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Biology and Biochemistry

D-Index
91
Citations
28979
World Ranking
2328
National Ranking
1245

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Ganes C. Sen is affiliated with Case Western Reserve University in the United States. Their research spans multiple fields primarily focused on immunology, microbiology, medicine, and biochemistry, genetics, and molecular biology. The scientist's work intersects subfields including immunology, molecular biology, infectious diseases, oncology, and cancer research.

The research topics covered by Ganes C. Sen include:

  • Interferon and immune responses
  • RNA regulation and disease
  • Immune response and inflammation
  • Viral infections and vectors
  • Cytokine signaling pathways and interactions
  • Inflammasome and immune disorders
  • SARS-CoV-2 and COVID-19 research

Ganes C. Sen has published extensively in various scientific journals. Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), PLoS Pathogens, mBio, Journal of Virology, and Proceedings of the National Academy of Sciences.

Notable recent papers include:

  • "Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis" (2020, Nature Communications)
  • "Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production" (2020, Journal of Clinical Investigation)
  • "EGFR-mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions" (2020, The EMBO Journal)
  • "IRF3 inhibits nuclear translocation of NF-κB to prevent viral inflammation" (2022, Proceedings of the National Academy of Sciences)
  • "PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation" (2020, eLife)

Throughout their career, Ganes C. Sen has collaborated frequently with other researchers. Some of the most frequent coauthors include Patricia Kessler, Nikhil Sharma, Chenyao Wang, Amy Burrows, and Jayasri Das Sarma.

Ganes C. Sen was recognized with the fellowship of the American Association for the Advancement of Science (AAAS) in 2007.

Best Publications

  • Interferons at age 50: past, current and future impact on biomedicine.

    Ernest C Borden;Ganes Sen;Gilles Uze;Robert H Silverman

  • Viruses and Interferons

    Ganes C. Sen

  • Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis.

    Mamta Chawla-Sarkar;Daniel J Lindner;Y-F Liu;Bryan Raymond George Williams

  • 2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

    Stephane Daffis;Kristy J. Szretter;Jill Schriewer;Jianqing Li

  • The interferon system. A bird's eye view of its biochemistry.

    Ganes Sen;Peter Lengyel

  • PACT, a protein activator of the interferon‐induced protein kinase, PKR

    Rekha C. Patel;Ganes C. Sen

  • Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes.

    Nathalie Grandvaux;Marc J. Servant;Benjamin tenOever;Ganes C. Sen

  • Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β

    Zhengfan Jiang;Tak W. Mak;Ganes Sen;Xiaoxia Li

  • Interferons and viral infections.

    Volker Fensterl;Ganes C. Sen

  • Interferon-induced antiviral actions and their regulation.

    Ganes C. Sen;Richard M. Ransohoff

  • Attenuation of cGAS-STING Signaling Is Mediated by a p62/SQSTM1-dependent Autophagy Pathway Activated by TBK1

    Thaneas Prabakaran;Chiranjeevi Bodda;Chiranjeevi Bodda;Christian Krapp;Bao‐cun Zhang

  • Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling.

    Saumendra N Sarkar;Kristi L Peters;Christopher P Elco;Shuji Sakamoto

  • Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA

    Shoudong Li;Ji Young Min;Robert M Krug;Ganes C. Sen;Ganes C. Sen

  • Interferon, double-stranded RNA, and protein phosphorylation

    B. Lebleu;Ganes Sen;S. Shaila;B. Cabrer

  • A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis.

    Ji Young Min;Shoudong Li;Ganes C. Sen;Robert M Krug

  • The ISG56/IFIT1 gene family

    Volker Fensterl;Ganes C. Sen

  • Interferon-induced Ifit proteins: Their role in viral pathogenesis

    Volker Fensterl;Ganes C. Sen

  • Transcriptional signaling by double-stranded RNA: role of TLR3.

    Ganes C. Sen;Saumendra N. Sarkar

  • A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity

    Tae Whan Kim;Kirk Staschke;Katarzyna Bulek;Jianhong Yao

  • Viral apoptosis is induced by IRF-3-mediated activation of Bax.

    Saurabh Chattopadhyay;Joao Trindade Marques;Michifumi Yamashita;Kristi L Peters

Frequent Co-Authors

Xiaoxia Li
Xiaoxia Li Cleveland Clinic Lerner College of Medicine
Robert H. Silverman
Robert H. Silverman Kent State University
Cornelia C. Bergmann
Cornelia C. Bergmann Cleveland Clinic
Stephen A. Stohlman
Stephen A. Stohlman Cleveland Clinic
Laura E. Nagy
Laura E. Nagy Cleveland Clinic
Thomas A. Hamilton
Thomas A. Hamilton Cleveland Clinic
William C. Merrick
William C. Merrick Case Western Reserve University
Ernest C. Borden
Ernest C. Borden Cleveland Clinic
Michael S. Diamond
Michael S. Diamond Washington University in St. Louis

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