Jon R. Lorsch

Overview

Best Publications

• The molecular mechanics of eukaryotic translation

  Lee D. Kapp;Jon R. Lorsch

  780
  Citations

• The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges

  Alan G. Hinnebusch;Jon R. Lorsch

  621
  Citations

• A mechanistic overview of translation initiation in eukaryotes

  Colin Echeverría Aitken;Jon R Lorsch

  529
  Citations

• The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome.

  Lori A. Passmore;T. Martin Schmeing;David Maag;Drew J. Applefield

  415
  Citations

• In vitro evolution of new ribozymes with polynucleotide kinase activity

  Jon R. Lorsch;Jack W. Szostak

  402
  Citations

• Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation.

  Mikkel A. Algire;David Maag;Jon R. Lorsch

  334
  Citations

• In vitro selection of RNA aptamers specific for cyanocobalamin

  Jon R. Lorsch;Jack W. Szostak

  311
  Citations

• The DEAD Box Protein eIF4A. 1. A Minimal Kinetic and Thermodynamic Framework Reveals Coupled Binding of RNA and Nucleotide

  Jon R. Lorsch;Daniel Herschlag

  286
  Citations

• A Conformational Change in the Eukaryotic Translation Preinitiation Complex and Release of eIF1 Signal Recognition of the Start Codon

  David Maag;Christie A. Fekete;Zygmunt Gryczynski;Jon R. Lorsch

  261
  Citations

• The DEAD Box Protein eIF4A. 2. A Cycle of Nucleotide and RNA-Dependent Conformational Changes†

  Jon R. Lorsch;Daniel Herschlag

  222
  Citations

• Fixing problems with cell lines

  Jon R. Lorsch;Francis S. Collins;Jennifer Lippincott-Schwartz

  217
  Citations

• Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex

  Tanweer Hussain;José Luis Llácer;Israel S. Fernández;Antonio Munoz;Antonio Munoz

  215
  Citations

• Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo

  Yuen Nei Cheung;David Maag;Sarah F. Mitchell;Christie A. Fekete

  213
  Citations

• Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

  Jose L. Llácer;Tanweer Hussain;Laura Marler;Colin Echeverría Aitken

  211
  Citations

• RNA Chaperones Exist and DEAD Box Proteins Get a Life

  Jon R. Lorsch

  208
  Citations

• Ribozyme catalysis: not different, just worse

  Jennifer A Doudna;Jon R Lorsch

  189
  Citations

• GTP-dependent Recognition of the Methionine Moiety on Initiator tRNA by Translation Factor eIF2

  Lee D. Kapp;Jon R. Lorsch

  185
  Citations

• Development and characterization of a reconstituted yeast translation initiation system.

  Mikkel A. Algire;David Maag;Peter Savio;Michael G. Acker

  184
  Citations

• RECONSTITUTION OF YEAST TRANSLATION INITIATION

  Michael G. Acker;Sarah E. Kolitz;Sarah F. Mitchell;Jagpreet S. Nanda

  176
  Citations

• The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway

  Sarah F. Mitchell;Sarah E. Walker;Mikkel A. Algire;Eun Hee Park

  175
  Citations