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Molecular Biology
UK
2026
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Genetics and Molecular Biology
UK
2024

D-Index & Metrics

Molecular Biology

D-Index
140
Citations
115594
World Ranking
124
National Ranking
7

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United Kingdom Leader Award
  • 2025 - Research.com Molecular Biology in United Kingdom Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2023 - Research.com Molecular Biology in United Kingdom Leader Award
  • 2014 - Fellow of the Royal Society, United Kingdom

Overview

David Ron is affiliated with the University of Cambridge in the United Kingdom. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with significant contributions in the subfields of Molecular Biology, Cell Biology, Epidemiology, Endocrinology, and Surgery.

The scientist's research addresses a variety of topics including:

  • Endoplasmic Reticulum Stress and Disease
  • RNA regulation and disease
  • Autophagy in Disease and Therapy
  • RNA Research and Splicing
  • Heat shock proteins research
  • Pancreatic function and diabetes
  • Enzyme Structure and Function

Among their recent publications are:

  • Pharmacological targeting of endoplasmic reticulum stress in disease, 2021, Nature Reviews Drug Discovery
  • ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B, 2020, Molecular Cell
  • Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes, 2020, eLife
  • ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth, 2020, UNC Libraries
  • Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers, 2021, Cell Reports

David Ron frequently collaborates with several researchers including Heather P. Harding, Luke A. Perera, Yahui Yan, A. Ordóñez, and Ginto George.

The scientist often publishes in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Molecular Cell
  • Proceedings of the National Academy of Sciences
  • Apollo (University of Cambridge)

David Ron was recognized as a Fellow of the Royal Society, United Kingdom in 2014.

Best Publications

  • Signal integration in the endoplasmic reticulum unfolded protein response

    David Ron;Peter Walter

  • The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

    Peter Walter;David Ron

  • Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

    Heather P. Harding;Yuhong Zhang;David Ron

  • An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

    Heather P. Harding;Yuhong Zhang;Huiquing Zeng;Isabel Novoa

  • Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

    Heather P Harding;Isabel Novoa;Yuhong Zhang;Huiqing Zeng

  • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

    Fumihiko Urano;Xiao Zhong Wang;Anne Bertolotti;Yuhong Zhang

  • Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

    Anne Bertolotti;Yuhong Zhang;Linda M. Hendershot;Linda M. Hendershot;Heather P. Harding

  • IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

    Marcella Calfon;Huiqing Zeng;Fumihiko Urano;Jeffery H Till

  • Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress.

    Ira Tabas;David Ron

  • CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

    Helene Zinszner;Masahiko Kuroda;XiaoZhong Wang;Nikoleta Batchvarova

  • Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

    Heather P Harding;Yuhong Zhang;Anne Bertolotti;Huiqing Zeng

  • CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

    Stefan J. Marciniak;Chi Y. Yun;Seiichi Oyadomari;Isabel Novoa

  • Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

    J. Nangalia;C.E. Massie;E.J. Baxter;F.L. Nice

  • A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

    Michael Boyce;Kevin F. Bryant;Céline Jousse;Kai Long

  • CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

    David Ron;Joel F. Habener

  • Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

    Isabel Novoa;Huiqing Zeng;Heather P. Harding;David Ron

  • GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

    David H. Munn;Madhav D. Sharma;Babak Baban;Heather P. Harding

  • Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

    Heather P. Harding;Huiqing Zeng;Yuhong Zhang;Rivka Jungries

  • Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

    Phoebe D. Lu;Heather P. Harding;David Ron

  • Dynamic interaction of BiP and ER stress transducers in the unfolded

    Anne Bertolotti;Yuhong Zhang;Linda M. Hendershot;David Ron

Frequent Co-Authors

Heather P. Harding
Heather P. Harding University of Cambridge
Fumihiko Urano
Fumihiko Urano Washington University in St. Louis
Joel F. Habener
Joel F. Habener Harvard University
Randal J. Kaufman
Randal J. Kaufman Sanford Burnham Prebys Medical Discovery Institute
Randy J. Read
Randy J. Read University of Cambridge
Linda M. Hendershot
Linda M. Hendershot St. Jude Children's Research Hospital
Masahiko Kuroda
Masahiko Kuroda Tokyo Medical University
Allan R. Brasier
Allan R. Brasier University of Wisconsin–Madison
Thomas A. Neubert
Thomas A. Neubert New York University
Ira Tabas
Ira Tabas Columbia University

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