World's Best Scientists 2026 revealed!
Thomas A. Hamilton

Thomas A. Hamilton

D-Index & Metrics

Biology and Biochemistry

D-Index
84
Citations
23854
World Ranking
3336
National Ranking
1684

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Thomas A. Hamilton is affiliated with the Cleveland Clinic in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, immunology, and microbiology. Their publication record includes significant contributions to molecular biology, immunology, genetics, oncology, and biomaterials.

The scientist's work covers several main topics, including:

  • Immune cells in cancer
  • Immune Cell Function and Interaction
  • CRISPR and Genetic Engineering
  • Bacterial Genetics and Biotechnology
  • Gut microbiota and health
  • Epigenetics and DNA Methylation
  • Phagocytosis and Immune Regulation

They have frequently published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Cancer
  • Cellular and Molecular Immunology
  • Ear and Hearing
  • ACS Synthetic Biology

Their recent papers include:

  • Pharmacological inhibition of BACE1 suppresses glioblastoma growth by stimulating macrophage phagocytosis of tumor cells, 2021, Nature Cancer
  • Type I interferon signaling facilitates resolution of acute liver injury by priming macrophage polarization, 2023, Cellular and Molecular Immunology
  • The Use of Person-centered Language in Medical Research Articles Focusing on Hearing Loss or Deafness, 2022, Ear and Hearing
  • De Novo Synthesis of a Conjugative System from Human Gut Metagenomic Data for Targeted Delivery of Cas9 Antimicrobials, 2023, ACS Synthetic Biology
  • Blockade or deficiency of PD-L1 expression in intestinal allograft accelerates graft tissue injury in mice, 2021, American Journal of Transplantation

Frequent co-authors in their publications have included:

  • Benjamin R. Joris
  • Tyler S. Browne
  • Gregory B. Gloor
  • David R. Edgell
  • George R. Stark

Thomas A. Hamilton's work has been recognized by the American Association for the Advancement of Science (AAAS), which named them a Fellow in 2010.

Best Publications

  • The Cell Biology of Macrophage Activation

    Dolph O. Adams;Thomas A. Hamilton

  • TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

    Vladimir Toshchakov;Bryan W Jones;Pin-Yu Perera;Karen Thomas

  • The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease

    Youcun Qian;Caini Liu;Justin Hartupee;Cengiz Zubeyir Altuntas

  • Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis.

    R M Ransohoff;T A Hamilton;M Tani;M H Stoler

  • Synergy between Interferon-γ and Tumor Necrosis Factor-α in Transcriptional Activation Is Mediated by Cooperation between Signal Transducer and Activator of Transcription 1 and Nuclear Factor κB

    Yoshihiro Ohmori;Robert D. Schreiber;Thomas A. Hamilton

  • Hypoxic induction of interleukin-8 gene expression in human endothelial cells.

    M. Karakurum;R. Shreeniwas;Jing Xian Chen;David J. Pinsky

  • Molecular mechanisms of signal transduction in macrophages

    Thomas A. Hamilton;Dolph O. Adams

  • Regulation of Macrophage Chemokine Expression by Lipopolysaccharide In Vitro and In Vivo

    Karen M. Kopydlowski;Cindy A. Salkowski;M. Joshua Cody;Nico van Rooijen

  • The CXC Chemokines IP-10 and Mig Are Necessary for IL-12-Mediated Regression of the Mouse RENCA Tumor

    Charles S. Tannenbaum;Raymond Tubbs;David Armstrong;James H. Finke

  • IL-17 enhances chemokine gene expression through mRNA stabilization

    Justin Hartupee;Caini Liu;Michael Novotny;Xiaoxia Li

  • Molecular transductional mechanisms by which IFN gamma and other signals regulate macrophage development.

    Dolph O. Adams;Thomas A. Hamilton

  • Inhibition of IFN-γ-Induced Class II Transactivator Expression by a 19-kDa Lipoprotein from Mycobacterium tuberculosis: A Potential Mechanism for Immune Evasion

    Rish K. Pai;Marilyn Convery;Thomas A. Hamilton;W. Henry Boom

  • Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter.

    Yoshihiro Ohmori;Thomas A Hamilton

  • Requirement for STAT1 in LPS-induced gene expression in macrophages.

    Yoshihiro Ohmori;Thomas A. Hamilton

  • A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity

    Tae Whan Kim;Kirk Staschke;Katarzyna Bulek;Jianhong Yao

  • A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense

    Thais P. Salazar-Mather;Thomas A. Hamilton;Christine A. Biron

  • Cutting edge: The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease

    Michael T. Liu;Benjamin P. Chen;Patricia Oertel;Michael J. Buchmeier

  • The interferon-stimulated response element and a kappa B site mediate synergistic induction of murine IP-10 gene transcription by IFN-gamma and TNF-alpha

    Yoshihiro Ohmori;Thomas A. Hamilton

  • Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites

    M Introna;VV Alles;M Castellano;G Picardi

  • Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF).

    Dongxu Sun;Michael Novotny;Katarzyna Bulek;Caini Liu

Frequent Co-Authors

Xiaoxia Li
Xiaoxia Li Cleveland Clinic Lerner College of Medicine
Bing Su
Bing Su Shanghai Jiao Tong University
James H. Finke
James H. Finke Cleveland Clinic Lerner College of Medicine
Robert L. Fairchild
Robert L. Fairchild Cleveland Clinic Lerner College of Medicine
Paul E. DiCorleto
Paul E. DiCorleto Kent State University
Ganes C. Sen
Ganes C. Sen Case Western Reserve University
Paul L. Fox
Paul L. Fox Cleveland Clinic Lerner College of Medicine
Timothy S. Kern
Timothy S. Kern University of California, Irvine
Sergei A. Nedospasov
Sergei A. Nedospasov Lomonosov Moscow State University
Guy M. Chisolm
Guy M. Chisolm Cleveland Clinic

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