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Biology and Biochemistry

D-Index
89
Citations
66429
World Ranking
2489
National Ranking
176

Overview

Heather P. Harding is affiliated with the University of Cambridge in the United Kingdom and specializes in Biochemistry, Genetics, and Molecular Biology. Within this broad domain, their research focuses on molecular biology, cell biology, epidemiology, surgery, and genetics. The main topics explored in their work include endoplasmic reticulum stress and disease, RNA regulation and disease, RNA research and splicing, autophagy in disease and therapy, pancreatic function and diabetes, CRISPR and genetic engineering, as well as cancer, hypoxia, and metabolism.

They have published extensively, with a notable presence in journals such as bioRxiv (Cold Spring Harbor Laboratory), eLife, Molecular Cell, The EMBO Journal, and EMBO Molecular Medicine. The majority of their papers are concentrated in the field of molecular biology and cell biology, reflecting a consistent research trajectory in these areas.

Key recent papers authored or co-authored by Heather P. Harding include:

  • "ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B" (2020, Molecular Cell)
  • "ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth" (2020, UNC Libraries)
  • "Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers" (2021, Cell Reports)
  • "The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells" (2023, The EMBO Journal)
  • "Higher-order phosphatase-substrate contacts terminate the integrated stress response" (2021, Nature Structural & Molecular Biology)

Throughout their career, Harding has collaborated frequently with several researchers, including David Ron, A. Ordóñez, Ginto George, Alisa Zyryanova, and Yahui Yan. These collaborations underline a network of research partnerships contributing to advancements in their areas of study.

Best Publications

  • Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

    Heather P. Harding;Yuhong Zhang;David Ron

  • An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

    Heather P. Harding;Yuhong Zhang;Huiquing Zeng;Isabel Novoa

  • Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

    Heather P Harding;Isabel Novoa;Yuhong Zhang;Huiqing Zeng

  • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

    Fumihiko Urano;Xiao Zhong Wang;Anne Bertolotti;Yuhong Zhang

  • Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

    Anne Bertolotti;Yuhong Zhang;Linda M. Hendershot;Linda M. Hendershot;Heather P. Harding

  • IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

    Marcella Calfon;Huiqing Zeng;Fumihiko Urano;Jeffery H Till

  • Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

    Heather P Harding;Yuhong Zhang;Anne Bertolotti;Huiqing Zeng

  • CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

    Stefan J. Marciniak;Chi Y. Yun;Seiichi Oyadomari;Isabel Novoa

  • Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

    J. Nangalia;C.E. Massie;E.J. Baxter;F.L. Nice

  • A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

    Michael Boyce;Kevin F. Bryant;Céline Jousse;Kai Long

  • Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

    Isabel Novoa;Huiqing Zeng;Heather P. Harding;David Ron

  • GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

    David H. Munn;Madhav D. Sharma;Babak Baban;Heather P. Harding

  • Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

    Heather P. Harding;Huiqing Zeng;Yuhong Zhang;Rivka Jungries

  • Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

    Phoebe D. Lu;Heather P. Harding;David Ron

  • Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

    Heather P Harding;Marcella Calfon;Fumihiko Urano;Isabel Novoa

  • The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

    Bo Feng;Pin Mei Yao;Yankun Li;Cecilia M. Devlin

  • Targeting the unfolded protein response in disease

    Claudio Hetz;Eric Chevet;Heather P. Harding

  • Cloning of mammalian Ire1 reveals diversity in the ER stress responses.

    Xiao Zhong Wang;Heather P. Harding;Yuhong Zhang;Ethel M. Jolicoeur

  • Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

    Ker Yu;William Bayona;Caleb B. Kallen;Heather P. Harding

  • ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

    Meixia Bi;Christine Naczki;Marianne Koritzinsky;Diane Fels

Frequent Co-Authors

David Ron
David Ron University of Cambridge
Randal J. Kaufman
Randal J. Kaufman Sanford Burnham Prebys Medical Discovery Institute
Mitchell A. Lazar
Mitchell A. Lazar University of Pennsylvania
Leopold Parts
Leopold Parts Wellcome Sanger Institute
Stephen O'Rahilly
Stephen O'Rahilly University of Cambridge
Fumihiko Urano
Fumihiko Urano Washington University in St. Louis
Brian Popko
Brian Popko Northwestern University
Wayne I. Lencer
Wayne I. Lencer Harvard University
Jonathan C. Kagan
Jonathan C. Kagan Boston Children's Hospital
Laurie H. Glimcher
Laurie H. Glimcher Harvard University

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