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Microbiology

D-Index
78
Citations
18649
World Ranking
1313
National Ranking
580

Overview

Craig R. Roy is affiliated with Yale University in the United States and has focused research efforts primarily in the fields of Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology, and Medicine. Their published work spans a wide range of studies related to infectious diseases, molecular mechanisms, and cellular biology.

The scientist has contributed to key topics including:

  • Legionella and Acanthamoeba research
  • Vector-borne infectious diseases
  • Vibrio bacteria research studies
  • Escherichia coli research studies
  • Toxoplasma gondii Research Studies
  • Mosquito-borne diseases and control
  • Autophagy in Disease and Therapy

Frequent co-authors collaborating with Craig R. Roy include:

  • David Chetrit (10 collaborations)
  • Donghyun Park (7 collaborations)
  • Jun Liu (7 collaborations)
  • Samuel Steiner (7 collaborations)
  • Amit Meir (6 collaborations)

Their research has been published in multiple venues with repeated contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Infection and Immunity
  • Proceedings of the National Academy of Sciences
  • mBio
  • Cellular Microbiology

Notable recent publications include:

  • "Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila" (2020, Nature Communications)
  • "Analysis of Dot/Icm Type IVB Secretion System Subassemblies by Cryoelectron Tomography Reveals Conformational Changes Induced by DotB Binding" (2020, mBio)
  • "Lysosomal degradation products induce Coxiella burnetii virulence" (2020, Proceedings of the National Academy of Sciences)
  • "Legionella pneumophila Excludes Autophagy Adaptors from the Ubiquitin-Labeled Vacuole in Which It Resides" (2020, Infection and Immunity)
  • "Developmental Transitions Coordinate Assembly of the Coxiella burnetii Dot/Icm Type IV Secretion System" (2022, Infection and Immunity)

The subfields they have engaged with encompass areas such as Endocrinology, Parasitology, Epidemiology, Molecular Biology, and Public Health, Environmental and Occupational Health, reflecting a broad interdisciplinary approach to biomedical research.

Best Publications

  • A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes.

    Hiroki Nagai;Jonathan C. Kagan;Xinjun Zhu;Richard A. Kahn

  • Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity.

    Tao Ren;Dario S Zamboni;Craig R Roy;William F Dietrich

  • The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.

    Dario S Zamboni;Koichi S Kobayashi;Koichi S Kobayashi;Tiana Kohlsdorf;Yasunori Ogura

  • Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites

    Jonathan C. Kagan;Craig R. Roy

  • Modulation of host cell function by Legionella pneumophila type IV effectors.

    Andree Hubber;Craig R. Roy

  • The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation

    Augustine Choy;Julia Dancourt;Brian Mugo;Tamara J. O’Connor

  • Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors.

    Xiaoxiao Pan;Anja Lührmann;Ayano Satoh;Michelle A. Laskowski-Arce

  • Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake

    Craig R. Roy;Karen H. Berger;Ralph R. Isberg

  • The road less traveled: transport of Legionella to the endoplasmic reticulum

    Craig R. Roy;Lewis G. Tilney

  • How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane.

    Lewis G. Tilney;Omar S. Harb;Patricia S. Connelly;Camenzind G. Robinson

  • The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor.

    Takahiro Murata;Anna Delprato;Alyssa Ingmundson;Derek K Toomre

  • Legionella pneumophila proteins that regulate Rab1 membrane cycling

    Alyssa Ingmundson;Anna Delprato;David G. Lambright;Craig R. Roy

  • Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins.

    Beatrice Arico;Jeff F. Miller;Craig Roy;Scott Stibitz

  • Modulation of Rab GTPase function by a protein phosphocholine transferase

    Shaeri Mukherjee;Xiaoyun Liu;Kohei Arasaki;Justin A McDonough

  • Legionella Subvert the Functions of Rab1 and Sec22b to Create a Replicative Organelle

    Jonathan C. Kagan;Mary-Pat Stein;Marc Pypaert;Craig R. Roy

  • A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells

    Hiroki Nagai;Eric D. Cambronne;Jonathan C. Kagan;Juan Carlos Amor

  • Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

    Christopher L. Case;Lara J. Kohler;Jonilson B. Lima;Till Strowig

  • The Coxiella burnetii Dot/Icm System Delivers a Unique Repertoire of Type IV Effectors into Host Cells and Is Required for Intracellular Replication

    Kimberly L. Carey;Hayley J. Newton;Anja Lührmann;Anja Lührmann;Craig R. Roy

  • Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth.

    Jörn Coers;Catherine Monahan;Craig R. Roy

  • Pathogen subversion of cell-intrinsic innate immunity.

    Craig R Roy;Edward S Mocarski

Frequent Co-Authors

Dario S. Zamboni
Dario S. Zamboni Universidade de São Paulo
Jacqueline Cherfils
Jacqueline Cherfils École Normale Supérieure Paris-Saclay
Jonathan C. Kagan
Jonathan C. Kagan Boston Children's Hospital
Richard A. Flavell
Richard A. Flavell Yale University
Richard A. Kahn
Richard A. Kahn Emory University
David G. Lambright
David G. Lambright University of Massachusetts Chan Medical School
Ralph R. Isberg
Ralph R. Isberg Tufts University
Gabriel Waksman
Gabriel Waksman University College London
Koichi Kobayashi
Koichi Kobayashi Osaka Metropolitan University
Jun Liu
Jun Liu Yale University

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