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D-Index & Metrics

Biology and Biochemistry

D-Index
93
Citations
28086
World Ranking
2129
National Ranking
1152

Overview

William C. Merrick is affiliated with Case Western Reserve University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a strong emphasis on molecular biology within these fields.

The scientist's work extensively covers topics related to RNA and protein synthesis mechanisms, RNA modifications and cancer, and RNA research and splicing. Additional research interests include RNA regulation and disease, endoplasmic reticulum stress and disease, RNA interference and gene delivery, as well as the biological activities of phytochemical compounds.

William C. Merrick has published in multiple scientific journals, reflecting their research scope. Frequent publication venues include:

  • Cell Reports
  • Molecular Cell
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • International Journal of Molecular Sciences

Their coauthors frequently include Maria Hatzoglou, Anton A. Komar, Bo-Jhih Guan, Raul Jobava, and Dawid Krokowski, with multiple collaborations documented with each.

Among recent publications by William C. Merrick are the following works:

  • eIF4G has intrinsic G-quadruplex binding activity that is required for tiRNA function, 2020, Nucleic Acids Research
  • Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F, 2020, Cell Reports
  • A Retrospective on eIF2A-and Not the Alpha Subunit of eIF2, 2020, International Journal of Molecular Sciences
  • eIF2A-knockout mice reveal decreased life span and metabolic syndrome, 2021, The FASEB Journal
  • Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress, 2021, Molecular Cell

Best Publications

  • Complete amino acid analysis of proteins from a single hydrolysate.

    R J Simpson;M R Neuberger;T Y Liu

  • Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

    Tilman Schneider-Poetsch;Jianhua Ju;Daniel E Eyler;Yongjun Dang

  • Mechanism and regulation of eukaryotic protein synthesis.

    W C Merrick

  • Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.

    Florence Rozen;Isaac Edery;Karen Meerovitch;Thomas E. Dever

  • GTP-binding domain: three consensus sequence elements with distinct spacing

    Thomas E. Dever;Manuel J. Glynias;William C. Merrick

  • MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F

    Géraldine Mathonnet;Marc R. Fabian;Yuri V. Svitkin;Armen Parsyan

  • The Transformation Suppressor Pdcd4 Is a Novel Eukaryotic Translation Initiation Factor 4A Binding Protein That Inhibits Translation

    Hsin Sheng Yang;Aaron P. Jansen;Anton A. Komar;Xiaojing Zheng

  • ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors

    B K Ray;T G Lawson;J C Kramer;M H Cladaras

  • Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.

    Arnim Pause;Nathalie Méthot;Yuri Svitkin;William C. Merrick

  • New initiation factor activity required for globin mRNA translation.

    J A Grifo;S M Tahara;M A Morgan;A J Shatkin

  • A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA

    Nahum Sonenberg;Maureen A. Morgan;William C. Merrick;Aaron J. Shatkin

  • Modulation of the Helicase Activity of eIF4A by eIF4B, eIF4H, and eIF4F

    George W. Rogers;Nancy J. Richter;Walt F. Lima;William C. Merrick

  • Biochemical and Kinetic Characterization of the RNA Helicase Activity of Eukaryotic Initiation Factor 4A

    George W. Rogers;Nancy J. Richter;William C. Merrick

  • Eukaryotic protein elongation factors.

    Bent Riis;Suresh I.S. Rattan;Brian F.C. Clark;William C. Merrick

  • mRNA helicases:the tacticians of translational control

    Armen Parsyan;Yuri Svitkin;David Shahbazian;Christos Gkogkas

  • eIF4A: the godfather of the DEAD box helicases.

    George W Rogers;Anton A Komar;William C Merrick

  • Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron

    Kazuhiro Honda;Mark A. Smith;Xiongwei Zhu;Diane Baus

  • 2 The Pathway and Mechanism of Eukaryotic Protein Synthesis

    William C. Merrick;John W.B. Hershey

  • Cap-dependent and cap-independent translation in eukaryotic systems

    William C Merrick

  • 2 The Pathway and Mechanism of Initiation of Protein Synthesis

    John W. B. Hershey;William C. Merrick

Frequent Co-Authors

Thomas E. Dever
Thomas E. Dever National Institutes of Health
Anton A. Komar
Anton A. Komar Cleveland State University
Maria Hatzoglou
Maria Hatzoglou Case Western Reserve University
John W. B. Hershey
John W. B. Hershey University of California, Davis
Nahum Sonenberg
Nahum Sonenberg McGill University
Ganes C. Sen
Ganes C. Sen Case Western Reserve University
Brian Safer
Brian Safer National Institutes of Health
Jerry Pelletier
Jerry Pelletier McGill University
Ivan N. Shatsky
Ivan N. Shatsky Lomonosov Moscow State University
Antonis E. Koromilas
Antonis E. Koromilas McGill University

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