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Molecular Biology

D-Index
75
Citations
25376
World Ranking
1179
National Ranking
609

Overview

Tatyana V. Pestova is affiliated with SUNY Downstate Medical Center in the United States. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with a significant focus on molecular biology and its intersections with medicine.

Their work often addresses mechanisms involving RNA and protein synthesis, viral infections and immunology, RNA modifications related to cancer, and gene regulation processes like splicing and interference. Subfields of study include molecular biology, cardiology and cardiovascular medicine, plant science, oncology, and infectious diseases.

Frequent topics covered in their research are:

  • RNA and protein synthesis mechanisms
  • Viral infections and immunology research
  • RNA modifications and cancer
  • RNA research and splicing
  • Plant virus research studies
  • RNA interference and gene delivery
  • Viral gastroenteritis research and epidemiology

Tatyana V. Pestova has contributed to several publication venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • Viruses
  • Genes & Development
  • RNA

Among recent papers, notable examples include:

  • Extraction of mRNA from Stalled Ribosomes by the Ski Complex, 2020, Molecular Cell
  • Dissemination of Internal Ribosomal Entry Sites (IRES) Between Viruses by Horizontal Gene Transfer, 2020, Viruses
  • Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES, 2022, The EMBO Journal
  • The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism, 2020, Cell Reports
  • Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC, 2024, Nucleic Acids Research

The scientist also collaborates frequently with a network of researchers including Christopher U.T. Hellen, Irina S. Abaeva, Yani Arhab, Zuben P. Brown, and Joachim Frank, reflecting multidisciplinary cooperation within their fields.

Their research contributions encompass a broad spectrum of molecular and cellular mechanisms, especially focusing on translation initiation, ribosome function, and viral RNA interactions, supporting ongoing inquiry into RNA biology and viral pathogenesis.

Best Publications

  • The mechanism of eukaryotic translation initiation and principles of its regulation

    Richard J. Jackson;Christopher U. T. Hellen;Tatyana V. Pestova

  • 5′ UTR m6A Promotes Cap-Independent Translation

    Kate D. Meyer;Deepak P. Patil;Jun Zhou;Alexandra Zinoviev

  • Molecular mechanisms of translation initiation in eukaryotes.

    Tatyana V. Pestova;Victoria G. Kolupaeva;Ivan B. Lomakin;Evgeny V. Pilipenko

  • A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initation of hepatitis C and classical swine fever virus RNAs

    Tatyana V. Pestova;Ivan N. Shatsky;Simon P. Fletcher;Richard J. Jackson

  • The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection.

    Tatyana V. Pestova;Victoria G. Kolupaeva

  • Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry

    T. V. Pestova;C. U. T. Hellen;I. N. Shatsky

  • Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons

    Tatyana V. Pestova;Tatyana V. Pestova;Sergei I. Borukhov;Christopher U. T. Hellen

  • The joining of ribosomal subunits in eukaryotes requires eIF5B

    Tatyana V. Pestova;Ivan B. Lomakin;Joon H. Lee;Sang Ki Choi

  • Initiation of protein synthesis from the A site of the ribosome.

    Joan E Wilson;Tatyana V Pestova;Christopher U.T Hellen;Peter Sarnow

  • Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes.

    T. V. Pestova;I. N. Shatsky;C. U. T. Hellen

  • A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein.

    Christopher U. T. Hellen;Gary W. Witherell;Michael Schmid;Sang Hoon Shin

  • The Role of ABCE1 in Eukaryotic Posttermination Ribosomal Recycling

    Andrey V. Pisarev;Maxim A. Skabkin;Vera P. Pisareva;Olga V. Skabkina

  • In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3.

    Elena Z. Alkalaeva;Andrey V. Pisarev;Lyudmila Y. Frolova;Lev L. Kisselev

  • A cell cycle-dependent protein serves as a template-specific translation initiation factor.

    Evgeny V. Pilipenko;Tatyana V. Pestova;Victoria G. Kolupaeva;Elena V. Khitrina

  • Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.

    Vera P Pisareva;Maxim A Skabkin;Christopher U T Hellen;Tatyana V Pestova

  • Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs.

    Daria V. Sizova;Victoria G. Kolupaeva;Victoria G. Kolupaeva;Tatyana V. Pestova;Tatyana V. Pestova;Ivan N. Shatsky

  • Translation elongation after assembly of ribosomes on the Cricket paralysis virus internal ribosomal entry site without initiation factors or initiator tRNA.

    Tatyana V. Pestova;Christopher U.T. Hellen

  • Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of eIF2-bound GTP

    Anett Unbehaun;Sergei I. Borukhov;Christopher U.T. Hellen;Tatyana V. Pestova

  • Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region.

    Shigenobu Morino;Hiroaki Imataka;Yuri V. Svitkin;Tatyana V. Pestova

  • Recycling of eukaryotic posttermination ribosomal complexes.

    Andrey V. Pisarev;Christopher U.T. Hellen;Tatyana V. Pestova;Tatyana V. Pestova

Frequent Co-Authors

Christopher U.T. Hellen
Christopher U.T. Hellen SUNY Downstate Medical Center
Ivan N. Shatsky
Ivan N. Shatsky Lomonosov Moscow State University
Joachim Frank
Joachim Frank Columbia University
Vadim I. Agol
Vadim I. Agol Lomonosov Moscow State University
Anton A. Komar
Anton A. Komar Cleveland State University
Gerhard Wagner
Gerhard Wagner Harvard University
Eckard Wimmer
Eckard Wimmer Stony Brook University
Nahum Sonenberg
Nahum Sonenberg McGill University
Yuri V. Svitkin
Yuri V. Svitkin McGill University
William C. Merrick
William C. Merrick Case Western Reserve University

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