World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
25511
World Ranking
7638
National Ranking
3475

Research.com Recognitions

  • 2017 - AAI-BD Biosciences Investigator Award, American Association of Immunologists

Overview

Jonathan C. Kagan is affiliated with Boston Children's Hospital in the United States. Their research primarily focuses on immunology and microbiology, with significant work in the subfields of immunology, molecular biology, epidemiology, physiology, and oncology. The main topics explored include inflammasome and immune disorders, interferon and immune responses, immune response and inflammation, immune cell function and interaction, heme oxygenase-1 and carbon monoxide, immunotherapy and immune responses, and influenza virus research studies.

Jonathan C. Kagan has contributed to numerous publications, with frequent appearances in key scientific venues such as bioRxiv (Cold Spring Harbor Laboratory), Immunity, Science Immunology, Cell, and Nature. Their scholarly output includes the following recent papers:

  • Toll-like Receptors and the Control of Immunity, 2020, Cell
  • Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway, 2021, Cell
  • Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis, 2023, Immunity
  • HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation, 2020, Science
  • Molecular mechanisms of gasdermin D pore-forming activity, 2023, Nature Immunology

The collaborative nature of their work is reflected in frequent co-authorship with several researchers, including Pascal Devant, Charles L. Evavold, Hao Wu, Dania Zhivaki, and Iva Hafner-Bratkovič.

Jonathan C. Kagan's publication record highlights a consistent contribution to advancing understanding within immunology and related molecular mechanisms. They have received the AAI-BD Biosciences Investigator Award from the American Association of Immunologists in 2017.

Best Publications

  • Toll-like Receptors and the Control of Immunity.

    Katherine A. Fitzgerald;Jonathan C. Kagan

  • TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta.

    Jonathan C Kagan;Tian Su;Tiffany Horng;Tiffany Horng;Amy Chow;Amy Chow

  • Innate immune pattern recognition: a cell biological perspective.

    Sky W. Brubaker;Kevin S. Bonham;Ivan Zanoni;Jonathan C. Kagan

  • CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

    Ivan Zanoni;Renato Ostuni;Lorri R. Marek;Simona Barresi

  • Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling

    Jonathan C. Kagan;Ruslan Medzhitov

  • The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.

    Charles L. Evavold;Jianbin Ruan;Yunhao Tan;Shiyu Xia

  • Peroxisomes are signaling platforms for antiviral innate immunity

    Evelyn Dixit;Steeve Boulant;Yijing Zhang;Amy S.Y. Lee

  • A cell biological view of Toll-like receptor function: regulation through compartmentalization

    Gregory M. Barton;Jonathan C. Kagan

  • Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA

    Gregory M Barton;Jonathan C Kagan;Ruslan Medzhitov

  • A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes.

    Hiroki Nagai;Jonathan C. Kagan;Xinjun Zhu;Richard A. Kahn

  • Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites

    Jonathan C. Kagan;Craig R. Roy

  • An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

    Ivan Zanoni;Ivan Zanoni;Yunhao Tan;Marco Di Gioia;Achille Broggi

  • Diverse intracellular pathogens activate type III interferon expression from peroxisomes

    Charlotte Odendall;Evelyn Dixit;Fabrizia Stavru;Helene Bierne

  • Legionella Subvert the Functions of Rab1 and Sec22b to Create a Replicative Organelle

    Jonathan C. Kagan;Mary-Pat Stein;Marc Pypaert;Craig R. Roy

  • A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells

    Hiroki Nagai;Eric D. Cambronne;Jonathan C. Kagan;Juan Carlos Amor

  • Early innate immune responses to bacterial LPS.

    Charles V Rosadini;Jonathan C Kagan

  • A Promiscuous Lipid-Binding Protein Diversifies the Subcellular Sites of Toll-like Receptor Signal Transduction

    Kevin S. Bonham;Megan H. Orzalli;Kachiko Hayashi;Amaya I. Wolf

  • Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.

    Charles L. Evavold;Iva Hafner-Bratkovič;Pascal Devant;Jasmin M. D’Andrea;Jasmin M. D’Andrea

  • Guideline for flow cytometric immunophenotyping: a report from the National Institute of Allergy and Infectious Diseases, Division of AIDS.

    Theresa Calvelli;Thomas N. Denny;Helene Paxton;Rebecca Gelman

  • HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

    Venkat Giri Magupalli;Venkat Giri Magupalli;Roberto Negro;Roberto Negro;Yuzi Tian;Yuzi Tian;Arthur V. Hauenstein;Arthur V. Hauenstein

Frequent Co-Authors

Ivan Zanoni
Ivan Zanoni Boston Children's Hospital
Craig R. Roy
Craig R. Roy Yale University
Alan L. Landay
Alan L. Landay The University of Texas Medical Branch at Galveston
Wayne I. Lencer
Wayne I. Lencer Harvard University
Hao Wu
Hao Wu Harvard University
Steeve Boulant
Steeve Boulant University of Florida
Donna Mildvan
Donna Mildvan Icahn School of Medicine at Mount Sinai
Katherine A. Fitzgerald
Katherine A. Fitzgerald University of Massachusetts Chan Medical School
Laurie H. Glimcher
Laurie H. Glimcher Harvard University
Akiko Iwasaki
Akiko Iwasaki Yale University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Jonathan C. Kagan

Trending Scientists

Recently Published Articles