D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 84 Citations 56,817 141 World Ranking 2063 National Ranking 141

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • DNA
  • Amino acid

Heather P. Harding mainly investigates Unfolded protein response, Endoplasmic reticulum, Cell biology, Signal transduction and Integrated stress response. When carried out as part of a general Unfolded protein response research project, her work on EIF2AK3 is frequently linked to work in PERK inhibitors, therefore connecting diverse disciplines of study. Her studies examine the connections between Endoplasmic reticulum and genetics, as well as such issues in Phosphorylation, with regards to Kinase.

Her Cell biology study integrates concerns from other disciplines, such as Apoptosis, Regulation of gene expression and Chaperone Gene. Her studies deal with areas such as X-Box Binding Protein 1 and Protein folding as well as Signal transduction. Her work in Integrated stress response covers topics such as Protein biosynthesis which are related to areas like ER oxidoreductin and Amino acid.

Her most cited work include:

  • Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase (2508 citations)
  • Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells (2453 citations)
  • An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress (2298 citations)

What are the main themes of her work throughout her whole career to date?

Her main research concerns Cell biology, Unfolded protein response, Endoplasmic reticulum, Biochemistry and Molecular biology. Heather P. Harding is studying ATF6, which is a component of Cell biology. The various areas that Heather P. Harding examines in her Unfolded protein response study include Integrated stress response, XBP1, Signal transduction, Phosphorylation and Kinase.

Her work on Protein disulfide-isomerase as part of general Endoplasmic reticulum study is frequently linked to EIF-2 kinase, bridging the gap between disciplines. Her Biochemistry research focuses on Biophysics and how it relates to Plasma protein binding. The concepts of her Molecular biology study are interwoven with issues in RNA, Transcription factor, Transcription Factor CHOP, Orphan receptor and Messenger RNA.

She most often published in these fields:

  • Cell biology (52.70%)
  • Unfolded protein response (50.00%)
  • Endoplasmic reticulum (48.65%)

What were the highlights of her more recent work (between 2013-2021)?

  • Cell biology (52.70%)
  • Endoplasmic reticulum (48.65%)
  • Unfolded protein response (50.00%)

In recent papers she was focusing on the following fields of study:

Her scientific interests lie mostly in Cell biology, Endoplasmic reticulum, Unfolded protein response, Integrated stress response and eIF2B. Her work deals with themes such as Experimental autoimmune encephalomyelitis and Receptor, which intersect with Cell biology. The Protein disulfide-isomerase research Heather P. Harding does as part of her general Endoplasmic reticulum study is frequently linked to other disciplines of science, such as Glutathione, therefore creating a link between diverse domains of science.

Her Unfolded protein response study deals with the bigger picture of Biochemistry. In her research on the topic of Integrated stress response, Eukaryotic translation is strongly related with Initiation factor. Her studies in eIF2B integrate themes in fields like Phenotype, Guanine nucleotide exchange factor, eIF2 and Pathology.

Between 2013 and 2021, her most popular works were:

  • Predicting the mutations generated by repair of Cas9-induced double-strand breaks (182 citations)
  • Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. (166 citations)
  • Mutations in a translation initiation factor identify the target of a memory-enhancing compound (151 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Amino acid

Her primary scientific interests are in Unfolded protein response, Cell biology, Endoplasmic reticulum, Integrated stress response and Protein folding. Her Unfolded protein response research is multidisciplinary, relying on both Immunology and Dysbiosis. Her Endoplasmic reticulum study integrates concerns from other disciplines, such as Heat shock protein, Repressor, Co-chaperone and Transmembrane protein.

Her Integrated stress response research also works with subjects such as

  • eIF2B and related Initiation factor, Eukaryotic translation, Nucleotide exchange factor, Regulatory site and Molecular biology,
  • Guanine nucleotide exchange factor which is related to area like Mutation and eIF2. The study incorporates disciplines such as Secretory protein and Protein disulfide-isomerase in addition to Protein folding. Her research investigates the connection between ISRIB and topics such as G alpha subunit that intersect with problems in Phosphorylation.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

Heather P. Harding;Yuhong Zhang;David Ron.
Nature (1999)

3548 Citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

Heather P Harding;Isabel Novoa;Yuhong Zhang;Huiqing Zeng.
Molecular Cell (2000)

3386 Citations

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

Heather P. Harding;Yuhong Zhang;Huiquing Zeng;Isabel Novoa.
Molecular Cell (2003)

3228 Citations

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

Fumihiko Urano;Xiao Zhong Wang;Anne Bertolotti;Yuhong Zhang.
Science (2000)

3180 Citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

Anne Bertolotti;Yuhong Zhang;Linda M. Hendershot;Linda M. Hendershot;Heather P. Harding.
Nature Cell Biology (2000)

3049 Citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

Marcella Calfon;Huiqing Zeng;Fumihiko Urano;Jeffery H Till.
Nature (2002)

2965 Citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

Heather P Harding;Yuhong Zhang;Anne Bertolotti;Huiqing Zeng.
Molecular Cell (2000)

2216 Citations

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

Stefan J. Marciniak;Chi Y. Yun;Seiichi Oyadomari;Isabel Novoa.
Genes & Development (2004)

1953 Citations

Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

J. Nangalia;C.E. Massie;E.J. Baxter;F.L. Nice.
The New England Journal of Medicine (2013)

1883 Citations

A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

Michael Boyce;Kevin F. Bryant;Céline Jousse;Kai Long.
Science (2005)

1535 Citations

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