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Nicholas P. Cianciotto

Nicholas P. Cianciotto

D-Index & Metrics

Microbiology

D-Index
61
Citations
10482
World Ranking
3050
National Ranking
1205

Overview

Nicholas P. Cianciotto is affiliated with Northwestern University in the United States. Their research primarily revolves around the fields of Biochemistry, Genetics and Molecular Biology, with a focus on several specific subfields including Endocrinology, Immunology, Molecular Biology, Plant Science, and Epidemiology.

Their scientific work covers a range of main topics, among which the most prominent is Legionella and Acanthamoeba research. Other featured areas include Vibrio bacteria research studies, Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Bacterial biofilms and quorum sensing, Infections and bacterial resistance, Heme Oxygenase-1 and Carbon Monoxide, and Plant Pathogenic Bacteria Studies.

Cianciotto has contributed multiple recent papers that explore bacterial mechanisms, host-pathogen interactions, and secretion systems. Notable publications include:

  • Structure and functional analysis of the Legionella pneumophila chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation, 2020, published in PLoS Pathogens
  • Human macrophages utilize a wide range of pathogen recognition receptors to recognize Legionella pneumophila, including Toll-Like Receptor 4 engaging Legionella lipopolysaccharide and the Toll-like Receptor 3 nucleic-acid sensor, 2021, published in PLoS Pathogens
  • Effectors of the Stenotrophomonas maltophilia Type IV Secretion System Mediate Killing of Clinical Isolates of Pseudomonas aeruginosa, 2021, published in mBio
  • Structure, Dynamics and Cellular Insight Into Novel Substrates of the Legionella pneumophila Type II Secretion System, 2020, published in Frontiers in Molecular Biosciences
  • Legionella pneumophila Cas2 Promotes the Expression of Small Heat Shock Protein C2 That Is Required for Thermal Tolerance and Optimal Intracellular Infection, 2022, published in Infection and Immunity

Frequent collaborators in their research work include James A. Garnett, Saima Rehman, Richard C. White, Lubov Grigoryeva, and Katherine H. Richardson. These coauthors have contributed to multiple publications alongside Cianciotto, indicating ongoing collaborative efforts in relevant fields.

Their work has been published in a variety of venues, with the most frequent being:

  • mBio
  • Infection and Immunity
  • PLoS Pathogens
  • Microbiology Resource Announcements
  • Nature Communications

Best Publications

  • Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA.

    Doreen E. Gillespie;Sean F. Brady;Alan D. Bettermann;Nicholas P. Cianciotto

  • Type II secretion: a protein secretion system for all seasons

    Nicholas P. Cianciotto

  • Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages.

    Nicholas P. Cianciotto;Barry S. Fields

  • A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection.

    N P Cianciotto;B I Eisenstein;C H Mody;G B Toews

  • DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity.

    N C Engleberg;C Carter;D R Weber;N P Cianciotto

  • Legionella pneumophila type II secretome reveals unique exoproteins and a chitinase that promotes bacterial persistence in the lung

    Sruti DebRoy;Jenny Dao;Maria Söderberg;Ombeline Rossier

  • Legionella pneumophila feoAB Promotes Ferrous Iron Uptake and Intracellular Infection

    Marianne Robey;Nicholas P. Cianciotto

  • A Mutation in the mip Gene Results in an Attenuation of Legionella pneumophila Virulence

    N P Cianciotto;B I Eisenstein;C H Mody;N C Engleberg

  • Expanding Role of Type II Secretion in Bacterial Pathogenesis and Beyond.

    Nicholas P. Cianciotto;Richard C. White

  • Legionella pneumophila Type II Protein Secretion Promotes Virulence in the A/J Mouse Model of Legionnaires' Disease Pneumonia

    Ombeline Rossier;Shawn R. Starkenburg;Nicholas P. Cianciotto

  • Pathogenicity of Legionella pneumophila

    Nicholas P. Cianciotto

  • The Dot/Icm Type IV Secretion System of Legionella pneumophila Is Essential for the Induction of Apoptosis in Human Macrophages

    Steven D. Zink;Lisa Pedersen;Nicholas P. Cianciotto;Yousef Abu Kwaik

  • The prepilin peptidase is required for protein secretion by and the virulence of the intracellular pathogen Legionella pneumophila.

    Mark R. Liles;Paul H. Edelstein;Nicholas P. Cianciotto

  • The Secreted Pyomelanin Pigment of Legionella pneumophila Confers Ferric Reductase Activity

    Christa H. Chatfield;Nicholas P. Cianciotto

  • Type II protein secretion is a subset of the pilD-dependent processes that facilitate intracellular infection by Legionella pneumophila

    Ombeline Rossier;Nicholas P. Cianciotto

  • Identification of Legionella pneumophila rcp, a pagP-like gene that confers resistance to cationic antimicrobial peptides and promotes intracellular infection

    Marianne Robey;William O'Connell;Nicholas P. Cianciotto

  • Identification and Temperature Regulation of Legionella pneumophila Genes Involved in Type IV Pilus Biogenesis and Type II Protein Secretion

    Mark R. Liles;V. K. Viswanathan;Nicholas P. Cianciotto

  • Characterization of the Gene Encoding the Major Secreted Lysophospholipase A of Legionella pneumophila and Its Role in Detoxification of Lysophosphatidylcholine

    Antje Flieger;Birgid Neumeister;Nicholas P. Cianciotto

  • Secreted enzymatic activities of wild-type and pilD-deficient Legionella pneumophila.

    Virginia Aragon;Sherry Kurtz;Antje Flieger;Birgid Neumeister

  • The CRISPR-Associated Gene cas2 of Legionella pneumophila Is Required for Intracellular Infection of Amoebae

    Felizza F. Gunderson;Nicholas P. Cianciotto

Frequent Co-Authors

Grant J. Jensen
Grant J. Jensen California Institute of Technology
Mark R. Liles
Mark R. Liles Auburn University
Elizabeth L. Hartland
Elizabeth L. Hartland Hudson Institute of Medical Research
Paul H. Edelstein
Paul H. Edelstein University of Pennsylvania
Brendan Mulhern
Brendan Mulhern University of Technology Sydney
Carmen Buchrieser
Carmen Buchrieser Institut Pasteur
Alastair G. McEwan
Alastair G. McEwan University of Queensland
Pierre Cornelis
Pierre Cornelis Vrije Universiteit Brussel
Ralph R. Isberg
Ralph R. Isberg Tufts University
Michael P. Jennings
Michael P. Jennings Griffith University

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