World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
93
Citations
28909
World Ranking
595
National Ranking
274

Research.com Recognitions

  • 2009 - Member of the National Academy of Sciences

Overview

Ralph R. Isberg is affiliated with Tufts University in the United States and has contributed extensively to the field of Biochemistry, Genetics, and Molecular Biology. Their research spans multiple subfields, including Endocrinology, Molecular Biology, Molecular Medicine, Genetics, and Immunology. The scientist's work covers a variety of topics, particularly focused on bacteria and related mechanisms.

Key research topics in their work include:

  • Legionella and Acanthamoeba research
  • Antibiotic Resistance in Bacteria
  • Vibrio bacteria research studies
  • Heme Oxygenase-1 and Carbon Monoxide
  • Bacterial biofilms and quorum sensing
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Yersinia bacterium, plague, ectoparasites research

They have published numerous papers, with several recent notable contributions including:

  • "Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope," 2020, Nature Communications
  • "Essential Gene Analysis in Acinetobacter baumannii by High-Density Transposon Mutagenesis and CRISPR Interference," 2021, Journal of Bacteriology
  • "Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity," 2020, Nature Communications
  • "Immunosuppression broadens evolutionary pathways to drug resistance and treatment failure during Acinetobacter baumannii pneumonia in mice," 2022, Nature Microbiology
  • "Members of the Legionella pneumophila Sde family target tyrosine residues for phosphoribosyl-linked ubiquitination," 2021, RSC Chemical Biology

Frequent collaborators in their research include:

  • Tim van Opijnen
  • Wenwen Huo
  • Edward Geisinger
  • Seongok Kim
  • Sapna Syal

Their work has appeared most frequently in the following publication venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • mBio
  • mSphere

Ralph R. Isberg was recognized as a Member of the National Academy of Sciences in 2009, underscoring their engagement with the scientific community over many years.

Best Publications

  • Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells

    Ralph R. Isberg;John M. Leong

  • The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

    Ralph R. Isberg;Tamara J. O'Connor;Matthew Heidtman

  • Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila

    Karen H. Berger;Ralph R. Isberg

  • Conjugative Transfer by the Virulence System of Legionella pneumophila

    Joseph. P. Vogel;Helene L. Andrews;Swee Kee Wong;Ralph R. Isberg

  • Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells

    Ralph R. Isberg;Deborah L. Voorhis;Stanley Falkow

  • Association of Legionella pneumophila with the macrophage endoplasmic reticulum.

    M S Swanson;R R Isberg

  • A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured animal cells by Escherichia coli K-12.

    Ralph R. Isberg;Stanley Falkow

  • Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system.

    Russell E. Vance;Ralph R. Isberg;Daniel A. Portnoy

  • Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer

    Zhao-Qing Luo;Ralph R. Isberg

  • Antibiotic modulation of capsular exopolysaccharide and virulence in Acinetobacter baumannii.

    Edward Geisinger;Ralph R. Isberg

  • The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation

    Augustine Choy;Julia Dancourt;Brian Mugo;Tamara J. O’Connor

  • Targeting of Host Rab GTPase Function by the Intravacuolar Pathogen Legionella pneumophila

    Matthias P. Machner;Ralph R. Isberg

  • Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake

    Craig R. Roy;Karen H. Berger;Ralph R. Isberg

  • The Interaction of Bacteria with Mammalian Cells

    Stanley Falkow;Ralph R. Isberg;Daniel A. Portnoy

  • Discrimination between intracellular uptake and surface adhesion of bacterial pathogens

    Ralph R. Isberg

  • Crystal Structure of Invasin: A Bacterial Integrin-Binding Protein

    Zsuzsa A. Hamburger;Michele S. Brown;Ralph R. Isberg;Pamela J. Bjorkman

  • Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein.

    J M Leong;R S Fournier;R R Isberg

  • Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene

    Karen H. Berger;Jennifer J. Merriam;Ralph R. Isberg

  • Legionella eukaryotic-like type IV substrates interfere with organelle trafficking.

    Karim Suwwan de Felipe;Robert T. Glover;Xavier Charpentier;O. Roger Anderson

  • The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity

    Gloria M. Conover;Isabelle Derré;Joseph P. Vogel;Ralph R. Isberg

Frequent Co-Authors

Stanley Falkow
Stanley Falkow Stanford University
John M. Leong
John M. Leong Tufts University
Petra Dersch
Petra Dersch University of Münster
Virginia L. Miller
Virginia L. Miller University of North Carolina at Chapel Hill
Michele S. Swanson
Michele S. Swanson University of Michigan–Ann Arbor
Craig R. Roy
Craig R. Roy Yale University
Zhao-Qing Luo
Zhao-Qing Luo Purdue University West Lafayette
Dana Boyd
Dana Boyd Harvard University
Daniel A. Portnoy
Daniel A. Portnoy University of California, Berkeley
William F. Dietrich
William F. Dietrich Novartis (Switzerland)

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