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Microbiology

D-Index
73
Citations
19153
World Ranking
1662
National Ranking
714

Overview

John M. Leong is affiliated with Tufts University in the United States. Their research spans several interconnected fields with a focus on medicine, immunology, microbiology, and molecular biology. The primary areas of study include epidemiology, immunology, infectious diseases, parasitology, and endocrinology.

The scientist's work concentrates on key topics such as pneumonia and respiratory infections, vector-borne infectious diseases, Escherichia coli research, viral gastroenteritis research and epidemiology, bacteriophages and microbial interactions, Pneumocystis jirovecii pneumonia detection and treatment, and gut microbiota and health.

Their recent publications cover significant contributions to host-pathogen interactions and microbial immune defense mechanisms. Selected papers include:

  • "Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut" (2023), published in Cell Host & Microbe
  • "Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging" (2020), published in Proceedings of the National Academy of Sciences
  • "Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria" (2022), published in The Journal of Experimental Medicine
  • "Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C" (2020), published in PLoS Pathogens
  • "Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination" (2023), published in PLoS Pathogens

John M. Leong frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), PLoS Pathogens, Proceedings of the National Academy of Sciences, Journal of Biological Chemistry, and Infection and Immunity.

Frequent collaborators include Shuying Xu, Simin Nikbin Meydani, Marcia S. Osburne, Brandon L. Garcia, and Anishma Shrestha.

Best Publications

  • Experimental Observation of a Heavy Particle $J$

    J. J. Aubert;U. Becker;P. J. Biggs;J. Burger

  • Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells

    Ralph R. Isberg;John M. Leong

  • TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.

    Vijay A.K. Rathinam;Sivapriya Kailasan Vanaja;Sivapriya Kailasan Vanaja;Lisa Waggoner;Anna Sokolovska

  • B1b Lymphocytes Confer T Cell-Independent Long-Lasting Immunity

    Kishore R. Alugupalli;John M. Leong;Robert T. Woodland;Masamichi Muramatsu

  • Siderophores: Their Biochemistry and Possible Role in the Biocontrol of Plant Pathogens

    Unknown

  • Pseudomonas siderophores: A mechanism explaining disease-suppressive soils

    Unknown

  • EspFU Is a Translocated EHEC Effector that Interacts with Tir and N-WASP and Promotes Nck-Independent Actin Assembly

    Kenneth Geno Campellone;Douglas Robbins;John M. Leong

  • Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi.

    R A Kalish;J M Leong;A C Steere

  • Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein.

    J M Leong;R S Fournier;R R Isberg

  • Hierarchical regulation of WASP/WAVE proteins.

    Shae B. Padrick;Hui Chun Cheng;Ayman M. Ismail;Sanjay C. Panchal

  • A tyrosine-phosphorylated 12-amino-acid sequence of enteropathogenic Escherichia coli Tir binds the host adaptor protein Nck and is required for Nck localization to actin pedestals.

    Kenneth Geno Campellone;Andrew Giese;Donald J. Tipper;John M. Leong

  • Integrin alpha IIb beta 3 mediates binding of the Lyme disease agent Borrelia burgdorferi to human platelets

    Jenifer Coburn;John M. Leong;John K. Erban

  • The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes

    Kishore R. Alugupalli;Rachel M. Gerstein;Jianzhu Chen;Eva Szomolanyi-Tsuda

  • Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycans.

    Joshua Richard Fischer;Kimberly T. LeBlanc;John M. Leong

  • The phi 80 and P22 attachment sites. Primary structure and interaction with Escherichia coli integration host factor.

    J M Leong;S Nunes-Düby;C F Lesser;P Youderian

  • Tails of two Tirs: actin pedestal formation by enteropathogenic E. coli and enterohemorrhagic E. coli O157:H7.

    Kenneth Geno Campellone;John M. Leong

  • Identification of a candidate glycosaminoglycan-binding adhesin of the Lyme disease spirochete Borrelia burgdorferi.

    Nikhat Parveen;John M. Leong

  • Role for the outer membrane ferric siderophore receptor PupB in signal transduction across the bacterial cell envelope.

    M Koster;W van Klompenburg;W Bitter;J Leong

  • Characterization of a candidate Borrelia burgdorferi beta3-chain integrin ligand identified using a phage display library.

    Jenifer Coburn;Wambui Chege;Loranne Magoun;Sarah C. Bodary

  • Decorin-binding proteins A and B confer distinct mammalian cell type-specific attachment by Borrelia burgdorferi, the Lyme disease spirochete

    Joshua Richard Fischer;Nikhat Parveen;Loranne Magoun;John M. Leong

  • Humoral immune response to outer surface protein C of Borrelia burgdorferi in Lyme disease: role of the immunoglobulin M response in the serodiagnosis of early infection.

    B P Fung;G L McHugh;J M Leong;A C Steere

  • Integrins αvβ3 and α5β1 mediate attachment of Lyme disease spirochetes to human cells

    Jenifer Coburn;Loranne Magoun;Sarah C. Bodary;John M. Leong

Frequent Co-Authors

Scott B. Snapper
Scott B. Snapper Boston Children's Hospital
Simin Nikbin Meydani
Simin Nikbin Meydani Tufts University
Beth A. McCormick
Beth A. McCormick University of Massachusetts Chan Medical School
Ralph R. Isberg
Ralph R. Isberg Tufts University
Andrew Camilli
Andrew Camilli Tufts University
Peter Weisbeek
Peter Weisbeek Utrecht University
Sau Lan Wu
Sau Lan Wu University of Wisconsin–Madison
Alan D. Michelson
Alan D. Michelson Harvard University
Katherine A. Fitzgerald
Katherine A. Fitzgerald University of Massachusetts Chan Medical School

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