology and Antibody.
His Kinase study incorporates themes from Cell culture, Cancer research and Signal transduction.
His Signal transduction research incorporates elements of Plasma protein binding, Cell growth, V600E, Mutant and Regulation of gene expression.
Frank Sicheri combines subjects such as Ubiquitin, Protein kinase domain and Pyrazolopyrimidine, Pyrimidine with his study of Cell biology.
The Ubiquitin study combines topics in areas such as Function, Phosphorylation and Active site.
His research investigates the connection between Immunology and topics such as Enzyme that intersect with problems in Ubiquitin-conjugating enzyme, NEDD8, Chemical biology and F-box protein.
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