World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
43
Citations
7312
World Ranking
2976
National Ranking
231

Overview

Graham D. Pavitt is affiliated with the University of Manchester in the United Kingdom. Their research is situated primarily within the domain of Biochemistry, Genetics, and Molecular Biology. Within this broad field, they focus on subfields including Molecular Biology, Cell Biology, Immunology, and Radiology, Nuclear Medicine and Imaging.

The main topics covered in their work include:

  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • RNA modifications and cancer
  • RNA regulation and disease
  • Biochemical and Molecular Research
  • Endoplasmic Reticulum Stress and Disease
  • Polyamine Metabolism and Applications

The scientist has contributed notable papers, such as:

  • "Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine" (2021) published in Nature Communications
  • "GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity" (2021) published in iScience
  • "Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs" (2023) published in Nucleic Acids Research
  • "Cytosolic aspartate aminotransferase moonlights as a ribosome-binding modulator of Gcn2 activity during oxidative stress" (2022) published in eLife
  • "Translation factor and RNA binding protein mRNA interactomes support broader RNA regulons for posttranscriptional control" (2023) published in Journal of Biological Chemistry

Frequent collaboration is a feature of their work, with common coauthors including:

  • Martin D. Jennings
  • Christopher J. Kershaw
  • Robert A. Crawford
  • Mark Ashe
  • Simon J. Hubbard

Their research outputs have appeared repeatedly in a set of venues including bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, iScience, Nucleic Acids Research, and eLife.

Best Publications

  • Global Translational Responses to Oxidative Stress Impact upon Multiple Levels of Protein Synthesis

    Daniel Shenton;Julia B. Smirnova;Julian N. Selley;Kathleen Carroll

  • Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation

    Thanuja Krishnamoorthy;Graham D. Pavitt;Fan Zhang;Thomas E. Dever

  • The chromatin-associated protein H-NS interacts with curved DNA to influence DNA topology and gene expression.

    Thomas A. Owen-Hughes;Graham D. Pavitt;Diogenes S. Santos;Julie M. Sidebotham

  • Histone-like protein H1 (H-NS), DNA supercoiling, and gene expression in bacteria

    Christopher S.J. Hulton;Alexander Seirafi;Jay C.D. Hinton;Julie M. Sidebotham

  • eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine–nucleotide exchange

    Graham D. Pavitt;Kolluru V.A. Ramaiah;Kolluru V.A. Ramaiah;Scot R. Kimball;Alan G. Hinnebusch

  • Protein Synthesis Initiation in Eukaryotic Cells.

    William C. Merrick;Graham D. Pavitt

  • Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.

    Katsura Asano;Thanuja Krishnamoorthy;Lon Phan;Graham D. Pavitt

  • Protein H1: a role for chromatin structure in the regulation of bacterial gene expression and virulence?

    C. F. Higgins;J. C. D. Hinton;C. S. J. Hulton;T. Owen-Hughes

  • Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.

    Paola Falletta;Luis Sanchez-del-Campo;Jagat Chauhan;Maike Effern

  • New Insights into Translational Regulation in the Endoplasmic Reticulum Unfolded Protein Response

    Graham D. Pavitt;David Ron

  • eIF2B, a mediator of general and gene-specific translational control

    G.D. Pavitt

  • Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

    Graham D. Pavitt;Weimin Yang;Andalan G. Hinnebusch

  • Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.

    Thomas E Dever;Terri Goss Kinzy;Graham D Pavitt

  • The structural basis of translational control by eIF2 phosphorylation

    Tomas Adomavicius;Margherita Guaita;Yu Zhou;Martin D. Jennings

  • Expression and mutational analysis of the nucleoid‐associated protein H‐NS of Salmonella typhimurium

    Jay C. D. Hinton;Diogenes S. Santos;Alexander Seirafi;Christopher S. J. Hulton

  • Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha- and delta-subunits of eiF2b.

    Scot R. Kimball;John R. Fabian;Graham D. Pavitt;Alan G. Hinnebusch

  • Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity.

    Jonathan P. Richardson;Sarah S. Mohammad;Graham D. Pavitt

  • Identification of Domains and Residues within the ɛ Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2Bɛ) Required for Guanine Nucleotide Exchange Reveals a Novel Activation Function Promoted by eIF2B Complex Formation

    Edith Gomez;Graham D. Pavitt

  • Characterization of the minimal catalytic domain within eIF2B: the guanine‐nucleotide exchange factor for translation initiation

    Edith Gomez;Sarah S. Mohammad;Graham D. Pavitt

  • eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation

    Martin D. Jennings;Graham D. Pavitt

Frequent Co-Authors

Simon J. Hubbard
Simon J. Hubbard Manchester Academic Health Science Centre
Chris M. Grant
Chris M. Grant University of Manchester
Paul F. G. Sims
Paul F. G. Sims University of Manchester
Alan G. Hinnebusch
Alan G. Hinnebusch National Institutes of Health
Christopher F. Higgins
Christopher F. Higgins Hammersmith Hospital
Yanick J. Crow
Yanick J. Crow Université Paris Cité
Jay C. D. Hinton
Jay C. D. Hinton University of Liverpool
Jeanne Amiel
Jeanne Amiel Université Paris Cité

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