Grant W. Brown mainly investigates Genetics, Gene, Synthetic genetic array, Cell biology and Mutation. His work in Saccharomyces cerevisiae and Gene regulatory network are all subfields of Gene research. His research investigates the connection between Synthetic genetic array and topics such as Gene interaction that intersect with issues in Cullin, Phenotype, Genomics, Functional genomics and Ubiquitin ligase complex.
His Cell biology study integrates concerns from other disciplines, such as Eukaryotic DNA replication, DNA replication factor CDT1, Origin recognition complex, Control of chromosome duplication and DNA repair. His DNA repair research focuses on subjects like Immunoprecipitation, which are linked to DNA damage. He has researched Mutation in several fields, including Base excision repair, Establishment of sister chromatid cohesion, Chromatid, Fungal protein and Replication fork protection complex.
Grant W. Brown mainly focuses on Genetics, Cell biology, DNA replication, Gene and DNA damage. Genetics is a component of his Mutation, Synthetic genetic array, Genome, Functional genomics and Genomics studies. His Synthetic genetic array study combines topics in areas such as Gene interaction and Allele.
His Cell biology research includes elements of DNA re-replication, Eukaryotic DNA replication, CHEK1, DNA and Molecular biology. His work in Gene addresses issues such as Genome instability, which are connected to fields such as Homologous recombination and Helicase. His DNA damage study combines topics from a wide range of disciplines, such as Schizosaccharomyces pombe, Cancer research and DNA repair.
The scientist’s investigation covers issues in Cell biology, DNA replication, Gene, Saccharomyces cerevisiae and Genome instability. His research in Cell biology intersects with topics in Ubiquitin, Ribosome and DNA, Endonuclease. His DNA replication research is multidisciplinary, incorporating perspectives in Sonic hedgehog, Cancer, Postreplication repair and Replication stress.
To a larger extent, Grant W. Brown studies Genetics with the aim of understanding Gene. The study incorporates disciplines such as Amino acid, Serine, Ploidy, Spindle pole body and Eukaryote in addition to Saccharomyces cerevisiae. The various areas that Grant W. Brown examines in his Genome instability study include Homologous recombination, Genome, Direct repeat, DNA mismatch repair and Computational biology.
His primary areas of study are Cell biology, DNA, DNA damage, Gene and DNA replication. His study in Cell biology is interdisciplinary in nature, drawing from both Ribosome profiling, Ubiquitin and Messenger RNA. His work on Topoisomerase as part of general DNA study is frequently linked to RNA polymerase II and Cellular homeostasis, bridging the gap between disciplines.
His Gene study improves the overall literature in Genetics. In general Genetics, his work in Shu complex, Mutant and Methyl methanesulfonate is often linked to Zeocin linking many areas of study. His DNA replication research incorporates elements of Histone, Computational biology, Genome instability and Proliferating cell nuclear antigen.
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Global Mapping of the Yeast Genetic Interaction Network
Amy Hin Yan Tong;Guillaume Lesage;Gary D. Bader;Huiming Ding.
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
Sean R. Collins;Kyle M. Miller;Nancy L. Maas;Assen Roguev.
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
Ainslie B Parsons;Renée L Brost;Huiming Ding;Zhijian Li.
Nature Biotechnology (2004)
Regulation of Chromosome Replication
Thomas J. Kelly;Grant W. Brown.
Annual Review of Biochemistry (2000)
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress
Johnny M. Tkach;Askar Yimit;Anna Y. Lee;Michael Riffle.
Nature Cell Biology (2012)
Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase.
Shigeki Nagai;Karine Dubrana;Monika Tsai-Pflugfelder;Marta B. Davidson.
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale
Anastasia Baryshnikova;Michael Costanzo;Yungil Kim;Huiming Ding.
Nature Methods (2010)
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.
Michael Chang;Mohammed Bellaoui;Charles Boone;Grant W. Brown.
Proceedings of the National Academy of Sciences of the United States of America (2002)
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
Hong Xu;Marco Di Antonio;Steven McKinney;Veena Mathew.
Nature Communications (2017)
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates
Leonard Wu;Csanad Z. Bachrati;Jiongwen Ou;Chang Xu.
Proceedings of the National Academy of Sciences of the United States of America (2006)
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