Jeanne A. Stuckey

Overview

Best Publications

• Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

  Ke Ding;Yipin Lu;Zaneta Nikolovska-Coleska;Guoping Wang

  844
  Citations

• Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors

  Ke Ding;Yipin Lu;Zaneta Nikolovska-Coleska;Su Qiu

  777
  Citations

• Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization

  Zaneta Nikolovska-Coleska;Renxiao Wang;Xueliang Fang;Hongguang Pan

  672
  Citations

• A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

  Longchuan Bai;Haibin Zhou;Renqi Xu;Yujun Zhao

  579
  Citations

• Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate

  Jeanne A. Stuckey;Heidi L. Schubert;Eric B. Fauman;Zhong Yin Zhang;Zhong Yin Zhang

  521
  Citations

• Form and Function in Protein Dephosphorylation

  John M Denu;Jeanne A Stuckey;Mark A Saper;Jack E Dixon

  485
  Citations

• Hydrolytic catalysis and structural stabilization in a designed metalloprotein

  Melissa L. Zastrow;Anna F. A. Peacock;Anna F. A. Peacock;Jeanne A. Stuckey;Vincent L. Pecoraro

  384
  Citations

• Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.

  Guoping Wang;Zaneta Nikolovska-Coleska;Chao Yie Yang;Renxiao Wang

  382
  Citations

• Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer.

  Xin Han;Chao Wang;Chong Qin;Weiguo Xiang

  373
  Citations

• Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis.

  Neil Richards;Philip Schaner;Arturo Diaz;Jeanne Stuckey

  346
  Citations

• SAR405838: An optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression

  Shaomeng Wang;Wei Sun;Yujun Zhao;Donna McEachern

  314
  Citations

• Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

  Chong Qin;Yang Hu;Bing Zhou;Ester Fernandez-Salas

  307
  Citations

• Crystal structure of a phospholipase D family member.

  Jeanne A. Stuckey;Jack E. Dixon

  299
  Citations

• Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.

  Haiying Sun;Zaneta Nikolovska-Coleska;Jianfeng Lu;Jennifer L. Meagher

  290
  Citations

• Expression, purification, and physicochemical characterization of a recombinant Yersinia protein tyrosine phosphatase.

  Zhong-Yin Zhang;J. C. Clemens;H. L. Schubert;J. A. Stuckey

  287
  Citations

• Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER).

  Jiantao Hu;Biao Hu;Mingliang Wang;Fuming Xu

  245
  Citations

• A unique carbohydrate binding domain targets the lafora disease phosphatase to glycogen.

  Jianyong Wang;Jeanne A. Stuckey;Matthew J. Wishart;Jack E. Dixon

  240
  Citations

• SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

  Jianfeng Lu;Longchuan Bai;Haiying Sun;Zaneta Nikolovska-Coleska

  240
  Citations

• D3R Grand Challenge 2015: Evaluation of Protein-Ligand Pose and Affinity Predictions

  Symon Gathiaka;Shuai Liu;Michael Chiu;Huanwang Yang

  222
  Citations

• The Cys(X)5Arg Catalytic Motif in Phosphoester Hydrolysis

  Zhong Yin Zhang;Yuan Wang;Li Wu;Li Wu;Eric B. Fauman

  222
  Citations