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Neuroscience

D-Index
54
Citations
9867
World Ranking
4941
National Ranking
2217

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Paula Grammas is affiliated with the University of Rhode Island in the United States. Their research primarily focuses on the intersections of medicine and neuroscience, with an emphasis on physiology, neurology, hematology, cardiology, cardiovascular medicine, and molecular biology.

The main topics covered in Grammas's work include:

  • Alzheimer's disease research and treatments
  • Blood coagulation and thrombosis mechanisms
  • Neuroinflammation and neurodegeneration mechanisms
  • Coagulation, bradykinin, polyphosphates, and angioedema
  • Renin-angiotensin system studies
  • Cholesterol and lipid metabolism
  • Acute ischemic stroke management

Frequent co-authors in their publications include:

  • Jaclyn Iannucci
  • Abhik Sen
  • Shelby L. Johnson
  • Navindra P. Seeram
  • Haripriya Vittal Rao

Grammas has contributed research to several publication venues, including:

  • Frontiers in Neuroscience
  • Current Issues in Molecular Biology
  • Cells
  • Plant Foods for Human Nutrition
  • International Journal of Molecular Sciences

Selected papers authored or co-authored by Grammas include:

  • "Thrombin, a Mediator of Coagulation, Inflammation, and Neurotoxicity at the Neurovascular Interface: Implications for Alzheimer's Disease" (2020), Frontiers in Neuroscience
  • "Isoform-Specific Effects of Apolipoprotein E on Markers of Inflammation and Toxicity in Brain Glia and Neuronal Cells In Vitro" (2021), Current Issues in Molecular Biology
  • "Equol, a Blood-Brain Barrier Permeable Gut Microbial Metabolite of Dietary Isoflavone Daidzein, Exhibits Neuroprotective Effects against Neurotoxins Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells and Caenorhabditis elegans" (2020), Plant Foods for Human Nutrition
  • "Thrombin, a Key Driver of Pathological Inflammation in the Brain" (2023), Cells
  • "Sex Differences in Metabolic Indices and Chronic Neuroinflammation in Response to Prolonged High-Fat Diet in ApoE4 Knock-In Mice" (2022), International Journal of Molecular Sciences

Grammas's research output demonstrates a consistent focus on mechanisms linking coagulation, neuroinflammation, and neurodegenerative diseases such as Alzheimer's disease.

In 2017, they were recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Strategies to advance translational research into brain barriers

    Edward Neuwelt;N Joan Abbott;Lauren Abrey;William A Banks

  • Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease.

    Paula Grammas

  • Inflammatory factors are elevated in brain microvessels in Alzheimer’s disease

    Paula Grammas;Roma Ovase

  • Nitric Oxide Synthase Activity Is Elevated in Brain Microvessels in Alzheimer′s Disease

    M.A. Dorheim;W.R. Tracey;J.S. Pollock;P. Grammas

  • Message and protein-level elevation of tumor necrosis factor α (TNFα) and TNFα-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis

    Kenneth Hensley;Joe Fedynyshyn;Scott Ferrell;Robert A Floyd;Robert A Floyd

  • Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic.

    Sid E. O'Bryant;Michelle M. Mielke;Robert A. Rissman;Simone Lista;Simone Lista

  • Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research

    Sid E. O'Bryant;Veer Gupta;Kim Henriksen;Melissa Edwards

  • Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: Implications for disease pathogenesis

    Paula Grammas;Pezhman Ghatreh Samany;Lakshmi Thirumangalakudi

  • Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases.

    Paula Grammas;Joseph Martinez;Bradley Miller

  • HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: implications for the pathogenesis of HIV-associated dementia.

    Georgette D. Kanmogne;Charles Primeaux;Paula Grammas

  • RANTES upregulation in the Alzheimer's disease brain: A possible neuroprotective role

    Debjani Tripathy;Lakshmi Thirumangalakudi;Paula Grammas

  • Cerebrovascular Transforming Growth Factor-β Contributes to Inflammation in the Alzheimer’s Disease Brain

    Paula Grammas;Roma Ovase

  • The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain.

    Kelly S. Williamson;S. Prasad Gabbita;Shenyun Mou;Melinda West

  • The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice.

    Melinda West;Molina Mhatre;Alex Ceballos;Robert A. Floyd

  • Angiogenic proteins are expressed by brain blood vessels in Alzheimer's disease.

    Lakshmi Thirumangalakudi;Pezhman Ghatreh Samany;Akinkunle Owoso;Brandt Wiskar

  • Thrombin, a mediator of neurotoxicity and memory impairment

    Molina Mhatre;Albert Nguyen;Shabnam Kashani;Tracy Pham

  • Brain Endothelial Cells Synthesize Neurotoxic Thrombin in Alzheimer’s Disease

    Xiangling Yin;Jill Wright;Trevor Wall;Paula Grammas

  • Mechanisms of cell death in primary cortical neurons and PC12 cells.

    Ulrich Reimann-Philipp;Roma Ovase;Paul H. Weigel;Paula Grammas

  • Microvessels from Alzheimer’s Disease Brains Kill Neurons in Vitro

    Paula Grammas;Pete Moore;Paul H. Weigel

  • Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stress.

    Debjani Tripathy;Paula Grammas

  • A damaged microcirculation contributes to neuronal cell death in Alzheimer’s disease☆

    Paula Grammas

  • Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia

    Debjani Tripathy;Alma Sanchez;Xiangling Yin;Jinhua Luo

Frequent Co-Authors

Monique M.B. Breteler
Monique M.B. Breteler German Center for Neurodegenerative Diseases
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Edward G. Stopa
Edward G. Stopa Brown University
Christoph Laske
Christoph Laske University of Tübingen
Kaj Blennow
Kaj Blennow University of Gothenburg
Tatiana Foroud
Tatiana Foroud Indiana University
Alice H. Lichtenstein
Alice H. Lichtenstein Tufts University
Conrad E. Johanson
Conrad E. Johanson Brown University
Henrik Zetterberg
Henrik Zetterberg University of Gothenburg
C. Munro Cullum
C. Munro Cullum The University of Texas Southwestern Medical Center

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