World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
11440
World Ranking
17908
National Ranking
797

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Jacqueline Cherfils is affiliated with the École Normale Supérieure Paris-Saclay in France. Their research primarily spans the field of Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology, Cell Biology, Materials Chemistry, Physiology, and Genetics.

The scientist's work covers several main topics including:

  • Cellular transport and secretion
  • Protein Kinase Regulation and GTPase Signaling
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Protein Structure and Dynamics
  • Calcium signaling and nucleotide metabolism
  • Receptor Mechanisms and Signaling

Frequent publication venues for Jacqueline Cherfils include:

  • Biophysical Journal
  • The Cambridge Structural Database
  • FEBS Letters
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Allergy and Clinical Immunology

The scientist has contributed to a range of papers, notable examples include:

  • A toxic palmitoylation of Cdc42 enhances NF-κB signaling and drives a severe autoinflammatory syndrome, 2020, Journal of Allergy and Clinical Immunology
  • Membranes prime the RapGEF EPAC1 to transduce cAMP signaling, 2023, Nature Communications
  • Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation, 2020, Journal of Medicinal Chemistry
  • Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex, 2021, International Journal of Molecular Sciences
  • Molecular principles of bidirectional signalling between membranes and small GTPases, 2023, FEBS Letters

Collaborations form an important part of the scientist's work. Frequent co-authors include:

  • Scott A. McCallum
  • Catherine A. Royer
  • Noam Hantman
  • Richard E. Gillilan
  • François Peurois

Jacqueline Cherfils has been recognized as a Member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Regulation of Small GTPases by GEFs, GAPs, and GDIs

    Jacqueline Cherfils;Mahel Zeghouf

  • Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

    Dominico Vigil;Jacqueline Cherfils;Kent L. Rossman;Channing J. Der

  • Brefeldin A Acts to Stabilize an Abortive ARF-GDP-Sec7 Domain Protein Complex: Involvement of Specific Residues of the Sec7 Domain

    Anne Peyroche;Bruno Antonny;Sylviane Robineau;Joel Acker

  • GEFs: structural basis for their activation of small GTP-binding proteins

    Jacqueline Cherfils;Pierre Chardin

  • Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front–back' communication

    Sebastiano Pasqualato;Louis Renault;Jacqueline Cherfils

  • Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

    Louis Renault;Bernard Guibert;Jacqueline Cherfils

  • Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins.

    Richard A. Kahn;Jacqueline Cherfils;Marek Elias;Ruth C. Lovering

  • Inhibitory signalling to the Arp2/3 complex steers cell migration

    Irene Dang;Roman Gorelik;Carla Sousa-Blin;Emmanuel Derivery

  • Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

    Anna Y. Lee;Robert P. St.Onge;Michael J. Proctor;Iain M. Wallace

  • A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1.

    Sophie Béraud‐Dufour;Sylviane Robineau;Pierre Chardin;Sonia Paris

  • Structure of the Sec7 domain of the Arf exchange factor ARNO

    Jacqueline Cherfils;Julie Ménétrey;Magali Mathieu;Gérard Le Bras

  • Protein-protein recognition analyzed by docking simulation.

    Jacqueline Cherfils;Stéphane Duquerroy;Joël Janin

  • Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery

    Yves Pommier;Jacqueline Cherfils

  • Molecular docking programs successfully predict the binding of a beta-lactamase inhibitory protein to TEM-1 beta-lactamase.

    N.C.J. Strynadka;M. Eisenstein;E. Katchalski-Katzir;B.K. Shoichet

  • Redox signalling in the chloroplast: structure of oxidized pea fructose‐1,6‐bisphosphate phosphatase

    Mohammed Chiadmi;Mohammed Chiadmi;Alda Navaza;Myroslawa Miginiac‐Maslow;Jean‐Pierre Jacquot

  • Three-dimensional structure of nucleoside diphosphate kinase.

    Joël Janin;Christian Dumas;Solange Moréra;Yingwu Xu

  • The structural GDP/GTP cycle of human Arf6

    Sebastiano Pasqualato;Julie Ménétrey;Michel Franco;Jacqueline Cherfils

  • RhoGDIs Revisited: Novel Roles in Rho Regulation

    Estelle Dransart;Birgitta Olofsson;Jacqueline Cherfils

  • ARF GTPases and their GEFs and GAPs: concepts and challenges

    Elizabeth Sztul;Pei Wen Chen;James E. Casanova;Jacqueline Cherfils

  • Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

    A. Y. Lee;R. P. St.Onge;M. J. Proctor;I. M. Wallace

Frequent Co-Authors

Bruno Antonny
Bruno Antonny Centre national de la recherche scientifique, CNRS
Craig R. Roy
Craig R. Roy Yale University
Pierre Chardin
Pierre Chardin Centre national de la recherche scientifique, CNRS
Corey Nislow
Corey Nislow University of British Columbia
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Guri Giaever
Guri Giaever University of British Columbia
Carmen Buchrieser
Carmen Buchrieser Institut Pasteur
Georges Bismuth
Georges Bismuth Université Paris Cité
Grant W. Brown
Grant W. Brown University of Toronto
Marc Boutry
Marc Boutry Université Catholique de Louvain

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