World's Best Scientists 2026 revealed!
Grant W. Brown

Grant W. Brown

D-Index & Metrics

Genetics

D-Index
57
Citations
16179
World Ranking
3379
National Ranking
131

Overview

Grant W. Brown is affiliated with the University of Toronto in Canada. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with 114 publications contributing to this domain.

Their subfields of study include Molecular Biology, Genetics, Cell Biology, Cancer Research, and Oncology. The main topics covered in their work encompass DNA Repair Mechanisms, RNA modifications and cancer, RNA and protein synthesis mechanisms, Fungal and yeast genetics research, RNA Research and Splicing, Genomics and Chromatin Dynamics, and Microtubule and mitosis dynamics.

Grant W. Brown has contributed to multiple recent papers, including:

  • A Genetic Map of the Response to DNA Damage in Human Cells, 2020, Cell
  • RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors, 2021, Journal of Clinical Investigation
  • Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation, 2022, eLife
  • Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma, 2020, Nature Cancer
  • RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells, 2023, Nucleic Acids Research

The scientist frequently publishes in several venues, with a notable number of publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • G3 Genes Genomes Genetics
  • Nature Cancer
  • Genetics

Frequent co-authors collaborating with Grant W. Brown include:

  • Raphaël Loll-Krippleber
  • Brandon Ho
  • Matthew D. Berg
  • Yanrui Zhu
  • Christopher J. Brandl

Best Publications

  • Global Mapping of the Yeast Genetic Interaction Network

    Amy Hin Yan Tong;Guillaume Lesage;Gary D. Bader;Huiming Ding

  • Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

    Sean R. Collins;Kyle M. Miller;Nancy L. Maas;Assen Roguev

  • Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

    Ainslie B Parsons;Renée L Brost;Huiming Ding;Zhijian Li

  • Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

    Johnny M. Tkach;Askar Yimit;Anna Y. Lee;Michael Riffle

  • Regulation of Chromosome Replication

    Thomas J. Kelly;Grant W. Brown

  • Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase.

    Shigeki Nagai;Karine Dubrana;Monika Tsai-Pflugfelder;Marta B. Davidson

  • CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

    Hong Xu;Marco Di Antonio;Steven McKinney;Veena Mathew

  • Unification of Protein Abundance Datasets Yields a Quantitative Saccharomyces cerevisiae Proteome

    Brandon Ho;Anastasia Baryshnikova;Grant W. Brown

  • A Genetic Map of the Response to DNA Damage in Human Cells

    Michele Olivieri;Michele Olivieri;Tiffany Cho;Tiffany Cho;Alejandro Álvarez-Quilón;Kejiao Li

  • Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

    Anastasia Baryshnikova;Michael Costanzo;Yungil Kim;Huiming Ding

  • A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.

    Michael Chang;Mohammed Bellaoui;Charles Boone;Grant W. Brown

  • BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates

    Leonard Wu;Csanad Z. Bachrati;Jiongwen Ou;Chang Xu

  • Identification of Protein Complexes Required for Efficient Sister Chromatid Cohesion

    Melanie L. Mayer;Isabelle Pot;Michael Chang;Hong Xu

  • The synthetic genetic interaction spectrum of essential genes.

    Armaity P Davierwala;Jennifer Haynes;Zhijian Li;Renée L Brost

  • Systematic analysis of complex genetic interactions

    Elena Kuzmin;Benjamin VanderSluis;Wen Wang;Guihong Tan

  • Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

    Anna Y. Lee;Robert P. St.Onge;Michael J. Proctor;Iain M. Wallace

  • Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

    Prasad V. Jallepalli;Grant W. Brown;Marco Muzi-Falconi;Deborah Tien

  • RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.

    Dongyi Xu;Rong Guo;Alexandra Sobeck;Csanad Z. Bachrati

  • Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

    A. Y. Lee;R. P. St.Onge;M. J. Proctor;I. M. Wallace

  • Data from: Systematic analysis of complex genetic interactions

    Elena Kuzmin;Benjamin VanderSluis;Wen Wang;Guihong Tan

Frequent Co-Authors

Charles Boone
Charles Boone University of Toronto
Daniel Durocher
Daniel Durocher Lunenfeld-Tanenbaum Research Institute
Brenda J. Andrews
Brenda J. Andrews University of Toronto
Michael Costanzo
Michael Costanzo University of Toronto
Corey Nislow
Corey Nislow University of British Columbia
Guri Giaever
Guri Giaever University of British Columbia
Chad L. Myers
Chad L. Myers University of Minnesota
Zhaolei Zhang
Zhaolei Zhang University of Toronto
Ian D. Hickson
Ian D. Hickson University of Copenhagen
Frederick P. Roth
Frederick P. Roth Lunenfeld-Tanenbaum Research Institute

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

A background in genetics can open doors to multiple healthcare careers—many of which can be pursued through online study. For those interested in nursing, there are options to attend a nursing school without teas test requirements, making the application process more accessible.

If you’re seeking managerial roles within healthcare, the cost of a master's program can be a concern. Exploring the mha degree cost can help you find budget-friendly pathways to advance your career in healthcare administration.

For those aiming to enter the field quickly, accelerated options like a lpn fast track program allow you to begin working and gaining experience sooner, which can be especially appealing for career-changers or those looking to upskill.

Higher-level research and teaching positions may require advanced credentials like a doctorate. Consider the online phd nursing programs for a flexible path to reaching these goals.

Best Scientists Citing Grant W. Brown

Trending Scientists

Recently Published Articles