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Neuroscience
USA
2026

D-Index & Metrics

Neuroscience

D-Index
145
Citations
84920
World Ranking
171
National Ranking
109

Research.com Recognitions

  • 2026 - Research.com Neuroscience in United States Leader Award
  • 2025 - Research.com Neuroscience in United States Leader Award
  • 2007 - Fellow of the Royal Society, United Kingdom
  • 2004 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Morgan Sheng is affiliated with the Broad Institute in the United States. Their research focuses primarily on the intersection of molecular biology, neuroscience, and neurodegenerative diseases. The scientist has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, and Neuroscience with a significant emphasis on subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Genetics, and Immunology.

The main topics explored in their work include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Genetics and Neurodevelopmental Disorders
  • Receptor Mechanisms and Signaling
  • Immune cells in cancer
  • Alzheimer's disease research and treatments
  • Neurogenesis and neuroplasticity mechanisms

Recent notable papers by Morgan Sheng cover a range of studies primarily targeting Alzheimer's disease and neurodegeneration. Selected works include:

  • "Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology," 2021, Neuron
  • "Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models," 2022, Nature Aging
  • "Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model," 2020, Journal of Neuroscience
  • "Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease," 2023, Nature Neuroscience
  • "Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination," 2021, Cell Reports

Frequent co-authors with whom Morgan Sheng has collaborated include:

  • Zohreh Farsi
  • Borislav Dejanovic
  • Sameer Aryal
  • Steven A. Carr
  • Bryan J. Song

Morgan Sheng has contributed publications in several venues, with a significant number appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Cell Reports
  • Zenodo (CERN European Organization for Nuclear Research)
  • Neuron

Recognitions awarded to Morgan Sheng include:

  • Fellow of the Royal Society, United Kingdom, 2007
  • Fellow of the American Association for the Advancement of Science (AAAS), 2004
  • Fellow of The Academy of Medical Sciences, United Kingdom

Best Publications

  • The regulation and function of c-fos and other immediate early genes in the nervous system.

    Morgan Sheng;Michael E. Greenberg

  • PDZ domain proteins of synapses

    Eunjoon Kim;Morgan Sheng

  • CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases

    Morgan Sheng;Margaret A. Thompson;Michael E. Greenberg

  • Microglia in Alzheimer's disease.

    David V. Hansen;Jesse E. Hanson;Morgan Sheng

  • The Importance of Dendritic Mitochondria in the Morphogenesis and Plasticity of Spines and Synapses

    Zheng Li;Ken Ichi Okamoto;Yasunori Hayashi;Morgan Sheng

  • Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

    Morgan Sheng;Jennifer Cummings;Leslie Ann Roldan;Yuh Nung Jan

  • PDZ Domains and the Organization of Supramolecular Complexes

    Morgan Sheng;Carlo Sala

  • Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.

    Declan A. Doyle;Alice Lee;John Lewis;Eunjoon Kim

  • Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity

    Lidong Liu;Tak Pan Wong;Mario F. Pozza;Kurt Lingenhoehl

  • Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB.

    Morgan Sheng;Grant McFadden;Michael E. Greenberg

  • Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins

    Jian Cheng Tu;Bo Xiao;Scott Naisbitt;Scott Naisbitt;Joseph P. Yuan

  • Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin

    Scott Naisbitt;Eunjoon Kim;Jian Cheng Tu;Bo Xiao

  • The postsynaptic architecture of excitatory synapses: a more quantitative view.

    Morgan Sheng;Casper C. Hoogenraad

  • Dendritic spines: structure, dynamics and regulation.

    Heike Hering;Morgan Sheng

  • TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

    Felix L. Yeh;Yuanyuan Wang;Irene Tom;Lino C. Gonzalez

  • Tbr1 Regulates Differentiation of the Preplate and Layer 6

    Robert F. Hevner;Limin Shi;Nicholas J Justice;Yi Ping Hsueh

  • Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases

    M Niethammer;E Kim;M Sheng

  • SynGO : An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

    Frank Koopmans;Pim van Nierop;Maria Andres-Alonso;Andrea Byrnes

  • PDZ domains: structural modules for protein complex assembly.

    Albert Y. Hung;Morgan Sheng

  • Postsynaptic signaling and plasticity mechanisms

    Morgan Sheng;Myung Jong Kim

  • Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

    Dieter Edbauer;Joel R. Neilson;Kelly A. Foster;Chi-Fong Wang

  • Molecular mechanisms of dendritic spine morphogenesis

    Tomoko Tada;Morgan Sheng

  • Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization

    Heng-Ye Man;Jerry W. Lin;William H. Ju;Gholamreza Ahmadian

Frequent Co-Authors

Eunjoon Kim
Eunjoon Kim Korea Advanced Institute of Science and Technology
Richard J. Weinberg
Richard J. Weinberg University of North Carolina at Chapel Hill
Yu Tian Wang
Yu Tian Wang University of British Columbia
Juli G. Valtschanoff
Juli G. Valtschanoff University of North Carolina at Chapel Hill
Michael E. Greenberg
Michael E. Greenberg Harvard University
Kwangwook Cho
Kwangwook Cho King's College London
Lily Yeh Jan
Lily Yeh Jan University of California, San Francisco
Ann Marie Craig
Ann Marie Craig University of British Columbia
Graham L. Collingridge
Graham L. Collingridge Lunenfeld-Tanenbaum Research Institute
Bernardo L. Sabatini
Bernardo L. Sabatini Harvard Medical School

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